GenScript Applies Gene Synthesis Knowhow to Synthetic Library Services
GenScript has added a synthetic library service to its already wide range of gene, peptide, protein, and antibody services. Synthetic gene libraries, in this case built using in vitro molecular optimization, are used to generate mutant proteins with improved or novel properties, to identify regulatory sequences, and to reveal structurally and functionally critical residues.
“Synthetic biology has been getting very big recently,” says Dr. James Wang, a GenScript representative. “We feel that GenScript is on top of this new trend. We provide synthetic genes, peptides, proteins, and now full synthetic libraries.”
Although the researchers’ final goal would be alternate versions of a specific protein, it is GenScript’s de novo gene synthesis department that figures heavily in this new project. A complete library has several versions of the same protein, usually with just one of its natural residues replaced with any of the other nineteen common amino acids. Working straight from modified genes is one of the more reliable means of generating such collections.
GenScript’s synthetic library services include site-directed mutagenesis libraries, sequential permutation scanning libraries, and randomized and degenerated libraries. Site-directed mutagenesis involves making changes to only one pre-selected residue, while sequential libraries involve changing residues in predictable order. GenScript provides randomized and degenerated libraries with a precise degree of controlled randomization.
GenScript Corporation provides high-quality gene synthesis, custom peptides, custom proteins, custom antibodies, kits, and reagents to life science researchers in industrial and academic settings throughout the world. GenScript Corporation is headquartered in Piscataway, New Jersey.
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