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Hdac5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Summary

Gene Symbol Hdac5
Entrez Gene ID 84580
Full Name histone deacetylase 5
General protein information
Preferred Names

histone deacetylase 5

Names

histone deacetylase 5
Gene Type protein-coding
Organism Rattus norvegicus(Norway rat)
Genome

10

10q32.1
Summary mouse homolog is involved in mediating nuclear receptor repression [RGD, Feb 2006].

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_053450.1 NP_445902.1 histone deacetylase 5

Pathways from BioSystems


Homologies


Homo sapiens (human) HDAC5 NP_005465.2
Canis lupus familiaris (dog) HDAC5 XP_548064.3
Mus musculus (house mouse) Hdac5 NP_034542.3
HDAC5 XP_002800582.1
Bos taurus (cattle) HDAC5 NP_001033114.2
Danio rerio (zebrafish) LOC557486 XP_685659.5
Pan troglodytes (chimpanzee) HDAC5 XP_003315458.1
Rattus norvegicus (Norway rat) Hdac5 NP_445902.1
Xenopus tropicalis (tropical clawed frog) hdac5 XP_002935586.2

Gene Ontology


Bibliography

Related articles in PubMed

HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.
Taniguchi M, Carreira MB, Cooper YA, Bobadilla AC, Heinsbroek JA, Koike N, Larson EB, Balmuth EA, Hughes BW, Penrod RD, Kumar J, Smith LN, Guzman D, Takahashi JS, Kim TK, Kalivas PW, Self DW, Lin Y, Cowan CW
Neuron96(1)130-144.e6(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

nuclear histone deacetylase 5 (HDAC5) in the nucleus accumbens (NAc) reduced cocaine reward-context associations and relapse-like behaviors in a cocaine self-administration model. We also discovered that HDAC5 associates with an activity-sensitive enhancer of the Npas4 gene and negatively regulates NPAS4 expression.
Title: HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.

beta-AR stimulation induces HDAC5 nuclear accumulation in cardiomyocytes by a mechanism that is protein kinase A-dependent but requires B55alpha-PP2A-mediated dephosphorylation of Ser259/Ser498.
Title: ?-Adrenergic Stimulation Induces Histone Deacetylase 5 (HDAC5) Nuclear Accumulation in Cardiomyocytes by B55?-PP2A-Mediated Dephosphorylation.

Both HDAC5 and p300 are involved in MRTF-A-mediated effect on neuronal apoptosis.
Title: Opposite effects of HDAC5 and p300 on MRTF-A-related neuronal apoptosis during ischemia/reperfusion injury in rats.

while alphaTAT1 may be important for axonal growth in vitro, neither alphaTAT1 nor HDAC5 had an effect in vivo on the regeneration of sciatic nerves.
Title: Effects of ?TAT1 and HDAC5 on axonal regeneration in adult neurons.

Taken together, our results reveal that EPO and cEPO mediate MEF2 target gene expression via the regulation of HDAC5 phosphorylation at Ser259/498, and suggest that HDAC5 could be a mechanism contributing to the therapeutic actions of EPO and cEPO.
Title: Erythropoietin and carbamylated erythropoietin promote histone deacetylase 5 phosphorylation and nuclear export in rat hippocampal neurons.

