Gene Symbol | Cadm4 |
Entrez Gene ID | 365216 |
Full Name | cell adhesion molecule 4 |
Synonyms | Igsf4c,Necl-4,Upar |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Cadm4 cDNA ORF clone
Gene Symbol | Cadm4 |
Entrez Gene ID | 365216 |
Full Name | cell adhesion molecule 4 |
Synonyms | Igsf4c,Necl-4,Upar |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001047107.1 | NP_001040572.1 | cell adhesion molecule 4 precursor |
Danio rerio (zebrafish) | cadm4 | NP_001007429.1 |
Pan troglodytes (chimpanzee) | CADM4 | XP_512719.4 |
Canis lupus familiaris (dog) | CADM4 | XP_541580.3 |
Bos taurus (cattle) | CADM4 | XP_002695203.2 |
Rattus norvegicus (Norway rat) | Cadm4 | NP_001040572.1 |
Homo sapiens (human) | CADM4 | NP_660339.1 |
Mus musculus (house mouse) | Cadm4 | NP_694752.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100488420 | XP_002939173.1 |
Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis
Heffernan C, Jain MR, Liu T, Kim H, Barretto K, Li H, Maurel P
The Journal of biological chemistry292(11)4484-4498(2017 03)
The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation.
Yamana S, Tokiyama A, Mizutani K, Hirata K, Takai Y, Rikitake Y
PloS one10(4)e0124259(2015)
Interaction of Necl-4/CADM4 with ErbB3 and integrin ?6 ?4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly.
Sugiyama H, Mizutani K, Kurita S, Okimoto N, Shimono Y, Takai Y
Genes to cells : devoted to molecular & cellular mechanisms18(6)519-28(2013 Jun)
Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination.
Maurel P, Einheber S, Galinska J, Thaker P, Lam I, Rubin MB, Scherer SS, Murakami Y, Gutmann DH, Salzer JL
The Journal of cell biology178(5)861-74(2007 Aug)
A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination.
Spiegel I, Adamsky K, Eshed Y, Milo R, Sabanay H, Sarig-Nadir O, Horresh I, Scherer SS, Rasband MN, Peles E
Nature neuroscience10(7)861-9(2007 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Intracellular choline levels are significantly elevated in NECL4-deficient Schwann cells.
Title: Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis
These results demonstrate a key role for Necl, 2 and 4 in initiating peripheral nervous system myelination and implicate the Necl proteins as mediators of axo-glial interactions along the internode.
Title: Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination.
Necl4 protein is important for mediating axon-glia contact during myelination in peripheral nerves
Title: A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination.
The following Cadm4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cadm4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa09846 | |
Clone ID Related Accession (Same CDS sequence) | NM_001047107.1 | |
Accession Version | NM_001047107.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1167bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | cell adhesion molecule 4 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ272745.1. On or before Sep 7, 2006 this sequence version replaced XM_001059474.1, XM_001076576.1. ##Evidence-Data-START## Transcript exon combination :: DQ272745.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGGCCGGG CCCGGCGCTT CCAGTGGCCG CTGCTGCTAC TGTGGGCGGC CGCGGCGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001040572.1 |
CDS | 1..1167 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001047107.1 |
1 | ATGGGCCGGG CCCGGCGCTT CCAGTGGCCG CTGCTGCTAC TGTGGGCGGC CGCGGCGGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Nectin-like 4 Complexes with Choline Transporter-like Protein-1 and Regulates Schwann Cell Choline Homeostasis and Lipid Biogenesis |
The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation. |
Interaction of Necl-4/CADM4 with ErbB3 and integrin ?6 ?4 and inhibition of ErbB2/ErbB3 signaling and hemidesmosome disassembly. |
Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination. |
A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. |