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Fcna cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Fcna
Entrez Gene ID 83517
Full Name ficolin A
Synonyms Fcn1
General protein information
Preferred Names

ficolin A

Names

ficolin-1
M-ficolin
collagen/fibrinogen domain-containing protein 1
ficolin (collagen/fibrinogen domain containing) 1
ficolin-alpha
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

3

3p13
Summary mouse homolog is a plasma protein that binds elastin and GlcNAc [RGD, Feb 2006].

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_008761614.1 XP_008759836.1 ficolin-1 isoform X1
NM_031348.2 NP_112638.2 ficolin-1 precursor

Pathways from BioSystems


Homologies


Rattus norvegicus (Norway rat) Fcn1 NP_112638.2
Mus musculus (house mouse) Fcna NP_032021.1

Gene Ontology


Bibliography

Related articles in PubMed

Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans.
Schelenz S, Kirchhof N, Bidula S, Wallis R, Sexton DW
Immunobiology218(4)477-83(2013 Apr)

Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses.
Verma A, White M, Vathipadiekal V, Tripathi S, Mbianda J, Ieong M, Qi L, Taubenberger JK, Takahashi K, Jensenius JC, Thiel S, Hartshorn KL
Journal of immunology (Baltimore, Md. : 1950)189(5)2478-87(2012 Sep)

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Bastos-Amador P, Royo F, Gonzalez E, Conde-Vancells J, Palomo-Diez L, Borras FE, Falcon-Perez JM
Journal of proteomics75(12)3574-84(2012 Jun)

Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins.
Girija UV, Dodds AW, Roscher S, Reid KB, Wallis R
Journal of immunology (Baltimore, Md. : 1950)179(1)455-62(2007 Jul)

Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP.
Endo Y, Nakazawa N, Liu Y, Iwaki D, Takahashi M, Fujita T, Nakata M, Matsushita M
Immunogenetics57(11)837-44(2005 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ficolin-A binds acapsular C. neoformans via their carbohydrate recognizing fibrinogen-like domains leading to enhanced uptake by lung epithelial cells in vitro.
Title: Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans.

The mannose-binding lectin (MBL)-associated-serine protease (MASP)-2 binding site on rat ficolin-A is located within the collagen-like domain and encompasses a conserved motif that is present in both MBLs and ficolins.
Title: Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins.

The following Fcna gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fcna cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa07884 NM_031348.2
Latest version!		 Rattus norvegicus ficolin A (Fcna), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
ORa43760 XM_008761614.1
Latest version!		 Rattus norvegicus ficolin A (Fcna), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone 40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa07884
Clone ID Related Accession (Same CDS sequence) NM_031348.2
Accession Version NM_031348.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1008bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-24
Organism Rattus norvegicus(Norway rat)
Product ficolin-1 precursor
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC088128.1. On Jan 2, 2005 this sequence version replaced NM_031348.1. ##Evidence-Data-START## Transcript exon combination :: BC088128.1, AB026057.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906358 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTGGTGGC CTATGCTGTG GGCCTTTCCA GTACTGCTCT GTCTCTGTTC CTCCCAGGCC 
CTGGGTCAGG AGAGTGGTGC CTGTCCAGAT GTTAAGATCG TAGGTCTGGG GGCCCAGGAC 
AAGGTGGCTG TCATCCAAAG TTGCCCTAGC TTTCCTGGCC CACCTGGACC CAAAGGGGAG 
CCTGGAAGTC CTGCTGGGAG AGGGGAACGG GGCTTACAGG GCAGCCCAGG GAAGATGGGA 
CCCGCCGGCA GCAAAGGAGA GCCAGGAACC ATGGGGCCCC CAGGAGTCAA AGGGGAGAAA 
GGAGAGAGAG GAACTGCATC ACCACTGGGT CAGAAGGAGC TGGGAGACGC ACTGTGCCGG 
AGAGGGCCCC GGAGCTGCAA AGACTTGCTG ACACGGGGGA TCTTCCTGAC TGGCTGGTAC 
ACCATCTATC TTCCTGACTG CCGGCCACTG ACTGTGCTCT GTGACATGGA TGTGGATGGT 
GGGGGCTGGA CCGTTTTTCA ACGACGAGTG GATGGGTCCA TCAACTTCTA CCGAGACTGG 
GATTCCTATA AAAGAGGCTT TGGCAACCTG GGCACAGAGT TCTGGTTGGG TAATGACTAC 
CTTCACCTGC TCACAGCCAA TGGGAACCAA GAGCTCCGGG TTGACTTAAG AGAGTTCCAA 
GGTCAAACCT CCTTTGCCAA ATACAGCTCA TTCCAGGTAT CTGGAGAACA GGAGAAATAC 
AAGCTGACCT TGGGGCAGTT TCTGGAGGGC ACTGCAGGAG ACTCCCTGAC AAAGCACAAC 
AACATGGCAT TCTCAACTCA TGACCAAGAT AATGATACGA ATGGCGGGAA GAACTGTGCA 
GCTTTGTTCC ACGGAGCCTG GTGGTACCAC GACTGTCACC AGTCCAACCT CAACGGGCGC 
TACTTGCCTG GCTCCCATGA AAGTTATGCG GATGGCATCA ACTGGCTAAG TGGCCGAGGC 
CACCGCTACT CCTACAAGGT TGCTGAGATG AAAATCCGGG CATCATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_112638.2
CDS94..1101
Translation

