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Colivelin

*This product has been discontinued!*
Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN). Colivelin is constructed as activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R) HNG17, which is a potent HN derivative. Cell death induced by overexpressed familial Alzheimer's disease (FAD)-causative genes and beta-amyloid (1-43) can be completely suppressed by colivelin. Colivelin administered intraperitoneally suppresses memory impairment and may serve as a novel drug candidate to treat Alzheimer's disease.
RP20167
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Description

Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN). Colivelin is constructed as activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R) HNG17, which is a potent HN derivative. Cell death induced by overexpressed familial Alzheimer's disease (FAD)-causative genes and beta-amyloid (1-43) can be completely suppressed by colivelin. Colivelin administered intraperitoneally suppresses memory impairment and may serve as a novel drug candidate to treat Alzheimer's disease.
Synonyms

Colivelin

Overview
Sequence
{Ser}{Ala}{Leu}{Leu}{Arg}{Ser}{Ile}{Pro}{Ala}{Pro}{Ala}{Gly}
{Ala}{Ser}{Arg}{Leu}{Leu}{Leu}{Leu}{Thr}{Gly}{Glu}{Ile}{Asp}
{Leu}{Pro}
Sequence Shortening SALLRSIPAPAGASRLLLLTGEIDLP
Molecular Formula C119H206N32O35
Molecular Weight 2645.1
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Properties
Storage Store at -20°C. Keep tightly closed. Store in a cool dry place.
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