Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. The formation of the PD-1 receptor / PD-L1 or B7.1 receptor /PD-L1 ligand complex transmits an inhibitory signal which reduces the proliferation of these CD8+ T cells at the lymph nodes. PD-1 is also able to control the accumulation of foreign antigen specific T cells in the lymph nodes through apoptosis, which is further mediated by a lower regulation of the gene Bcl-2.
CD274 ; B7-H; B7H1; PDCD1L1; PDCD1LG1; PDL1
|Applications||Binding assay or use as immunogen|
|Storage||Liquid nitrogen immediately upon receiving|
|Freeze Medium||95% complete growth medium, 5% DMSO|
|Culture Medium||DMEM, 10% FBS, 400 μg/ml G418|
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