- Research Digest
21 Results
Improving CAR-T Therapy with CRISPR
An innovative type of non-viral, PD1-integrated CAR-T cells was developed and showed superior ability to safely fight tumor cells in patients with non-Hodgkin lymphoma in a phase I clinical trial.
11-28-2022Read More »
Improving Engineered T Cells by CRISPRing RASA2 Expression
Learn how the Alexander Marson lab at Gladstone-UCSF has identified a new intrinsic molecular checkpoint in T cells involved in modulating antigen sensitivity, cytotoxicity, and persistence.
10-25-2022Read More »
Individualized mRNA Neoantigen Vaccine Fights against Solid Tumors
An individualized mRNA-based vaccine induces strong, persistent, and functional tumor-specific T cell responses in patients with advanced metastatic solid tumors.
09-20-2022Read More »
Newly Developed Biosensor Combines HER2 Affibody and Marine Luciferase
Learn about a newly developed optical biosensor that takes advantage of the small size and specificity of affibodies and the high bioluminescent activity of a new luciferase from Metridia lucens copepod (MlLuc).
08-29-2022Read More »
Improved Adenine Base Editor Minimizes Undesired Edits for Gene Therapy
A newly developed next-generation adenine base editor may improve the safety of human gene therapy.
08-21-2022Read More »
Confronting the Challenges of Solid Tumors with Antigen Spreading
Learn how pre-existent immunity against non-tumor targets may be leveraged to drive immune cells towards the tumor microenvironment resulting in antigen spreading and reduced tumor growth.
08-16-2022Read More »
Achieving Efficient Therapeutic Genome Editing in Mammalian Cells with Cas12i
Researchers from Arbor Biotechnologies have developed a versatile, specific, and high-efficiency genome-editing platform and showed the therapeutic potential of Cas12i in mammalian cells for the first time.
07-22-2022Read More »
Lighting the Way to Antibody Drugs against Human Metapneumovirus
From human memory B cells, researchers at Merck & Co. have recently isolated over a hundred monoclonal antibodies that specifically target human metapneumovirus, a common cause of acute lower respiratory infection in children.
06-20-2022Read More »
