| Gene Symbol | Dot1l |
| Entrez Gene ID | 362831 |
| Full Name | DOT1 like histone lysine methyltransferase |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome |
The following Dot1l gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Dot1l cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa42257 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001108733.1 | |
| Accession Version | NM_001108733.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4650bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-05-27 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | histone-lysine N-methyltransferase, H3 lysine-79 specific | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474029.1. On or before Oct 4, 2007 this sequence version replaced XM_343159.3, XM_001071372.1. | |
1 | ATGGGCGAGA AGCTGGAGCT GAGGCTCAAG TCGCCTGTGG GCGCGGAGCC CGCCGTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001102203.1 |
| CDS | 240..4889 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001108733.1 |
1 | ATGGGCGAGA AGCTGGAGCT GAGGCTCAAG TCGCCTGTGG GCGCGGAGCC CGCCGTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa29887 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006240961.3 | |
| Accession Version | XM_006240961.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4623bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X2 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240961.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGCGAGA AGCTGGAGCT GAGGCTCAAG TCGCCTGTGG GCGCGGAGCC CGCCGTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006241023.1 |
| CDS | 235..4857 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006240961.3 |
1 | ATGGGCGAGA AGCTGGAGCT GAGGCTCAAG TCGCCTGTGG GCGCGGAGCC CGCCGTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa29886 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006240960.3 , XM_006240959.3 | |
| Accession Version | XM_006240960.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 5211bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240960.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGCGAGA AGCTGGAGCT GAGGCTCAAG TCGCCTGTGG GCGCGGAGCC CGCCGTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006241022.1 |
| CDS | 235..5445 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006240960.3 |
1 | ATGGGCGAGA AGCTGGAGCT GAGGCTCAAG TCGCCTGTGG GCGCGGAGCC CGCCGTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa29886 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006240960.3 , XM_006240959.3 | |
| Accession Version | XM_006240959.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 5211bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006240959.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGCGAGA AGCTGGAGCT GAGGCTCAAG TCGCCTGTGG GCGCGGAGCC CGCCGTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006241021.1 |
| CDS | 235..5445 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006240959.3 |
1 | ATGGGCGAGA AGCTGGAGCT GAGGCTCAAG TCGCCTGTGG GCGCGGAGCC CGCCGTCTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | ORa62036 | |
| Clone ID Related Accession (Same CDS sequence) | XM_017594910.1 | |
| Accession Version | XM_017594910.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 4563bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-07-25 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X3 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005106.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCTGGAGC GAGGTGACTT CCTCTCAGAG GAGTGGAGGG AACGGATCGC CAACACGAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_017450399.1 |
| CDS | 1323..5885 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_017594910.1 |
1 | ATGCTGGAGC GAGGTGACTT CCTCTCAGAG GAGTGGAGGG AACGGATCGC CAACACGAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. |
Histone lysine methylation dynamics: establishment, regulation, and biological impact. |
Targeting protein lysine methylation and demethylation in cancers. |
A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression. |
Modulation of p53 function by SET8-mediated methylation at lysine 382. |
