Neuropeptide F (NPF)

Protein-tyrosine phosphorylation is a universal mechanism employed for the regulation of cellular processes such as proliferation, differentiation, motility, cell-cell interactions, metabolism, gene transcription, and the immune response. Using synthetic pTyr-containing peptides that correspond to natural phosphorylation sites in proteins, several groups have demonstrated that PTPases display a range of kcat/Km values for these relatively short peptide substrates.