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For rapid development of high-yielding stable cell lines
3g/L average antibody titer
The Glutamine Synthetase gene expression is widely used for recombinant antibody and protein production in mammalian cell culture. Glutamine Synthetase gene expression relies on glutamine synthetase enzyme which synthesizes glutamine from glutamate and ammonium ions. Since many mammalian cells cannot make endogenous glutamine, transfection with a vector encoding Glutamine Synthetase enzyme ensures cell survival in culture. And for those cells that make endogenous glutamine, using the Glutamine Synthetase enzyme inhibitor, methionine sulfoximine (MSX), enables suppression of the endogenous glutamine while allowing use of the Glutamine Synthetase vector for recombinant expression. To learn more about the Glutamine Synthetase technology principle, click here.
GenScript's Glutamine Synthetase technology uses a proprietary vector with a strong promoter to drive recombinant gene expression and a relatively weaker promoter that drives the Glutamine Synthetase gene expression. The reliability of the Glutamine Synthetase gene expression will allow the rapid generation of high-producing cell lines. To see Glutamine Synthetase technology case studies, click here. For GenScript Glutamine Synthetase gene expression details, see below.
For details on GenScript's overall stable cell line service portfolio, click here.
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