Target ORF information:

RefSeq Version NM_031348.2
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus ficolin A (Fcna), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_031348.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTGGTGGC CTATGCTGTG GGCCTTTCCA GTACTGCTCT GTCTCTGTTC CTCCCAGGCC 
CTGGGTCAGG AGAGTGGTGC CTGTCCAGAT GTTAAGATCG TAGGTCTGGG GGCCCAGGAC 
AAGGTGGCTG TCATCCAAAG TTGCCCTAGC TTTCCTGGCC CACCTGGACC CAAAGGGGAG 
CCTGGAAGTC CTGCTGGGAG AGGGGAACGG GGCTTACAGG GCAGCCCAGG GAAGATGGGA 
CCCGCCGGCA GCAAAGGAGA GCCAGGAACC ATGGGGCCCC CAGGAGTCAA AGGGGAGAAA 
GGAGAGAGAG GAACTGCATC ACCACTGGGT CAGAAGGAGC TGGGAGACGC ACTGTGCCGG 
AGAGGGCCCC GGAGCTGCAA AGACTTGCTG ACACGGGGGA TCTTCCTGAC TGGCTGGTAC 
ACCATCTATC TTCCTGACTG CCGGCCACTG ACTGTGCTCT GTGACATGGA TGTGGATGGT 
GGGGGCTGGA CCGTTTTTCA ACGACGAGTG GATGGGTCCA TCAACTTCTA CCGAGACTGG 
GATTCCTATA AAAGAGGCTT TGGCAACCTG GGCACAGAGT TCTGGTTGGG TAATGACTAC 
CTTCACCTGC TCACAGCCAA TGGGAACCAA GAGCTCCGGG TTGACTTAAG AGAGTTCCAA 
GGTCAAACCT CCTTTGCCAA ATACAGCTCA TTCCAGGTAT CTGGAGAACA GGAGAAATAC 
AAGCTGACCT TGGGGCAGTT TCTGGAGGGC ACTGCAGGAG ACTCCCTGAC AAAGCACAAC 
AACATGGCAT TCTCAACTCA TGACCAAGAT AATGATACGA ATGGCGGGAA GAACTGTGCA 
GCTTTGTTCC ACGGAGCCTG GTGGTACCAC GACTGTCACC AGTCCAACCT CAACGGGCGC 
TACTTGCCTG GCTCCCATGA AAGTTATGCG GATGGCATCA ACTGGCTAAG TGGCCGAGGC 
CACCGCTACT CCTACAAGGT TGCTGAGATG AAAATCCGGG CATCATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID ORa43760
Clone ID Related Accession (Same CDS sequence) XM_008761614.1
Accession Version XM_008761614.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 813bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-07-25
Organism Rattus norvegicus(Norway rat)
Product ficolin-1 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005102.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTGGTGGC CTATGCTGTG GGCCTTTCCA GTACTGCTCT GTCTCTGTTC CTCCCAGGCC 
CTGGGTCAGG AGAGTGGTGC CTGTCCAGAT GTTAAGATCG TAGGTCTGGG GGCCCAGGAC 
AAGGTGGCTG TCATCCAAAG TTGCCCTAGC TTTCCTGGCC CACCTGGACC CAAAGGGGAG 
CCTGGAAGTC CTGCTGGGAG AGGGGAACGG GGCTTACAGG GCAGCCCAGG GAAGATGGGA 
CCCGCCGGCA GCAAAGGAGA GCCAGGAACC ATGGGGCCCC CAGGAGTCAA AGGGGAGAAA 
GGAGAGAGAG GAACTGCATC ACCACTGGGT CAGAAGGAGC TGGGAGACGC ACTGTGCCGG 
AGAGGGCCCC GGAGCTGCAA AGACTTGCTG ACACGGGGGA TCTTCCTGAC TGGCTGGTAC 
ACCATCTATC TTCCTGACTG CCGGCCACTG ACTGTGCTCT GTGACATGGA TGTGGATGGT 
GGGGGCTGGA CCGTTTTTCA ACGACGAGTG GATGGGTCCA TCAACTTCTA CCGAGACTGG 
GATTCCTATA AAAGAGGCTT TGGCAACCTG GGCACAGAGT TCTGGTTGGG TAATGACTAC 
CTTCACCTGC TCACAGCCAA TGGGAACCAA GAGCTCCGGG TTGACTTAAG AGAGTTCCAA 
GGTCAAACCT CCTTTGCCAA ATACAGCTCA TTCCAGGTAT CTGGAGAACA GGAGAAATAC 
AAGCTGACCT TGGGGCAGTT TCTGGAGGGC ACTGCAGGTC TTTGCAGGAG ACTCCCTGAC 
AAAGCACAAC AACATGGCAT TCTCAACTCA TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_008759836.1
CDS117..929
Translation

