GenScript offers a wide selection of GPCR stable cell lines. Proprietary codon optimization and vector design technologies enable GenScript to overcome low functional protein expression at the cell surface. All of the cell lines have been optimized for S/B ratio in calcium flux assays, FRET assays, or chemiluminescent assays.
Key features
- Gα15 expressing cells can be used directly for FLIPR analysis
- Stable cell lines for increased reliability and reproducibility
- Flexible functional readouts are available
Product list
|
Family
|
Receptor
|
Cell Line
|
Cat.No.
|
|---|---|---|---|
| 5-Hydroxytryptamine receptor | 5-HT1A/HTR1A | CHO-K1/5-HT1A/Gα15 | |
| 5-HT2A/HTR2A | CHO-K1/5-HT2A | ||
| 5-HT2B/HTR2B | CHO-K1/5-HT2B | ||
| 5-HT2C/HTR2C | CHO-K1/5-HT2C | ||
| 5-HT2C/HTR2C | HEK 293/5-HT2C | ||
| HTR4 | CHO-K1/5-HT4/Gα15 | ||
| Acetylcholine receptor (muscarinic) | M1/CHRM1 | CHO-K1/M1 | |
| M2/CHRM2 | CHO-K1/M2/Gα15 | ||
| M3/CHRM3 | CHO-K1/M3 | ||
| M4/CHRM4 | CHO-K1/M4/Gα15 | ||
| M5/CHRM5 | CHO-K1/M5 | ||
| Adenosine receptor | ADORA1 | CHO-K1/ADORA1/Gα15 | |
| ADORA1 | HEK293/ADORA1/Gα15 | ||
| ADORA2a | CHO-K1/ADORA2A/Gα15 | ||
| ADORA2a | CHO-K1/mouse ADORA2A | ||
| ADORA2B | CHO-K1/ADORA2B/Gα15 | ||
| ADORA3 | CHO-K1/ADORA3/Gα15 | ||
| Adrenoceptors | ADRA1B | CHO-K1/ADRA1B | |
| ADRA1D | CHO-K1/ADRA1D | ||
| ADRA2A | CHO-K1/ADRA2A/Gα15 | ||
| ADRA2B | CHO-K1/ADRA2B/Gqi5 | ||
| ADRA2C | CHO-K1/ADRA2C/Gα15 | ||
| ADRB1 | CHO-K1/ADRB1/Gα15 | ||
| ADRA1A | CHO-K1/ADRA1A | ||
| Angiotensin receptor | AT1 | HEK 293/AT1 | |
| AT1 | HEK293T/AT1 | ||
| Apelin receptor | AGTRL1 | CHO-K1/AGTRL1/Gα15 | |
| Bile acid receptor | GPBAR1 | CHO-K1/GPBAR1 |
|
Family
|
Receptor
|
Cell Line
|
Cat.No.
|
|---|---|---|---|
| Bombesin receptor | BB1 | CHO-K1/BB1 | |
| BB2/GRPR | CHO-K1/BB2 | ||
| BB3/BRS3 | CHO-K1/BB3 | ||
| Bradykinin receptor | B2 | CHO-K1/B2/Gα15 | |
| Calcitonin | AMY1 | CHO-K1/Gα15/AMY1 | |
| AMY2 | CHO-K1/Gα15/AMY2 | ||
| AMY3 | CHO-K1/Gα15/AMY3 | ||
| Calcitonin receptor | CALCR/CT | CHO-K1/CT/Gα15 | |
| Cannabinoid receptor | CNR1/CB1 | CHO-K1/CB1/Gα15 | |
| CB2 | CHO-K1/CB2 | ||
| Chemerin receptor | CMKLR1 | CHO-K1/CMKLR1/Gα15 | |
| Chemokine receptor | CCR1 | CHO-K1/CCR1/Gα15 | |
| CCR5 | CHO-K1/CCR5/Gα15 | ||