The following Hdac5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hdac5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
ORa09608 NM_053450.1
Latest version!		 Rattus norvegicus histone deacetylase 5 (Hdac5), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $559.30
$799.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID ORa09608
Clone ID Related Accession (Same CDS sequence) NM_053450.1
Accession Version NM_053450.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 3342bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-15
Organism Rattus norvegicus(Norway rat)
Product histone deacetylase 5
Comment Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473948.1. On Dec 17, 2009 this sequence version replaced XM_001081495.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
ATGAACTCTC CCAACGAGTC GGATGGCATG TCAGGCCGGG AACCATCCTT GGAAATCTTG 
CCACGGACTC CTCTGCACAG CATCCCTGTG GCAGTGGAGG TGAAGCCGGT GCTGCCAGCA 
GCCATGCCCA GCTCCATGGG AGGTGGAGGT GGAGGTAGCC CCAGCCCTGT GGAGCTTCGG 
GGGGCTCTGG CAGGCCCCAT GGACCCCGCG CTTCGGGAGC AGCAACTGCA GCAAGAGCTC 
CTGGTGCTCA AGCAGCAGCA GCAGCTGCAA AAGCAGCTCC TGTTTGCCGA GTTTCAGAAG 
CAGCACGACC ACCTGACGCG GCAGCATGAA GTCCAGCTGC AGAAGCACCT CAAGCAGCAG 
CAGGAGATGC TGGCGGCTAA GAGGCAGCAG GAGCTGGAGC AGCAGCGGCA GCGCGAGCAG 
CAGCGGCAAG AGGAGCTAGA GAAACAGCGG CTGGAGCAGC AGCTGCTTAT TCTACGAAAC 
AAGGAGAAGA GCAAAGAGAG TGCCATCGCC AGCACCGAGG TAAAGCTGAG GCTCCAGGAA 
TTCCTGTTGT CCAAGTCAAA GGAGCCCACA CCAGGCGGCC TCAACCATTC CCTCCCACAG 
CACCCCAAAT GCTGGGGAGC CCATCATGCT TCTTTGGACC AGAGTTCCCC TCCCCAGAGC 
GGCCCTCCTG GGACGCCTCC CTCCTACAAA TTGCCTTTGC TTGGGCCCTA TGACAGCCGT 
GATGACTTTC CCCTCCGTAA AACGGCCTCG GAACCCAACT TAAAAGTACG TTCAAGGCTA 
AAACAGAAGG TAGCTGAGAG AAGAAGCAGT CCCCTCCTGC GTCGAAAGGA TGGCACTGTT 
ATTAGTACTT TTAAGAAGAG AGCAGTCGAG ATCACAGGCA CAGGGCCTGG GGTGTCGTCC 
GTGTGTAACA GTGCGCCTGG CTCTGGCCCC AGCTCTCCCA ACAGTTCCCA CAGCACCATC 
GCTGAGAACG GCTTTACTGG CTCAGTCCCC AACATCCCCA CTGAGATGCT CCCCCAGCAC 
CGGGCCCTCC CTCTGGACAG TTCCCCAAAC CAGTTCAGCC TCTACACGTC TCCTTCTCTG 
CCTAACATCT CCCTAGGGCT GCAGGCCACT GTCACTGTTA CCAACTCGCA CCTCACCGCC 
TCCCCGAAGC TGTCGACACA GCAGGAGGCT GAGAGGCAGG CCCTTCAGTC CCTGCGGCAG 
GGCAGCACAC TGACCGGCAA GTTCATGAGC ACATCCTCCA TCCCTGGCTG CCTGCTGGGA 
GTGGCCCTGG AGGGCGACAC GAGCCCCCAT GGGCACGCTT CCCTGCTGCA GCACGTTTTG 
