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Protein orgin:

Example: P53_HUMAN, P04637 (UniProt Accession Number), NP_000537, P53 (protein name), Species Summary

If you enter a valid Uniprot ID, UniProt accession number or RefSeq protein ID, the system will not consider the species and reviewed settings of your query. The choices of species and reviewed settings are considered only if you query protein names, protein description or gene names.


Antigenicity Information of Integrin beta-3

Protein name and sequence of (Integrin beta-3)

Protein Names
Recommended name:

Integrin beta-3
Protein IDs
(Accession numbers)
UniProtKB: P05106
NCBI RefSeq: NP_000203.2
NM_000212.2
Organism
Latin Name/
(Common Name) :		 Homo sapiens (Human).
Gene Names ITGB3
Protein Sequence 
    SEQUENCE   788 AA;  87058 MW;  F246623608E05F9E CRC64;
MRARPRPRPL WATVLALGAL AGVGVGGPNI CTTRGVSSCQ QCLAVSPMCA WCSDEALPLG
SPRCDLKENL LKDNCAPESI EFPVSEARVL EDRPLSDKGS GDSSQVTQVS PQRIALRLRP
DDSKNFSIQV RQVEDYPVDI YYLMDLSYSM KDDLWSIQNL GTKLATQMRK LTSNLRIGFG
AFVDKPVSPY MYISPPEALE NPCYDMKTTC LPMFGYKHVL TLTDQVTRFN EEVKKQSVSR
NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVQPNDGQCH
VGSDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VNLYQNYSEL IPGTTVGVLS
MDSSNVLQLI VDAYGKIRSK VELEVRDLPE ELSLSFNATC LNNEVIPGLK SCMGLKIGDT
VSFSIEAKVR GCPQEKEKSF TIKPVGFKDS LIVQVTFDCD CACQAQAEPN SHRCNNGNGT
FECGVCRCGP GWLGSQCECS EEDYRPSQQD ECSPREGQPV CSQRGECLCG QCVCHSSDFG
KITGKYCECD DFSCVRYKGE MCSGHGQCSC GDCLCDSDWT GYYCNCTTRT DTCMSSNGLL
CSGRGKCECG SCVCIQPGSY GDTCEKCPTC PDACTFKKEC VECKKFDRGA LHDENTCNRY
CRDEIESVKE LKDTGKDAVN CTYKNEDDCV VRFQYYEDSS GKSILYVVEE PECPKGPDIL
VVLLSVMGAI LLIGLAALLI WKLLITIHDR KEFAKFEEER ARAKWDTANN PLYKEATSTF
TNITYRGT
General annotation
Involvement in disease Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]
also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. It is an autosomal recessive disorder characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb/beta-3 complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the glycoprotein IIb/beta-3 complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT 'variants' have normal or near normal (60-100%) expression of dysfunctional receptors.

Suggested Antigen peptide sequence of ( Integrin beta-3) in rabbit

     

What we offer for Integrin beta-3

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