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Catalog Products » Other Products » Catalog Peptides » Beta Amyloid Peptides » β-Amyloid (1-42), human

β-Amyloid (1-42), human

Description This peptide is well suited to the quantitative determination of A 42 peptide. Alzheimer’s disease (AD) is characterized by the presence of extracellular plaques and intracellular neurofibrillary tangles (NFTs) in the brain. The major protein component of these plaques is beta amyloid peptide (A), a 40- to 43- amino-acid peptide cleaved from amyloid precursor protein by secretase (BACE) and a putative (gamma) secretase. Increased release of the ‘longer forms’ of A peptide, A 42 and A 43, which have a greater tendency to aggregate than A 40, occurs in individuals expressing certain genetic mutations, expressing certain ApoE alleles or may other, still undiscovered factors.
Cas No 107761-42-2
Sequence
{ASP}{ALA}{GLU}{PHE}{ARG}{HIS}{ASP}{SER}{GLY}{TYR}{GLU}{VAL}
{HIS}{HIS}{GLN}{LYS}{LEU}{VAL}{PHE}{PHE}{ALA}{GLU}{ASP}{VAL}
{GLY}{SER} {ASN}{LYS}{GLY}{ALA}{ILE}{ILE}{GLY}{LEU}{MET}{VAL
}{GLY}{GLY}{VAL}{VAL}{ILE}{ALA}
Sequence Shortening DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Molecular Formula C203H311N55O60S1
Molecular Weight 4514.1

Purity > 95%
Solubility Soluble in water
Anaspec Cat No Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
Storage Store at -20°C
Note This product is a chemically-modified β-amyloid (1-42) precursor, which belongs to GenScript’s click peptides. The click peptides; are best described by the following key features:
1. Enhanced Stability—The O-acyl moiety within the click peptide is stable even under acidic pH.
2. Convenient and quick process—The click peptides can be easily converted to native peptide at pH 7.4 or above.
3. No by-product formation in the conversion process.
4. Superior quality—After the click, the aggregative property of the peptides is significantly minimized compared to its native format.

  • β-Amyloid (1-42), Human
  • β-Amyloid (1-42), Human

    β-amyloid (1-42) click peptide


Cat. No.
Product Name
Price
RP10034-1
β-Amyloid (42-1) - 1 mg
$475.00
RP10034-0.5
β-Amyloid (42-1) - 0.5 mg
$285.00
RP10016-0.5
β-Amyloid (1-40), rat - 0.5 mg
$157.00
RP10013-1
β-Amyloid (1-42), rat - 1 mg
$309.00
RP10013-0.5
β-Amyloid (1-42), rat - 0.5 mg
$176.00
RP10008-5
β-Amyloid (25-35) - 5 mg
$209.00
RP10008-1
β-Amyloid (25-35) - 1 mg
$52.00
RP10004-1
β-Amyloid (1-40) - 1 mg
$190.00
RP10004-0.5
β-Amyloid (1-40) - 0.5 mg
$114.00
RP10002-0.5
β-Amyloid (1-28) - 0.5 mg
$81.00
 

Ambroggio EE, et al. Surface behavior and lipid interaction of Alzheimer beta-amyloid peptide 1-42: a membrane-disrupting peptide. Biophys J. Apr 2005; 88(4): 2706-2713.

Mathew A., etc. Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease. PLoS One. 2012 Mar;7(3):e32616.

R Banerjee. etc. Effect of Curcumin on the metal ion induced fibrillization of Amyloid-β peptide. Spectrochim Acta A Mol Biomol Spectrosc. 2013 Sep;

Anila Mathew etc. Amyloid-Binding Aptamer Conjugated Curcumin-PLGA Nanoparticle for Potential Use in Alzheimer’s Disease. BioNanoScience. 2012 Jun; 2 (2); 83-93.

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Cat. No. RP10017
Size
Price
0.5 mg $119.00
1 mg $214.00