CTGCTGGAGC AGGCCCGGCA ACAGAGCACG CTCATAGCGG TGCCACTCCA TGGGCAGTCC 
CCACTGGTGA CGGGTGAACG TGTGGCCACC AGCATGAGGA CAGTGGGCAA GCTCCCAAGG 
CACCGACCTC TGAGCCGTAC TCAGTCCTCG CCCCTGCCGC AGAGTCCCCA GGCCCTGCAG 
CAGCTGGTTA TGCAGCAGCA GCACCAGCAG TTCCTAGAGA AACAGAAGCA GCAGCAGATG 
CAGCTGGGCA AGATCCTTAC CAAAACTGGG GAGCTGTCAA GGCAGCCCAC CACCCACCCT 
GAAGAGACAG AGGAGGAGCT GACGGAACAG CAGGAGGCCT TGCTGGGGGA GGGGGCCCTG 
ACCATGCCCC GGGAAGGTTC TACAGAGAGC GAGAGCACCC AGGAAGATCT AGAAGAGGAA 
GAGGATGAGG AGGAGGACGA GGAGGACTGC ATTCAGGTCA AGGATGAGGA TGGCGAGAGT 
GGTCCTGATG AGGGCGCAGA CTTGGAGGAG TCCAGTGCTG GTTACAAAAA GTTGTTCGCA 
GATGCCCAGC AGTTACAGCC CCTCCAGGTA TACCAGGCAC CCCTCAGCCT GGCCACTGTG 
CCTCATCAGG CCCTGGGCCG CACCCAGTCC TCACCTGCTG CTCCTGGGAG CATGAAGAGC 
CCCACAGACC ACCCCACTGT GGTGAAGCAC CTCTTCACCA CAGGTGTGGT CTATGACACG 
TTCATGCTGA AGCATCAGTG TATGTGCGGA AACACACATG TGCACCCAGA GCACGCCGGC 
CGCATCCAGA GCATCTGGTC CCGGCTGCAG GAAACTGGTC TGCTCAGCAA GTGTGAGCGG 
ATCCGGGGTC GTAAAGCCAC ACTGGATGAA ATCCAGACCG TGCACTCTGA GTACCACACC 
CTGCTCTATG GGACCAGTCC CCTTAACCGG CAGAAGCTGG ACAGTAAGAA GCTGCTTGGC 
CCCATCAGCC AGAAGATGTA CGCCATGCTG CCTTGTGGGG GCATTGGGGT GGACAGTGAC 
ACTGTGTGGA ATGAGATGCA CTCCTCTAGT GCCGTGCGAA TGGCAGTGGG CTGCCTGGTG 
GAGCTGGCCT TCAAGGTGGC TGCAGGAGAG CTCAAGAATG GATTTGCCAT CATCCGACCC 
CCAGGACATC ATGCTGAGGA GTCCACAGCC ATGGGATTCT GCTTCTTCAA CTCCGTAGCC 
ATCACAGCTA AACTCCTGCA GCAGAAGCTG AGCGTGGGCA AGGTCCTCAT CGTGGACTGG 
GACATTCACC ACGGCAATGG CACCCAGCAA GCATTTTACG ATGACCCCTC CGTGCTCTAC 
ATCTCTTTGC ATCGCTACGA CAATGGGAAC TTCTTTCCAG GCTCCGGGGC TCCTGAAGAG 
GTTGGTGGAG GGCCAGGTGT GGGGTACAAC GTAAATGTGG CGTGGACAGG AGGTGTGGAT 
CCCCCCATTG GAGATGTGGA ATACCTGACA GCCTTCAGGA CAGTAGTGAT GCCCATTGCC 
CACGAGTTCT CACCCGACGT CGTTCTAGTC TCCGCTGGGT TTGATGCTGT TGAAGGACAT 
CTGTCTCCAC TGGGTGGCTA TTCTGTCACC GCCAGATGTT TTGGCCACTT GACCAGGCAG 
CTCATGACAC TGGCAGGGGG CCGGGTGGTG CTGGCCCTGG AGGGAGGTCA TGACTTGACC 
GCCATCTGTG ATGCTTCTGA GGCCTGTGTC TCGGCTCTGC TCAGCGTGGA GCTGCAGCCC 
TTGGATGAAG CAGTCTTGCA GCAAAAGCCC AGCGTCAATG CAGTTGCCAC ACTAGAGAAA 
GTCATCGAGA TCCAGAGCAA ACACTGGAGC TGTGTACAGA GGTTTGCCAC TGGTCTGGGC 
TGCTCGCTGC GGGAGGCTCA GACGGGTGAG AAAGAGGAGG CCGAGACTGT GAGCGCCATG 
GCCCTGCTTT CCATGGGGGC TGAGCAGGCC CAGGCTGCTG CCACTCAAGA GCACAGCCCC 
CGGCCAGCCG AGGAGCCCAT GGAGCAGGAG CCTGCCCTGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_445902.1
CDS326..3667
Translation