Target ORF information:

RefSeq Version XM_008761614.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus ficolin A (Fcna), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_008761614.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGTGGTGGC CTATGCTGTG GGCCTTTCCA GTACTGCTCT GTCTCTGTTC CTCCCAGGCC 
CTGGGTCAGG AGAGTGGTGC CTGTCCAGAT GTTAAGATCG TAGGTCTGGG GGCCCAGGAC 
AAGGTGGCTG TCATCCAAAG TTGCCCTAGC TTTCCTGGCC CACCTGGACC CAAAGGGGAG 
CCTGGAAGTC CTGCTGGGAG AGGGGAACGG GGCTTACAGG GCAGCCCAGG GAAGATGGGA 
CCCGCCGGCA GCAAAGGAGA GCCAGGAACC ATGGGGCCCC CAGGAGTCAA AGGGGAGAAA 
GGAGAGAGAG GAACTGCATC ACCACTGGGT CAGAAGGAGC TGGGAGACGC ACTGTGCCGG 
AGAGGGCCCC GGAGCTGCAA AGACTTGCTG ACACGGGGGA TCTTCCTGAC TGGCTGGTAC 
ACCATCTATC TTCCTGACTG CCGGCCACTG ACTGTGCTCT GTGACATGGA TGTGGATGGT 
GGGGGCTGGA CCGTTTTTCA ACGACGAGTG GATGGGTCCA TCAACTTCTA CCGAGACTGG 
GATTCCTATA AAAGAGGCTT TGGCAACCTG GGCACAGAGT TCTGGTTGGG TAATGACTAC 
CTTCACCTGC TCACAGCCAA TGGGAACCAA GAGCTCCGGG TTGACTTAAG AGAGTTCCAA 
GGTCAAACCT CCTTTGCCAA ATACAGCTCA TTCCAGGTAT CTGGAGAACA GGAGAAATAC 
AAGCTGACCT TGGGGCAGTT TCTGGAGGGC ACTGCAGGTC TTTGCAGGAG ACTCCCTGAC 
AAAGCACAAC AACATGGCAT TCTCAACTCA TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans.
Immunobiology218(4)477-83(2013 Apr)
Schelenz S,Kirchhof N,Bidula S,Wallis R,Sexton DW


book

Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses.
Journal of immunology (Baltimore, Md. : 1950)189(5)2478-87(2012 Sep)
Verma A,White M,Vathipadiekal V,Tripathi S,Mbianda J,Ieong M,Qi L,Taubenberger JK,Takahashi K,Jensenius JC,Thiel S,Hartshorn KL


book

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
Journal of proteomics75(12)3574-84(2012 Jun)
Bastos-Amador P,Royo F,Gonzalez E,Conde-Vancells J,Palomo-Diez L,Borras FE,Falcon-Perez JM


book

Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins.
Journal of immunology (Baltimore, Md. : 1950)179(1)455-62(2007 Jul)
Girija UV,Dodds AW,Roscher S,Reid KB,Wallis R


book

Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP.
Immunogenetics57(11)837-44(2005 Dec)
Endo Y,Nakazawa N,Liu Y,Iwaki D,Takahashi M,Fujita T,Nakata M,Matsushita M