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Vkorc1l1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Vkorc1l1
Entrez Gene ID 399684
Full Name vitamin K epoxide reductase complex, subunit 1-like 1
General protein information
Preferred Names

vitamin K epoxide reductase complex, subunit 1-like 1

Names

vitamin K epoxide reductase complex subunit 1-like protein 1
VKORC1-like protein 1
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

12

12q12-q13

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_017598418.1 XP_017453907.1 vitamin K epoxide reductase complex subunit 1-like protein 1 isoform X1
NM_203338.1 NP_976083.1 vitamin K epoxide reductase complex subunit 1-like protein 1

Pathways from BioSystems


Homologies


Mus musculus (house mouse) Vkorc1l1 NP_081397.1
Homo sapiens (human) VKORC1L1 NP_775788.2
Pan troglodytes (chimpanzee) VKORC1L1 XP_527770.2
VKORC1L1 XP_001088069.1
Bos taurus (cattle) VKORC1L1 XP_002698121.1
Rattus norvegicus (Norway rat) Vkorc1l1 NP_976083.1
Xenopus tropicalis (tropical clawed frog) vkorc1l1 NP_001016769.2
Canis lupus familiaris (dog) VKORC1L1 XP_848485.1
Gallus gallus (chicken) VKORC1L1 NP_001001328.1
Danio rerio (zebrafish) vkorc1l1 NP_001018524.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP000543 XP_310541.3

Gene Ontology


Bibliography

Related articles in PubMed

Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration.
Tie JK, Jin DY, Stafford DW
The Journal of biological chemistry289(13)9396-407(2014 Mar)

VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
Hammed A, Matagrin B, Spohn G, Prouillac C, Benoit E, Lattard V
The Journal of biological chemistry288(40)28733-42(2013 Oct)

Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function.
Westhofen P, Watzka M, Marinova M, Hass M, Kirfel G, M?ller J, Bevans CG, M?ller CR, Oldenburg J
The Journal of biological chemistry286(17)15085-94(2011 Apr)

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Rost S, Fregin A, Ivaskevicius V, Conzelmann E, H?rtnagel K, Pelz HJ, Lappegard K, Seifried E, Scharrer I, Tuddenham EG, M?ller CR, Strom TM, Oldenburg J
Nature427(6974)537-41(2004 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The involvement of VKORC1L1 in VKOR activity partly explains the low susceptibility of some extrahepatic tissues to vitamin K antagonists.
Title: VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.

molecular cloning
Title: Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.

The following Vkorc1l1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vkorc1l1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa13535 NM_203338.1
Latest version!		 Rattus norvegicus vitamin K epoxide reductase complex, subunit 1-like 1 (Vkorc1l1), mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $69.30
$99.00
ORa52809 XM_017598418.1
Latest version!		 Rattus norvegicus vitamin K epoxide reductase complex, subunit 1-like 1 (Vkorc1l1), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa13535
Clone ID Related Accession (Same CDS sequence) NM_203338.1
Accession Version NM_203338.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 531bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-09-14
Organism Rattus norvegicus(Norway rat)
Product vitamin K epoxide reductase complex subunit 1-like protein 1
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY423048.1. ##Evidence-Data-START## Transcript exon combination :: AY423048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGGT GGGAACGGGT GGCCCGGTAT 
GCAGTGTGCG CCGCCGGGAT CCTGCTCTCC ATCTACGCCT ACCACGTGGA GCGGGAGAAG 
GAGAGGGACC CGGAGCACCG GGCCCTCTGC GACCTGGGGC CCTGGGTGAA GTGCTCCGCC 
GCCCTGGCCT CCAGATGGGG TCGAGGATTT GGTCTTTTGG GTTCCATTTT TGGAAAAGAT 
GGTGTATTAA ACCAGCCAAA CAGTGTCTTT GGACTTATAT TTTATATACT ACAGTTATTA 
CTTGGCATGA CAGCCAGCGC AGTTGCAGCT CTGGTCCTCA TGACCTCCTC CATCGTGTCC 
GTGGTGGGGT CTTTGTACCT GGCCTACATT CTGTACTTTG TGCTGAAGGA GTTTTGCATC 
ATCTGCGTCA CCACATATGT GCTGAACTTC CTTCTCCTCA TCATCAACTA CAAACGACTG 
GTTTACTTGA ATGAGGCCTG GAAGCGACAA CTGCAGCCTA AGGAAGACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_976083.1
CDS51..581
Translation

Target ORF information:

