Gene Symbol | Eif2a |
Entrez Gene ID | 502531 |
Full Name | eukaryotic translation initiation factor 2A |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
ORF » Species Summary » Rattus norvegicus » Eif2a cDNA ORF clone
gRNAs
Gene Symbol | Eif2a |
Entrez Gene ID | 502531 |
Full Name | eukaryotic translation initiation factor 2A |
General protein information |
|
Gene Type | protein-coding |
Organism | Rattus norvegicus(Norway rat) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006232388.3 | XP_006232450.1 | eukaryotic translation initiation factor 2A isoform X1 |
XM_017591051.1 | XP_017446540.1 | eukaryotic translation initiation factor 2A isoform X2 |
NM_001109339.1 | NP_001102809.1 | eukaryotic translation initiation factor 2A |
Homo sapiens (human) | EIF2A | NP_114414.2 |
Pan troglodytes (chimpanzee) | EIF2A | XP_001143578.1 |
Canis lupus familiaris (dog) | EIF2A | XP_534306.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002525 | XP_312412.4 |
Caenorhabditis elegans (roundworm) | E04D5.1 | NP_496239.2 |
Schizosaccharomyces pombe (fission yeast) | SPBC4B4.04 | NP_596421.1 |
Bos taurus (cattle) | EIF2A | NP_001095753.1 |
Drosophila melanogaster (fruit fly) | CG7414 | NP_649365.1 |
EIF2A | XP_001108004.2 | |
Mus musculus (house mouse) | Eif2a | NP_001005509.1 |
Saccharomyces cerevisiae (baker's yeast) | YGR054W | NP_011568.3 |
Eremothecium gossypii | AGOS_AEL286C | NP_984574.2 |
Arabidopsis thaliana (thale cress) | AT1G73180 | NP_565058.1 |
Kluyveromyces lactis | KLLA0A02761g | XP_451122.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_00847 | XP_003718132.1 |
Neurospora crassa | NCU06099 | XP_959961.1 |
Xenopus tropicalis (tropical clawed frog) | eif2a | NP_001120561.1 |
Rattus norvegicus (Norway rat) | Eif2a | NP_001102809.1 |
Gallus gallus (chicken) | EIF2A | NP_001026494.1 |
Danio rerio (zebrafish) | eif2a | NP_001020341.1 |
Astragaloside-IV Alleviates Heat-Induced Inflammation by Inhibiting Endoplasmic Reticulum Stress and Autophagy.
Dong Z, Zhou J, Zhang Y, Chen Y, Yang Z, Huang G, Chen Y, Yuan Z, Peng Y, Cao T
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology42(2)824-837(2017)
The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha.
Hong MN, Nam KY, Kim KK, Kim SY, Kim I
Cell stress & chaperones21(3)485-97(2016 May)
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)
Regulation of autophagy via PERK-eIF2? effectively relieve the radiation myelitis induced by iodine-125.
Yang Z, Xu Y, Xu L, Maccauro G, Rossi B, Chen Y, Li H, Zhang J, Sun H, Yang Y, Xu D, Liu X
PloS one8(11)e76819(2013)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
AS-IV may attenuate inflammatory responses by disrupting the crosstalk between autophagy and the PERK-eIF2alpha pathway and may be an ideal agent for treating inflammatory pulmonary diseases.
Title: Astragaloside-IV Alleviates Heat-Induced Inflammation by Inhibiting Endoplasmic Reticulum Stress and Autophagy.
We suggest from these data that AMC-01 and its derivative compounds can be used as chemical probes in future studies of the role of eIF2-alpha in protein synthesis-related cell physiology.
Title: The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha.
In an endoplasmic reticulum-stressed rat brain model, eif2a is phosphorylated via the PERK signal pathway.
Title: ?-Synuclein is involved in manganese-induced ER stress via PERK signal pathway in organotypic brain slice cultures.
Autophagy induced by (125)I radiation was involved in endoplasmic reticulum stress and mainly dependent on PERK-eIF2alpha pathway.
Title: Regulation of autophagy via PERK-eIF2? effectively relieve the radiation myelitis induced by iodine-125.
hyperoxia-induced suppression of mRNA translation in the newborn lung is accompanied by increased phosphorylation of eIF2alpha in the epithelium
Title: Hyperoxia inhibits protein synthesis and increases eIF2? phosphorylation in the newborn rat lung.
The following Eif2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eif2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | ORa09658 | |
Clone ID Related Accession (Same CDS sequence) | NM_001109339.1 | |
Accession Version | NM_001109339.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1626bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-11-11 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | eukaryotic translation initiation factor 2A | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH474003.2. On or before Oct 4, 2007 this sequence version replaced XM_001058163.1, XM_578017.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA2689604, SAMEA2689605 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGACCCCC ACACTTCACA GAGAGCACAG TGCTTCCAAG AGAACCTGGA AAAAATTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001102809.1 |
CDS | 79..1704 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGACCCCC ACACTTCACA GAGAGCACAG TGCTTCCAAG AGAACCTGGA AAAAATTGCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa24707 | |
Clone ID Related Accession (Same CDS sequence) | XM_006232388.3 | |
Accession Version | XM_006232388.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1770bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | eukaryotic translation initiation factor 2A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006232388.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGTTTCT CTTTCCGGGA CAAGATGGCG CCGTCCACAC CGCTGTTGAC AGTCAGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006232450.1 |
CDS | 86..1855 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGTTTCT CTTTCCGGGA CAAGATGGCG CCGTCCACAC CGCTGTTGAC AGTCAGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | ORa59837 | |
Clone ID Related Accession (Same CDS sequence) | XM_017591051.1 | |
Accession Version | XM_017591051.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-07-25 | |
Organism | Rattus norvegicus(Norway rat) | |
Product | eukaryotic translation initiation factor 2A isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005101.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCAGAATT GGTGTCCTTC CTGGTCAGAT GATGAAATTA TTTGTGCCCG GAATGTTAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017446540.1 |
CDS | 381..1745 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCAGAATT GGTGTCCTTC CTGGTCAGAT GATGAAATTA TTTGTGCCCG GAATGTTAAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Astragaloside-IV Alleviates Heat-Induced Inflammation by Inhibiting Endoplasmic Reticulum Stress and Autophagy. |
The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha. |
E-cadherin interactome complexity and robustness resolved by quantitative proteomics. |
Regulation of autophagy via PERK-eIF2? effectively relieve the radiation myelitis induced by iodine-125. |