Target ORF information:

RefSeq Version NM_053450.1
Organism Rattus norvegicus(Norway rat)
Definition Rattus norvegicus histone deacetylase 5 (Hdac5), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_053450.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
ATGAACTCTC CCAACGAGTC GGATGGCATG TCAGGCCGGG AACCATCCTT GGAAATCTTG 
CCACGGACTC CTCTGCACAG CATCCCTGTG GCAGTGGAGG TGAAGCCGGT GCTGCCAGCA 
GCCATGCCCA GCTCCATGGG AGGTGGAGGT GGAGGTAGCC CCAGCCCTGT GGAGCTTCGG 
GGGGCTCTGG CAGGCCCCAT GGACCCCGCG CTTCGGGAGC AGCAACTGCA GCAAGAGCTC 
CTGGTGCTCA AGCAGCAGCA GCAGCTGCAA AAGCAGCTCC TGTTTGCCGA GTTTCAGAAG 
CAGCACGACC ACCTGACGCG GCAGCATGAA GTCCAGCTGC AGAAGCACCT CAAGCAGCAG 
CAGGAGATGC TGGCGGCTAA GAGGCAGCAG GAGCTGGAGC AGCAGCGGCA GCGCGAGCAG 
CAGCGGCAAG AGGAGCTAGA GAAACAGCGG CTGGAGCAGC AGCTGCTTAT TCTACGAAAC 
AAGGAGAAGA GCAAAGAGAG TGCCATCGCC AGCACCGAGG TAAAGCTGAG GCTCCAGGAA 
TTCCTGTTGT CCAAGTCAAA GGAGCCCACA CCAGGCGGCC TCAACCATTC CCTCCCACAG 
CACCCCAAAT GCTGGGGAGC CCATCATGCT TCTTTGGACC AGAGTTCCCC TCCCCAGAGC 
GGCCCTCCTG GGACGCCTCC CTCCTACAAA TTGCCTTTGC TTGGGCCCTA TGACAGCCGT 
GATGACTTTC CCCTCCGTAA AACGGCCTCG GAACCCAACT TAAAAGTACG TTCAAGGCTA 
AAACAGAAGG TAGCTGAGAG AAGAAGCAGT CCCCTCCTGC GTCGAAAGGA TGGCACTGTT 
ATTAGTACTT TTAAGAAGAG AGCAGTCGAG ATCACAGGCA CAGGGCCTGG GGTGTCGTCC 
GTGTGTAACA GTGCGCCTGG CTCTGGCCCC AGCTCTCCCA ACAGTTCCCA CAGCACCATC 
GCTGAGAACG GCTTTACTGG CTCAGTCCCC AACATCCCCA CTGAGATGCT CCCCCAGCAC 
CGGGCCCTCC CTCTGGACAG TTCCCCAAAC CAGTTCAGCC TCTACACGTC TCCTTCTCTG 
CCTAACATCT CCCTAGGGCT GCAGGCCACT GTCACTGTTA CCAACTCGCA CCTCACCGCC 
TCCCCGAAGC TGTCGACACA GCAGGAGGCT GAGAGGCAGG CCCTTCAGTC CCTGCGGCAG 
GGCAGCACAC TGACCGGCAA GTTCATGAGC ACATCCTCCA TCCCTGGCTG CCTGCTGGGA 
GTGGCCCTGG AGGGCGACAC GAGCCCCCAT GGGCACGCTT CCCTGCTGCA GCACGTTTTG 
CTGCTGGAGC AGGCCCGGCA ACAGAGCACG CTCATAGCGG TGCCACTCCA TGGGCAGTCC 
CCACTGGTGA CGGGTGAACG TGTGGCCACC AGCATGAGGA CAGTGGGCAA GCTCCCAAGG 
CACCGACCTC TGAGCCGTAC TCAGTCCTCG CCCCTGCCGC AGAGTCCCCA GGCCCTGCAG 
CAGCTGGTTA TGCAGCAGCA GCACCAGCAG TTCCTAGAGA AACAGAAGCA GCAGCAGATG 
CAGCTGGGCA AGATCCTTAC CAAAACTGGG GAGCTGTCAA GGCAGCCCAC CACCCACCCT 
GAAGAGACAG AGGAGGAGCT GACGGAACAG CAGGAGGCCT TGCTGGGGGA GGGGGCCCTG 
ACCATGCCCC GGGAAGGTTC TACAGAGAGC GAGAGCACCC AGGAAGATCT AGAAGAGGAA 
