Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein that in humans is encoded by the PDCD1 gene.PD-1, functioning as an immune checkpoint, plays an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells).
PDCD1 ; CD279; PD-1; SLEB2; hPD-1; hPD-l; hSLE1
|Freeze Medium||95% complete growth medium, 5% DMSO|
|Culture Medium||F12K, 10% FBS, 8μg/ml Puromycin|
|Storage||Liquid nitrogen immediately upon receipt|
|Binding assay or use as immunogen|
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