Gene Symbol | Myl2 |
Entrez Gene ID | 363925 |
Full Name | myosin light chain 2 |
Synonyms | MLC-2s/v,Mlc-2,Mlc2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Myl2 cDNA ORF clone
Gene Symbol | Myl2 |
Entrez Gene ID | 363925 |
Full Name | myosin light chain 2 |
Synonyms | MLC-2s/v,Mlc-2,Mlc2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001035252.2 | NP_001030329.2 | myosin regulatory light chain 2, ventricular/cardiac muscle isoform |
Rattus norvegicus (Norway rat) | Myl2 | NP_001030329.2 |
Gallus gallus (chicken) | MYL2 | NP_001258858.1 |
Canis lupus familiaris (dog) | MYL2 | NP_001003069.1 |
Danio rerio (zebrafish) | myl2b | NP_001035134.1 |
Danio rerio (zebrafish) | LOC100537244 | XP_003198611.2 |
Xenopus tropicalis (tropical clawed frog) | myl2 | NP_001107717.1 |
Pan troglodytes (chimpanzee) | MYL2 | XP_001144828.2 |
Mus musculus (house mouse) | Myl2 | NP_034991.3 |
Bos taurus (cattle) | MYL2 | NP_001030197.1 |
Homo sapiens (human) | MYL2 | NP_000423.2 |
MYL2 | XP_001100796.1 |
Cyclical compressive stress induces differentiation of rat primary mandibular condylar chondrocytes through phosphorylated myosin light chain II.
Liu L, Chen L, Mai Z, Peng Z, Yu K, Liu G, Ai H
Molecular medicine reports14(5)4293-4300(2016 Nov)
A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis.
Wijnker PJ, Li Y, Zhang P, Foster DB, dos Remedios C, Van Eyk JE, Stienen GJ, Murphy AM, van der Velden J
Journal of molecular and cellular cardiology8293-103(2015 May)
Nuclear cardiac myosin light chain 2 modulates NADPH oxidase 2 expression in myocardium: a novel function beyond muscle contraction.
Zhang YS, Liu B, Luo XJ, Li TB, Zhang JJ, Peng JJ, Zhang XJ, Ma QL, Hu CP, Li YJ, Peng J, Li Q
Basic research in cardiology110(4)38(2015)
Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats.
Wen JJ, Garg NJ
Molecular & cellular proteomics : MCP11(4)M111.010918(2012 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Silencing MLCII by RNA interference reduced ALP activity (P<0.01), and eliminated RUNX2 mRNA expression (P<0.01). Addition of the MLC kinase inhibitor, ML7, reduced the CUCSassociated upregulation of RUNX2 expression (P<0.01) and ALP activity (P<0.01).
Title: Cyclical compressive stress induces differentiation of rat primary mandibular condylar chondrocytes through phosphorylated myosin light chain II.
nuclear MYL2 plays an important role in IR injury by transcriptionally upregulating NOX2 expression to enhance oxidative stress in a phosphorylation-dependent manner.
Title: Nuclear cardiac myosin light chain 2 modulates NADPH oxidase 2 expression in myocardium: a novel function beyond muscle contraction.
We have identified three protein biomarkers (GSN, MYL2, and VIM) that have potential utility in diagnosing the severity of Chagas disease
Title: Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats.
Prostanoid F receptor (FPR) signalling mechanism(s) regulating myosin light chain-2 phosphorylation likely extend beyond those classically established for G(q/11)-coupled receptors.
Title: Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation.
The following Myl2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Myl2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa42855 | |
Clone ID Related Accession (Same CDS sequence) | NM_001035252.2 | |
Accession Version | NM_001035252.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | myosin regulatory light chain 2, ventricular/cardiac muscle isoform | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC126064.1. On May 10, 2012 this sequence version replaced NM_001035252.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC126064.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCACCAA AGAAAGCCAA GAAGAGGTTA GAGGGCGGAA GCTCCAACGT GTTCTCCATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001030329.2 |
CDS | 30..530 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001035252.2 |
1 | ATGTCACCAA AGAAAGCCAA GAAGAGGTTA GAGGGCGGAA GCTCCAACGT GTTCTCCATG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Cyclical compressive stress induces differentiation of rat primary mandibular condylar chondrocytes through phosphorylated myosin light chain II. |
A novel phosphorylation site, Serine 199, in the C-terminus of cardiac troponin I regulates calcium sensitivity and susceptibility to calpain-induced proteolysis. |
Nuclear cardiac myosin light chain 2 modulates NADPH oxidase 2 expression in myocardium: a novel function beyond muscle contraction. |
Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats. |