CTLA4 or CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152 (cluster of differentiation 152), is a protein receptor that functions as an immune checkpoint and downregulates immune responses. CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.
The CTLA-4 protein is encoded by the Ctla4 gene in mice and the CTLA4 gene in humans.
ALPS5; CD; CD152; CELIAC3; GRD4; GSE; IDDM12
|Freeze Medium||95% complete growth medium, 5% (V/V) DMSO (Cat. #D2650, Sigma)|
|Culture Medium||F-12K (Kaighn’s), 10% FBS, 8 μg/ml Puromycin (Cat. #A11138-03, Gibco)|
|Storage||Liquid nitrogen immediately upon receiving|
|Binding assay or use as immunogen.|
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