Overview

At GenScript, our Plasmid DNA Preparation Service caters to both small research labs and large-scale biotech and pharmaceutical companies. We deliver high-quality plasmid DNA with 100% full insert sequence accuracy and guarantee your desired yield, from microgram to gram level, regardless of the plasmid type.

We provide a variety of quantities and quality options tailored to meet your specific application needs. Our comprehensive QC options support diverse applications, ranging from general molecular biology to animal studies. With extensive experience in downstream applications, including mRNA plasmids, AAV plasmids, and lentivirus plasmids, we specialize in handling complex features such as extended poly(A) and ITR sequences, delivering customized solutions for your research.

All these services are seamlessly integrated into our GenSmart™ 2.0 online ordering platform, simplifying the process with real-time quotes and pricing for new plasmids or re-preps of previously synthesized plasmids. Trust GenScript to deliver your plasmid DNA with precision and reliability. Place your order today.

Why Choose GenScript?

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100% Plasmid Yield Guarantee

  • For all plasmid types and projects
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Comprehensive QC: All Grades, Any Quantity

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Manufactured in Piscataway, NJ

  • TAT starting from 2 days
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Perfect Plasmid DNA for Your Research

Service Specifications

  • Service Details

  • Quality Control

Tier 1 Tier 2 Tier 3
Application For all-purpose use Optimized for transfection studies Optimized for animal studies
Turnaround Time (BD) Starting from 2 days Starting from 3 days Starting from 2 weeks
Scale
(Guarantee Yield)
≥10 µg ≥10 µg ≥5 mg
Homogeneity Predominantly supercoil ≥80% supercoil ≥90% supercoil
Endotoxin Level

Low endotoxin
≤0.01 EU/µg

≤ 0.1 EU/μg
≤0.01 EU/μg
≤0.005 EU/μg

≤0.01 EU/μg
≤0.005 EU/μg

Quality Controls Please refer to Quality Control tab for more details
Benefits
  • Plasmid yield guaranteed across all service tiers and plasmid types, with flexible pricing for different quantities
  • Comprehensive default and optional quality control options for all applications
  • Specialization in AAV ITR and poly(A) sequence preparations

Please Note:

  • Get an instant quote and estimated turnaround time for plasmid DNA preparation projects via GenSmart™ 2.0 online ordering platform.
  • Turnaround times indicate production time, overnight or express shipping available from GenScript‘s USA local production facility in Piscataway, New Jersey.
  • The original Research Grade plasmid DNA combines "Predominantly supercoil" with “Low endotoxin" endotoxin level. The original Industrial Grade plasmid DNA combines "≥80%" supercoil level with "≤0.01 EU/µg" endotoxin level. And the original Pre-clinical Grade plasmid DNA combines "≥90%" supercoil level with "≤0.01 EU/µg" endotoxin level.
  • Predominately supercoiled: While we do not guarantee a specific supercoil content, our quality assessment protocol includes agarose gel analysis to evaluate the supercoiled ratio. According to our internal data, over 80% of the plasmids prepared by the GenScript platform have a supercoiled DNA content of 80% or higher.
  • Low endotoxin: While we do not guarantee a specific endotoxin level, according to our internal data, over 95% of the plasmids prepared by the GenScript platform achieve an endotoxin level of 0.1 EU/µg or lower.

Your Research, We Guarantee

At GenScript, we bring extensive experience and a suite of advanced solutions to support mRNA and AAV research. Our proprietary tools—applied vectors, specialized host strains, optimized production processes, and more—are specifically designed to overcome challenges such as extended poly(A) and ITR regions that can complicate plasmid preparation. With these innovative solutions, we ensure sequence accuracy and integrity, empowering you to conduct your research with confidence and success.

mRNA Plasmid Solutions mRNA Plasmid Solutions

Reliable high-quality IVT DNA templates

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AAV Plasmid Solutions gene synthesis icon

Empowering your research with reliable AAV plasmids

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Easy Ordering with GenSmart™ 2.0 Online Ordering Platform

Order gene synthesis via GenSmart™ 2.0 with ease

Order plasmid DNA preparation via GenSmart™ 2.0

  • Bundle with your gene synthesis projects, re-prep previously synthesized constructs, or provide us with your templates.
  • Choice of starting materials: DNA templates, glycerol stock, or bacterial colonies.
  • Receive an instant quote and place your order.

Off-the-Shelf Plasmids

Next-day shipping of our most popular plasmids including AAV/LVV packaging and expression vectors, CRISPR vectors, mRNA template vectors and more.

Testimonials

Resources

GenSmart™ 2.0 Online Ordering
GenSmart™ 2.0 Online Ordering

4 steps to get your quote or order your clonal gene.

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GenSmart™ 2.0 Quick User Manual
GenSmart™ 2.0 Quick User Manual

Essential steps and tips to get familiar with GenSmart™ 2.0

Free Download
GenSmart™ Codon Optimization
GenSmart™ Codon Optimization

A free online tool for codon optimization to improve gene expression and more.

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GenSmart™ Vector Design
GenSmart™ Vector Design

A free online tool to design your own plasmid vectors.

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GenSmart™ Vector Design
AAV ITR Guarantee service

Learn more about GenScript’s proprietary AAV ITR Guarantee platform

Free Download
GenSmart™ Vector Design
Gene Therapy Tidbits

Learn how improved ITR integrity can impact AAV plasmid expression and accelerate your gene therapy pipeline!

Free Download

Get in Touch
With GenScript Experts

Get in Touch with GenScript Services
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