GAGGATGAGG AGGAGGACGA GGAGGACTGC ATTCAGGTCA AGGATGAGGA TGGCGAGAGT 
GGTCCTGATG AGGGCGCAGA CTTGGAGGAG TCCAGTGCTG GTTACAAAAA GTTGTTCGCA 
GATGCCCAGC AGTTACAGCC CCTCCAGGTA TACCAGGCAC CCCTCAGCCT GGCCACTGTG 
CCTCATCAGG CCCTGGGCCG CACCCAGTCC TCACCTGCTG CTCCTGGGAG CATGAAGAGC 
CCCACAGACC ACCCCACTGT GGTGAAGCAC CTCTTCACCA CAGGTGTGGT CTATGACACG 
TTCATGCTGA AGCATCAGTG TATGTGCGGA AACACACATG TGCACCCAGA GCACGCCGGC 
CGCATCCAGA GCATCTGGTC CCGGCTGCAG GAAACTGGTC TGCTCAGCAA GTGTGAGCGG 
ATCCGGGGTC GTAAAGCCAC ACTGGATGAA ATCCAGACCG TGCACTCTGA GTACCACACC 
CTGCTCTATG GGACCAGTCC CCTTAACCGG CAGAAGCTGG ACAGTAAGAA GCTGCTTGGC 
CCCATCAGCC AGAAGATGTA CGCCATGCTG CCTTGTGGGG GCATTGGGGT GGACAGTGAC 
ACTGTGTGGA ATGAGATGCA CTCCTCTAGT GCCGTGCGAA TGGCAGTGGG CTGCCTGGTG 
GAGCTGGCCT TCAAGGTGGC TGCAGGAGAG CTCAAGAATG GATTTGCCAT CATCCGACCC 
CCAGGACATC ATGCTGAGGA GTCCACAGCC ATGGGATTCT GCTTCTTCAA CTCCGTAGCC 
ATCACAGCTA AACTCCTGCA GCAGAAGCTG AGCGTGGGCA AGGTCCTCAT CGTGGACTGG 
GACATTCACC ACGGCAATGG CACCCAGCAA GCATTTTACG ATGACCCCTC CGTGCTCTAC 
ATCTCTTTGC ATCGCTACGA CAATGGGAAC TTCTTTCCAG GCTCCGGGGC TCCTGAAGAG 
GTTGGTGGAG GGCCAGGTGT GGGGTACAAC GTAAATGTGG CGTGGACAGG AGGTGTGGAT 
CCCCCCATTG GAGATGTGGA ATACCTGACA GCCTTCAGGA CAGTAGTGAT GCCCATTGCC 
CACGAGTTCT CACCCGACGT CGTTCTAGTC TCCGCTGGGT TTGATGCTGT TGAAGGACAT 
CTGTCTCCAC TGGGTGGCTA TTCTGTCACC GCCAGATGTT TTGGCCACTT GACCAGGCAG 
CTCATGACAC TGGCAGGGGG CCGGGTGGTG CTGGCCCTGG AGGGAGGTCA TGACTTGACC 
GCCATCTGTG ATGCTTCTGA GGCCTGTGTC TCGGCTCTGC TCAGCGTGGA GCTGCAGCCC 
TTGGATGAAG CAGTCTTGCA GCAAAAGCCC AGCGTCAATG CAGTTGCCAC ACTAGAGAAA 
GTCATCGAGA TCCAGAGCAA ACACTGGAGC TGTGTACAGA GGTTTGCCAC TGGTCTGGGC 
TGCTCGCTGC GGGAGGCTCA GACGGGTGAG AAAGAGGAGG CCGAGACTGT GAGCGCCATG 
GCCCTGCTTT CCATGGGGGC TGAGCAGGCC CAGGCTGCTG CCACTCAAGA GCACAGCCCC 
CGGCCAGCCG AGGAGCCCAT GGAGCAGGAG CCTGCCCTGT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

HDAC5 and Its Target Gene, Npas4, Function in the Nucleus Accumbens to Regulate Cocaine-Conditioned Behaviors.
Neuron96(1)130-144.e6(2017 Sep)
Taniguchi M,Carreira MB,Cooper YA,Bobadilla AC,Heinsbroek JA,Koike N,Larson EB,Balmuth EA,Hughes BW,Penrod RD,Kumar J,Smith LN,Guzman D,Takahashi JS,Kim TK,Kalivas PW,Self DW,Lin Y,Cowan CW