Gene Symbol | Tppp |
Entrez Gene ID | 361466 |
Full Name | tubulin polymerization promoting protein |
Synonyms | RGD1310121 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Tppp cDNA ORF clone
Gene Symbol | Tppp |
Entrez Gene ID | 361466 |
Full Name | tubulin polymerization promoting protein |
Synonyms | RGD1310121 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006227793.2 | XP_006227855.1 | tubulin polymerization-promoting protein isoform X1 |
NM_001108461.1 | NP_001101931.1 | tubulin polymerization-promoting protein |
XM_006227794.2 | XP_006227856.1 | tubulin polymerization-promoting protein isoform X1 |
Rattus norvegicus (Norway rat) | Tppp | NP_001101931.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP006948 | XP_308808.4 |
TPPP | XP_001095130.1 | |
Bos taurus (cattle) | TPPP | NP_776401.1 |
Mus musculus (house mouse) | Tppp | NP_878259.1 |
Gallus gallus (chicken) | TPPP | XP_418894.1 |
Drosophila melanogaster (fruit fly) | CG4893 | NP_001261939.1 |
Pan troglodytes (chimpanzee) | TPPP | XP_003310658.1 |
Canis lupus familiaris (dog) | TPPP | XP_545196.3 |
Homo sapiens (human) | TPPP | NP_008961.1 |
Tubulin polymerization-promoting protein (TPPP/p25?) promotes unconventional secretion of ?-synuclein through exophagy by impairing autophagosome-lysosome fusion.
Ejlerskov P, Rasmussen I, Nielsen TT, Bergstr?m AL, Tohyama Y, Jensen PH, Vilhardt F
The Journal of biological chemistry288(24)17313-35(2013 Jun)
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.
Ol?h J, Vincze O, Vir?k D, Simon D, Bozs? Z, T?k?si N, Horv?th I, Hlavanda E, Kov?cs J, Magyar A, Sz?cs M, Orosz F, Penke B, Ov?di J
The Journal of biological chemistry286(39)34088-100(2011 Sep)
Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation.
Lehotzky A, Lau P, Tok?si N, Muja N, Hudson LD, Ov?di J
Glia58(2)157-68(2010 Jan)
The expression of tubulin polymerization promoting protein TPPP/p25alpha is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress.
Goldbaum O, Jensen PH, Richter-Landsberg C
Glia56(16)1736-46(2008 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Exophagy, with or without expression of TPPP, may be an important physiological mechanism for unconventional secretion of alpha-synuclein from dopaminergic neurons.
Title: Tubulin polymerization-promoting protein (TPPP/p25?) promotes unconventional secretion of ?-synuclein through exophagy by impairing autophagosome-lysosome fusion.
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.
Title: Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.
These results support an essential role for TPPP/p25 in oligodendrocyte differentiation likely via rearrangement of the microtubule system during the process elongation prior to the onset of myelination.
Title: Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation.
Malfunction of the proteasomal system, leading to the accumulation of aggregation prone proteins and the pro-aggregatory protein TPPP/p25alpha, is causally related to the protein aggregation process in a variety of neurodegenerative diseases.
Title: The expression of tubulin polymerization promoting protein TPPP/p25alpha is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress.
The following Tppp gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tppp cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa07376 | |
Clone ID Related Accession (Same CDS sequence) | XM_006227793.2 , NM_001108461.1 , XM_006227794.2 | |
Accession Version | NM_001108461.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-16 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | tubulin polymerization-promoting protein | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474002.2. On or before Oct 4, 2007 this sequence version replaced XM_341746.3, XM_001060230.1. ##Evidence-Data-START## Transcript exon combination :: CK600925.1, CK357749.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCTGACA GCAAGGCCAA GCCCACCAAA GCTGCCAACA AGACACCACC CAAGTCCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001101931.1 |
CDS | 81..737 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001108461.1 |
1 | ATGGCTGACA GCAAGGCCAA GCCCACCAAA GCTGCCAACA AGACACCACC CAAGTCCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa07376 | |
Clone ID Related Accession (Same CDS sequence) | XM_006227793.2 , NM_001108461.1 , XM_006227794.2 | |
Accession Version | XM_006227793.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | tubulin polymerization-promoting protein isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006227793.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGACA GCAAGGCCAA GCCCACCAAA GCTGCCAACA AGACACCACC CAAGTCCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006227855.1 |
CDS | 322..978 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006227793.2 |
1 | ATGGCTGACA GCAAGGCCAA GCCCACCAAA GCTGCCAACA AGACACCACC CAAGTCCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa07376 | |
Clone ID Related Accession (Same CDS sequence) | XM_006227793.2 , NM_001108461.1 , XM_006227794.2 | |
Accession Version | XM_006227794.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | tubulin polymerization-promoting protein isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005100.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 7, 2014 this sequence version replaced XM_006227794.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGACA GCAAGGCCAA GCCCACCAAA GCTGCCAACA AGACACCACC CAAGTCCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006227856.1 |
CDS | 253..909 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006227794.2 |
1 | ATGGCTGACA GCAAGGCCAA GCCCACCAAA GCTGCCAACA AGACACCACC CAAGTCCCCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Tubulin polymerization-promoting protein (TPPP/p25?) promotes unconventional secretion of ?-synuclein through exophagy by impairing autophagosome-lysosome fusion. |
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. |
Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation. |
The expression of tubulin polymerization promoting protein TPPP/p25alpha is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress. |