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Protein orgin:

Example: P53_HUMAN, P04637 (UniProt Accession Number), NP_000537, P53 (protein name), Species Summary

If you enter a valid Uniprot ID, UniProt accession number or RefSeq protein ID, the system will not consider the species and reviewed settings of your query. The choices of species and reviewed settings are considered only if you query protein names, protein description or gene names.


Antigenicity Information of Myocilin

Protein name and sequence of (Myocilin)

Protein Names
Recommended name:

Myocilin
Protein IDs
(Accession numbers)
UniProtKB: Q99972
NCBI RefSeq: NP_000252.1
NM_000261.1
Organism
Latin Name/
(Common Name) :		 Homo sapiens (Human).
Gene Names MYOC
Protein Sequence 
    SEQUENCE   504 AA;  56972 MW;  9588C04F1D227623 CRC64;
MRFFCARCCS FGPEMPAVQL LLLACLVWDV GARTAQLRKA NDQSGRCQYT FSVASPNESS
CPEQSQAMSV IHNLQRDSST QRLDLEATKA RLSSLESLLH QLTLDQAARP QETQEGLQRE
LGTLRRERDQ LETQTRELET AYSNLLRDKS VLEEEKKRLR QENENLARRL ESSSQEVARL
RRGQCPQTRD TARAVPPGSR EVSTWNLDTL AFQELKSELT EVPASRILKE SPSGYLRSGE
GDTGCGELVW VGEPLTLRTA ETITGKYGVW MRDPKPTYPY TQETTWRIDT VGTDVRQVFE
YDLISQFMQG YPSKVHILPR PLESTGAVVY SGSLYFQGAE SRTVIRYELN TETVKAEKEI
PGAGYHGQFP YSWGGYTDID LAVDEAGLWV IYSTDEAKGA IVLSKLNPEN LELEQTWETN
IRKQSVANAF IICGTLYTVS SYTSADATVN FAYDTGTGIS KTLTIPFKNR YKYSSMIDYN
PLEKKLFAWD NLNMVTYDIK LSKM
General annotation
Involvement in disease Defects in MYOC are the cause of primary open angle glaucoma type 1A (GLC1A) [MIM:137750]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.
Defects in MYOC may also contribute to primary congenital glaucoma type 3A (GLC3A) [MIM:231300]. Defects in MYOC may contribute to this phenotype via digenic inheritance. GLC3A is an autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early choldhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.

Suggested Antigen peptide sequence of ( Myocilin) in rabbit

     

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