RefSeq Version NM_203338.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus vitamin K epoxide reductase complex, subunit 1-like 1 (Vkorc1l1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_203338.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGGT GGGAACGGGT GGCCCGGTAT 
GCAGTGTGCG CCGCCGGGAT CCTGCTCTCC ATCTACGCCT ACCACGTGGA GCGGGAGAAG 
GAGAGGGACC CGGAGCACCG GGCCCTCTGC GACCTGGGGC CCTGGGTGAA GTGCTCCGCC 
GCCCTGGCCT CCAGATGGGG TCGAGGATTT GGTCTTTTGG GTTCCATTTT TGGAAAAGAT 
GGTGTATTAA ACCAGCCAAA CAGTGTCTTT GGACTTATAT TTTATATACT ACAGTTATTA 
CTTGGCATGA CAGCCAGCGC AGTTGCAGCT CTGGTCCTCA TGACCTCCTC CATCGTGTCC 
GTGGTGGGGT CTTTGTACCT GGCCTACATT CTGTACTTTG TGCTGAAGGA GTTTTGCATC 
ATCTGCGTCA CCACATATGT GCTGAACTTC CTTCTCCTCA TCATCAACTA CAAACGACTG 
GTTTACTTGA ATGAGGCCTG GAAGCGACAA CTGCAGCCTA AGGAAGACTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa52809
Clone ID Related Accession (Same CDS sequence) XM_017598418.1
Accession Version XM_017598418.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 384bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product vitamin K epoxide reductase complex subunit 1-like protein 1 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005111.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGGT GGGAACGGGT GGCCCGGTAT 
GCAGTGTGCG CCGCCGGGAT CCTGCTCTCC ATCTACGCCT ACCACGTGGA GCGGGAGAAG 
GAGAGGGACC CGGAGCACCG GGCCCTCTGC GACCTGGGGC CCTGGGTGAA GTGCTCCGCC 
GCCCTGGCCT CCAGGCATGA CAGCCAGCGC AGTTGCAGCT CTGGTCCTCA TGACCTCCTC 
CATCGTGTCC GTGGTGGGGT CTTTGTACCT GGCCTACATT CTGTACTTTG TGCTGAAGGA 
GTTTTGCATC ATCTGCGTCA CCACATATGT GCTGAACTTC CTTCTCCTCA TCATCAACTA 
CAAACGACTG GTTTACTTGA ATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_017453907.1
CDS44..427
Translation

Target ORF information:

RefSeq Version XM_017598418.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus vitamin K epoxide reductase complex, subunit 1-like 1 (Vkorc1l1), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017598418.1

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGCGGCGC CCGTCCTGCT GAGAGTGTCG GTGCCGCGGT GGGAACGGGT GGCCCGGTAT 
GCAGTGTGCG CCGCCGGGAT CCTGCTCTCC ATCTACGCCT ACCACGTGGA GCGGGAGAAG 
GAGAGGGACC CGGAGCACCG GGCCCTCTGC GACCTGGGGC CCTGGGTGAA GTGCTCCGCC 
GCCCTGGCCT CCAGGCATGA CAGCCAGCGC AGTTGCAGCT CTGGTCCTCA TGACCTCCTC 
CATCGTGTCC GTGGTGGGGT CTTTGTACCT GGCCTACATT CTGTACTTTG TGCTGAAGGA 
GTTTTGCATC ATCTGCGTCA CCACATATGT GCTGAACTTC CTTCTCCTCA TCATCAACTA 
CAAACGACTG GTTTACTTGA ATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Conserved loop cysteines of vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) are involved in its active site regeneration.
The Journal of biological chemistry289(13)9396-407(2014 Mar)
Tie JK,Jin DY,Stafford DW


book

VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy.
The Journal of biological chemistry288(40)28733-42(2013 Oct)
Hammed A,Matagrin B,Spohn G,Prouillac C,Benoit E,Lattard V


book

Human vitamin K 2,3-epoxide reductase complex subunit 1-like 1 (VKORC1L1) mediates vitamin K-dependent intracellular antioxidant function.
The Journal of biological chemistry286(17)15085-94(2011 Apr)
Westhofen P,Watzka M,Marinova M,Hass M,Kirfel G,M?ller J,Bevans CG,M?ller CR,Oldenburg J


book

Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.
Nature427(6974)537-41(2004 Feb)
Rost S,Fregin A,Ivaskevicius V,Conzelmann E,H?rtnagel K,Pelz HJ,Lappegard K,Seifried E,Scharrer I,Tuddenham EG,M?ller CR,Strom TM,Oldenburg J