Hes5 cDNA ORF clone, Rattus norvegicus(Norway rat)
| Gene Symbol | Hes5 |
| Entrez Gene ID | 79225 |
| Full Name | hes family bHLH transcription factor 5 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Rattus norvegicus(Norway rat) |
| Genome | |
| Summary | basic helix-loop-helix (HLH) protein; may function as negative regulator in neural development [RGD, Feb 2006]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_024383.1 | NP_077359.1 | transcription factor HES-5 |
| Danio rerio (zebrafish) | LOC100149066 | NP_001121862.1 |
| Homo sapiens (human) | HES5 | NP_001010926.1 |
| Mus musculus (house mouse) | Hes5 | NP_034549.1 |
| Danio rerio (zebrafish) | her4.2 | NP_571165.3 |
| Danio rerio (zebrafish) | her4.3 | NP_001154880.1 |
| Xenopus tropicalis (tropical clawed frog) | hes5 | XP_004916212.1 |
| Pan troglodytes (chimpanzee) | HES5 | XP_524847.2 |
| Canis lupus familiaris (dog) | HES5 | XP_546734.2 |
| Bos taurus (cattle) | HES5 | NP_001098937.1 |
| Rattus norvegicus (Norway rat) | Hes5 | NP_077359.1 |
| Gallus gallus (chicken) | HES5 | NP_001012713.1 |
| Xenopus tropicalis (tropical clawed frog) | hes5.1 | NP_001037880.1 |
| Danio rerio (zebrafish) | LOC100149863 | NP_001096598.1 |
| Danio rerio (zebrafish) | LOC100148329 | NP_001154881.1 |
Related articles in PubMed
Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway.
Li W, Wu J, Yang J, Sun S, Chai R, Chen ZY, Li H
Proceedings of the National Academy of Sciences of the United States of America112(1)166-71(2015 Jan)
Folic acid enhances Notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia.
Zhang X, Huang G, Liu H, Chang H, Wilson JX
Nutritional neuroscience15(2)55-61(2012 Mar)
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development.
Tateya T, Imayoshi I, Tateya I, Ito J, Kageyama R
Developmental biology352(2)329-40(2011 Apr)
HeyL promotes neuronal differentiation of neural progenitor cells.
Jalali A, Bassuk AG, Kan L, Israsena N, Mukhopadhyay A, McGuire T, Kessler JA
Journal of neuroscience research89(3)299-309(2011 Mar)
Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain.
Shimizu T, Nakazawa M, Kani S, Bae YK, Shimizu T, Kageyama R, Hibi M
Development (Cambridge, England)137(11)1875-85(2010 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Folic acid stimulated the expression of Notch1, Hes1, and Hes5 proteins, and this effect increased with folic acid dose in the rat middle cerebral artery occlusion model of stroke.
Title: Folic acid enhances Notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia.
Hes5 was not expressed on postnatal days 0 - 5 in rat greater epithelial ridge cells.
Title: [Expression of three kinds of transcription factors in greater epithelial ridge cells of rat cochlear].
The levels of Hes5 mRNA decreased on days 1 and 3 after the start of reperfusion and the decreased levels of the mRNA returned to the basal level by 5 days after ischemia.
Title: Changes in the expression of Hes5 and Mash1 mRNA in the adult rat dentate gyrus after transient forebrain ischemia.
Hes5 does not promote astrocyte differentiation
Title: Hes1 but not Hes5 regulates an astrocyte versus oligodendrocyte fate choice in glial restricted precursors.
The following Hes5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hes5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | ORa06998 | |
| Clone ID Related Accession (Same CDS sequence) | NM_024383.1 | |
| Accession Version | NM_024383.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-09-14 | |
| Organism | Rattus norvegicus(Norway rat) | |
| Product | transcription factor HES-5 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D12516.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D12516.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCCCCAA GTACCGTGGC GGTGGAGATG CTCAGTCCCA AGGAGAAAAA TCGACTGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_077359.1 |
| CDS | 53..553 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_024383.1 |
ORF Insert Sequence:
1 | ATGGCCCCAA GTACCGTGGC GGTGGAGATG CTCAGTCCCA AGGAGAAAAA TCGACTGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Notch inhibition induces mitotically generated hair cells in mammalian cochleae via activating the Wnt pathway. |
|
Folic acid enhances Notch signaling, hippocampal neurogenesis, and cognitive function in a rat model of cerebral ischemia. |
|
Cooperative functions of Hes/Hey genes in auditory hair cell and supporting cell development. |
|
HeyL promotes neuronal differentiation of neural progenitor cells. |
|
Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain. |