| CXCR1/IL8RA | CHO-K1/CXCR1/Gα15 | ||
| CXCR3 | CHO-K1/CXCR3/Gα15 | ||
| CXCR4 | CHO-K1/CXCR4/Gα15 | ||
| CXCR5/BLR1 | CHO-K1/CXCR5/Gα15 | ||
| Cholecystokinin receptor | CCKA/CCKAR | CHO-K1/CCKA/Gα15 | |
| CCKB/CCKBR | CHO-K1/CCKB | ||
| Class A orphan | GPR68/OGR1 | CHO-K1/GPR68/Gα15 | |
| MRGPRX2 | CHO-K1/MRGPRX2 | ||
| Complement peptide receptor | C5a/C5AR1 | CHO-K1/C5a/Gα15 | |
| Corticotropin releasing factor receptor | CRF1/CRHR1 | CHO-K1/CRF1/Gα15 | |
| CRF2 | CHO-K1/CRF2/Gα15 | ||
| Dopamine receptor | D2 | CHO-K1/D2/Gα15 | |
| D5 | CHO-K1/D5/Gα15 | ||
| D1/DRD1 | CHO-K1/D1 | ||
| D2(Short) | CHO-K1/D2s/Gα15 | ||
| Endothelin receptor | ETA/EDNRA | CHO-K1/EDNRA | |
| ETB/EDNRB | CHO-K1/EDNRB | ||
| Formylpeptide receptor | FPR1 | CHO-K1/FPR1/Gα15 | |
| Free fatty acid receptor | FFA2 | CHO-K1/FFA2/Gα15 | |
| GPR40/FFA1 | CHO-K1/FFA1/Gα15 |
|
Family
|
Receptor
|
Cell Line
|
Cat.No.
|
|---|---|---|---|
| Galanin receptor | GALR1 | CHO-K1/GALR1/Gα15 | |
| GALR2 | CHO-K1/GALR2 | ||
| Glucagon receptor | GHRHR | HEK293/GHRH/Gα15 | |
| GLP1R | CHO-K1/GLP1R/Gα15 | ||
| GLP2R | CHO-K1/GLP2R/Gα15 | ||
| GCGR | CHO-K1/GCGR/Gα15 | ||
| GCGR | HEK 293/GCGR/Gα15 | ||
| GIPR | CHO-K1/GIP/Gα15 | ||
| Gonadotropin releasing hormone receptor | GNRHR | CHO-K1/GNRHR/Gα15 | |
| Growth hormone releaseing peptides receptor | GHSR | CHO-K1/GHSR | |
| Histamine receptor | H1/HRH1 | HEK293/H1 | |
| H2/HRH2 | CHO-K1/H2/Gα15 | ||
| H3/HRH3 | CHO-K1/H3/Gα15 | ||
| H4/HRH4 | CHO-K1/H4/Gα15 | ||
| Hydroxycarboxlic acid receptor | GPR109A | CHO-K1/NIACR1/Gα15 | |
| Kisspeptin receptor | KiSS1/GPR54 | CHO-K1/KiSS1 | |
| Leukotriene receptor | FPRL1 | CHO-K1/FPRL1/Gα15 | |
| CysLT1 | CHO-K1/CysLT1/Gα15 | ||
| LTB4R | CHO-K1/LTB4/Gα15 | ||
| Lysophospholipid receptor | EDG4/LAP2 | RH7777/EDG4 | |
| Melanin concentrating hormone receptor | MCH1/GPR24 | HEK293/MCH1 | |
| MCH2/GPR145 | CHO-K1/MCH2 | ||
| Melanocortin receptor | MC2 | CHO-K1/MC2/Gα15 | |
| MC3 | CHO-K1/MC3/Gα15 | ||
| MC4 | CHO-K1/MC4/Gα15 | ||
| MC5 | CHO-K1/MC5/Gα15 | ||
| Melatonin receptor | MTNR1A | CHO-K1/MT1/Gα15 | |
| MT2/MTNR1B | CHO-K1/MT2/Gα15 | ||
| Metabropic glutamate receptor | mGlu2/GRM2 | CHO-K1/GRM2/Gα15 | |
| Motilin receptor | MTLR/MLNR | CHO-K1/MTLR/Gα15 |
|
Family
|
Receptor
|
Cell Line
|
Cat.No.
