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Protein Expression System Engineering
- Engineering of Hsp104, a protein disaggregase from yeast, to counter the misfolding of proteins that aggregate in ALS and Parkinson's disease;
- How different missense mutations, both conservative and non-conservative, can potentiate Hsp104;
- Uncover variants with improved properties and learn about the mechanism of Hsp104 potentiation by screening large libraries of Hsp104 variants that comprehensively cover the sequence space.