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Send Us Your mRNA Samples for Quality Control Analysis

Ensure the quality of your mRNA by leveraging GenScript’s mRNA manufacturing expertise to perform reliable QC analysis on your IVT mRNA samples.

Simply fill out the form to request a quote for your preferred QC tests and send us your mRNA sample. Analysis typically takes 1-3 weeks depending on the specific tests (see table below).

IVT RNA Services

mRNA QC Service Introduction

Option mRNA QC Test TAT, days Amount Required Method
1 PolyA Tail Length Assay 7 300pmol RNase digestion and purification to recover the polyA tail fragment, followed by polyA tail length analysis by small RNA bio-analyzer kit assay or LC-MS.
2 Capping Efficiency Assay 14-21 300pmol RNase digestion to isolate a short oligo from the 5’ end of the mRNA sample to be analyzed by LC-MS to calculate the capping efficiency.
3 dsRNA Residue Assay 10 40ug Slot-blot assay using a dsRNA-specific antibody to test for dsRNA residues in mRNA sample.
4 RNA Capillary Electrophoresis 5 10ug Bioanalyzer assay to test RNA length and purity.
5 Total Protein Residue Assay 7 200ug Nano-orange assay to test the residual protein amount in mRNA sample.
6 Plasmid DNA Residue Assay 14 15ug q-PCR assay to test the residual plasmid DNA residue amount in mRNA sample.
7 Quantitative Endotoxin Assay 5 15uL GenScript ToxinSensor™ Chromogenic LAL Endotoxin Assay to test endotoxin level in mRNA sample.
8 BioBurden Assay 14 250uL TSA plate to recover a broad range of microorganisms such as aerobic and anaerobic bacteria from liquid.
9 Sanger Sequencing 7 5ug RT-PCR and sanger sequencing, alignment with target sequence for data analysis. 2-4X coverage.
10 NGS 14 5ug Illumina platform with 1G data amount, 10,000X depth.
11 RNA Aggregation Assay 7 30ug SEC-HPLC method
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Additional mRNA Offerings

Custom mRNA
Custom mRNA Synthesis

High-quality custom mRNA production via our proprietary IVT RNA manufacturing workflow.

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Catalog IVT RNA
Catalog IVT RNA

Our off-the-shelf mRNA is optimized with 5’ cap and polyA tails that is ready to use for your research needs

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Lipid Nanoparticle Packaging
Lipid Nanoparticle Packaging

LNP Packaging

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Circular
Circular RNA

Circular RNA offers improved stability and longer expression duration.

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mRNA QC Services

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PHONE

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