Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. The formation of PD-1 receptor / PD-L1 or B7.1 receptor /PD-L1 ligand complex transmits an inhibitory signal which reduces the proliferation of these CD8+ T cells at the lymph nodes. Supplementary to that PD-1 is also able to control the accumulation of foreign antigen specific T cells in the lymph nodes through apoptosis which is further mediated by a lower regulation of the gene Bcl-2.
CD274, B7-H, B7H1, PDCD1L1, PDCD1LG1, PDL1, CD274 molecule, Programmed cell death 1 ligand 1
|Freeze Medium||95% complete growth medium, 5% DMSO|
|Culture Medium||F12K, 10% FBS, 6 μg/ml Puromycin|
|Storage||Liquid nitrogen immediately upon receipt|
|Binding assay or use as immunogen|
For more documents, please visit "Technical Support".