|
|---|---|---|---|
| Neuromedin receptor | NMU2 | HEK293T/NMU2 | |
| NMU1/GPR66 | CHO-K1/NMU1 | ||
| Neuropeptide S receptor | NPS1b | CHO-K1/NPS1b/Gα15 | |
| NPSR1 | CHO-K1/NPS1a/Gα15 | ||
| Neuropeptide Y receptor | NPY2 | CHO-K1/NPY2/Gqi5 | |
| NPY4R | CHO-K1/NPY4/Gα15 | ||
| Neurotensin receptor | NTS1/NT1 | CHO-K1/NTS1 | |
| Opioid & opioid-like receptor | OPRD1 | CHO-K1/OPRD1/Gα15 | |
| OPRK1 | CHO-K1/OPRK1/Gα15 | ||
| OPRM1 | CHO-K1/OPRM1/Gα15 | ||
| OPRL1 | CHO-K1/OPRL1/Gα15 | ||
| Orexin receptor | OX1 | CHO-K1/OX1 | |
| OX2 | CHO-K1/OX2 | ||
| P2Y receptor | P2Y1 | 1321N1/P2Y1 | |
| P2Y2 | 1321N1/P2Y2 | ||
| P2Y4 | 1321N1/P2Y4 | ||
| P2Y6 | 1321N1/P2Y6 | ||
| P2Y11 | 1321N1/P2Y11 | ||
| P2Y12 | 1321N1/P2Y12/Gα15 | ||
| Parathyroid hormone receptor | PTH1/PTHR1 | CHO-K1/PTH1/Gα15 | |
| Peptide P518 receptor | QRFP/GPR103 | CHO-K1/GPR103/Gα15 | |
| Platelet activating factor receptor | PAFR/PTAFR | CHO-K1/PTAFR | |
| Prolactin releasing peptide receptor | PRLHR | CHO-K1/PRLHR | |
| Prostanoid receptor | DP2 | CHO-K1/DP2/Gα15 | |
| EP1/PTGER1 | HEK293/EP1 | ||
| EP2/PTGER2 | CHO-K1/EP2/Gα15 | ||
| FP/PTGFR | HEK293/FP/Gα15 | ||
| IP1/PTGIR | CHO-K1/IP1/Gα15 | ||
| TP/TBXA2R | HEK293/TP | ||
| PTGDR/DP1 | CHO-K1/DP1/Gα15 | ||
| Proteinase-activated receptor | PAR2 | CHO-K1/PAR2/Gα15 | |
| PAR4/F2RL3 | CHO-K1/PAR4 |
|
Family
|
Receptor
|
Cell Line
|
Cat.No.
|
|---|---|---|---|
| Somatostatin receptor | SST1 | CHO-K1/SST1/Gqi5 | |
| SST2/SSTR2 | CHO-K1/SST2/Gα15 | ||
| SST3 | CHO-K1/SST3/Gα15 | ||
| SST4/SSTR4 | CHO-K1/SST4/Gα15 | ||
| SST5/SSTR5 | CHO-K1/SST5/Gα15 | ||
| Tachykinin receptor | NK1/TACR1 | CHO-K1/NK1 | |
| NK2/TACR2 | CHO-K1/NK2 | ||
| NK3/TACR3 | CHO-K1/NK3 | ||
| Thyrtropin releasing hormone receptor | TRH1/TRHR | CHO-K1/TRH1 | |
| Urotensin receptor | UTR2 | CHO-K1/UT2/Gα15 | |
| Vasopressin and oxytocin receptor | OT/OXTR | CHO-K1/OXTR | |
| V1B | CHO-K1/V1B | ||
| V2 | CHO-K1/V2/Gα15 | ||
| VIP and PACAP receptor | PAC1 | CHO-K1/PAC1/Gα15 | |
| VPAC2 | CHO-K1/VPAC2/Gα15 | ||
| VPAC1/VIP1 | CHO-K1/VPAC1/Gα15 | ||
| Control | \ | HEK293/Gα15 | |
| \ | CHO-K1/Gα15 | M00257 | |
| \ | CHO-K1/Gqi577 |
