|Description||V-domain Ig suppressor of T cell activation (VISTA) is a potent negative regulator of T-cell function that is expressed on hematopoietic cells. VISTA levels are heightened within the tumor microenvironment, in which its blockade can enhance antitumor immune responses in mice. In humans, blockade of the related programmed cell death 1 (PD-1) pathway has shown great potential in clinical immunotherapy trials. Here, we report the structure of human VISTA and examine its function in lymphocyte negative regulation in cancer.|
|Culture Medium||F12K, 10% FBS, 600 μg/ml G418|
|Freeze Medium||95% complete growth medium, 5% DMSO|
|Storage||Liquid nitrogen immediately upon receiving|
|Binding assay or use as immunogen
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