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Expediting Omicron Research

The new SARS-CoV-2 variant Omicron (B.1.1.529) was first identified in South Africa at the end of November 2021 and classified as a variant of concern (VOC). Omicron has led to increased COVID-19 cases in South Africa and has been detected in Australia, Germany, the Netherlands, Canada, and many other countries. Following the quick rise of the Delta variant, Omicron’s emergence is concerning scientists due to the impressive number of mutations, many of which are found within the Spike protein (~ 30 mutations). The increased number of mutations in Spike’s receptor-binding domain (RBD) may affect how this variant interacts with the entry receptor ACE2 and antibodies. Much remains to be learned about Omicron, but preliminary findings suggest an increased risk of reinfection with this VOC.

Spike protein mutations in the new SARS-CoV-2 variant of concern, Omicron.
Retrieved from COG-UK/Mutation Explorer. Creative Commons Attribution- 4.0 International License.

Mutations in the SARS-CoV-2 variant Omicron. Retrieved from SARS-CoV-2 variant genome viewer, Stanford University Coronavirus Antiviral & Resistance Database.

S Gene Plasmids for SARS-CoV-2 Omicron Variant (B.1.1.529)

Cat. No. Plasmid Name Description Price Timeline Ordering
MC_0101271 SARS-CoV-2 Omicron Strain S gene original_pUC57 SARS-CoV-2 Omicron Strain $420 Next-day Submit Request
MC_0101272 SARS-CoV-2 Omicron Strain S gene Human codon_pUC57 SARS-CoV-2 Omicron Strain $420 Next-day Submit Request
MC_0101273 SARS-CoV-2 Omicron Strain S gene original_pcDNA3.1(+) SARS-CoV-2 Omicron Strain $420 Next-day Submit Request
MC_0101274 SARS-CoV-2 Omicron Strain S gene Human codon_pcDNA3.1(+) SARS-CoV-2 Omicron Strain $420 Next-day Submit Request

Please click this page for more S protein plasmids.

Peptide Library for SARS-CoV-2 Omicron Variant (B.1.1.529)

All peptide libraries are designed by overlapping peptide library tool.

Protein Name Source Number of Peptide Purity Sequence Timeline Ordering
SARS-CoV-2 Spike Glycoprotein (B.1.1.529) SARSr-CoV (Severe Acute Respiratory Syndrome-related coronavirus 2) Spike glycoprotein (B.1.1.529) 315 peptides (15mers with 11 aa overlap) Crude Datasheet In stock RP30121
≥70% to ≥98% PDF 3 weeks Submit Request
or email us at [email protected]

Recombinant Proteins for SARS-CoV-2 Omicron Variant (B.1.1.529)

Cat. No. Protein Name Mutation Site Tag Ordering
Z03729 S1 Protein A67V, del69-70, T95I, G142D, del143-145, del211, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H C-terminal His Order Now
Z03728 S-RBD G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H C-terminal His Order Now
Z03730 RBD-HRP G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H C-terminal His Order Now
Z03731 N Protein G204R, R203K C-terminal His Order Now

For other variants, tags, or expression system, please click here for off-the-shelf products or click here for custom services.

Antibodies for SARS-CoV-2 Omicron Variant (B.1.1.529)

Nucleocapsid antibody

Cat. No. Clone Wild-type NP binding Delta NP binding Omicron NP binding Antibody Pair LFA Assay
A02135 N338 +++++ +++++ +++++ A02135-A02136
A02135-A02138
+++++
A02136 N34 +++++ ++++++ ++++++ A02135-A02136 ++++++
A02137 N66 ++++++ +++++ ++++++ Not Test Not Test
A02138 Cocktail +++++ +++++ ++++++ A02135-A02138 ++++

Neutralizing antibody standard

Cat. No. Description Recommend Applications
A02161 SARS-CoV-2 (Omicron) Neutralizing Antibody Standard Calibrate quantitative assay of SARS-CoV-2 neutralizing antibody (sVNT, PRNT, pVNT) for the Omicron variant

S-Envelope Pseudovirus for SARS-CoV-2 Omicron Variant (B.1.1.529)

Amount Titer Timeline Ordering
0.1mL, 0.5mL, 1mL, and others 108 IFU/ml 4-6 weeks
(including shipping)
On-demand only
Email us at [email protected]

Pseudovirus Neutralization Assay Kit for SARS-CoV-2 Omicron Variant (B.1.1.529)

Cat. No. Product Name Mutation Site Components Timeline Ordering
SC2087-027 SARS-CoV-2 CoV-2 Omicron Variant (B.1.1.529) Pseudovirus Neutralization Assay Kit_Luc Reporter H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F
  • Pseudovirus: 1 vial of Luc reporter (96T)
  • Target cell: 2 vials for a 96-well plate
    2 × 106 cells/vial (proliferation-incompetent)
  • Positive neutralizing antibody for 1 dose curve
4-6 Weeks Email us at [email protected]

ELISA Reagents for SARS-CoV-2 Neutralizing Antibody Detection

Cat. No. Product Name Description Variant Research Use Timeline Ordering
L00847-A SARS-CoV-2 Surrogate Neutralizing Test (sVNT) Kit

Visit this page to learn more about this kit.
A blocking ELISA that mimics the gold standard cell-based assay, PRNT, to qualitatively and semi-quantitatively detect functional neutralizing antibodies against SARS-CoV-2. Use GenScript’s Variant of Concern (VOC) RBD-HRP products in place of the WT-based RBD-HRP kit component. In stock Submit Request