Regulating Cas Proteins: A Chemical Toolbox Aiding Genome Editing

Off-target effects remain a major concern in CRISPR-mediated immunotherapies. Read on and learn how a chemical toolbox can be developed in an effort to overcome this problem.

Sep 16, 2021

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Fight the Pandemic: Super Antibodies Coming to the Rescue

The development of numerous vaccines against SARS-CoV-2 worldwide within one year of the pandemic is unprecedented and undoubtedly a huge accomplishment in human history.

Aug 18, 2021

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Promoting Anti-cancer Immune Responses Using Lethally Irradiated Tumor Cells

The study reveals the capacity of lymphangiogenic vaccines to promote a potent anti-cancer T cell immunity, and suggests a new protective and therapeutic approach to fight solid tumors.

Jul 22, 2021

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Curbing Anti-drug Antibody Enthusiasm Through CAR- and TRuC-redirected Regulatory T Cells

Rana, Jyoti, et al. "CAR and TRuC redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII." Molecular Therapy (2021).

Jun 09, 2021

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Unraveling Potential Hosts of SARS-CoV-2 with ACE2 Orthologs

Liu, Yinghui, et al. "Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2." Proceedings of the National Academy of Sciences 118.12 (2021).

May 06, 2021

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Production of Novel Monoclonal Antibodies Against the SERINC5 HIV-1 Restriction Factor

Molnar, Sebastian, et al. "Novel monoclonal antibodies to the SERINC5 HIV-1 restriction factor detect endogenous and virion-associated SERINC5." MAbs. Vol. 12. No. 1. Taylor & Francis, 2020.

Mar 23, 2021

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Base Editor Screens, a New Approach for Readily and Scalably Functionalizing Genetic Variants

Hanna, Ruth E., et al. "Massively parallel assessment of human variants with base editor screens." Cell 184.4 (2021): 1064-1080.

Mar 23, 2021

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