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Never settle with less!
Ever worry your oligo library did not cover 100% of your wanted mutant? Having to drop some of your designs because synthetic library too expensive?
From now on, you will never have to drop a single research idea because of limited budgets. GenScript’s semiconductor-based electrochemical oligo pool synthesis platform can generate thousands of oligonucleotides in a coverslip-sized chip, at affordable pricing. Our flexible chip capacity and lower than 0.2₵/base price can help you to turn all your ideas to reality.
gRNA libraries, are ideal for high-throughput screening of important molecular targets, used wildly in research for cancer therapy, diagnostics, breading and microorganism engineering. These libraries leverage the efficiency and specificity of the CRISPR gene editing technology to either knock-out gene expression or transcriptionally activate genes in the genome.
GenScript offers a variety of gRNA library options:
A pooled lentiviral screen can be performed to identify genes that regulate cellular responses and signaling pathways, or to discover novel gene functions. Pooled screening libraries can consist of as few as 50 constructs up to many thousands. GenScript’s siRNA Design Center and chip based synthesis platform make the lentivirus-based RNAi libraries available to verify your research hypothesis.
Mutant libraries, also known as directed evolution, are increasingly used to identify structurally and functionally critical residues and to optimize protein function. GenScript offers various of mutant libraries customized for industrial enzyme development, metabolic engineering, protein engineering and antibody drug development. Our newly developed chip oligo synthesis technology allows full control of mutation ratio and creates near 100% coverage.
Molecular diagnostic based on NGS technology has shown great potential to revolutionize the IVD market. High quality oligo pool plays critical role in target enrichment during library preparation. Our oligo pool synthesis platform is based on high-throughput synthesis of oligos on a single chip, allowing us to provide you with a large amount of hybridization probes following amplification. This is a fast and economic approach to optimize gene panels in the R&D stage of cancer diagnostic kit development. The gene panel screening results can be verified using our column probes synthesis service. GenScript always aims to provide a total solution for your research.
* If you need oligos of 171-200 nt in length, please contact us for pricing and availability.
The customer ordered 12,000 125 nt oligo pool. By using our proprietary semi-conductor array synthesis platform, we delivered the product within 7 days. Post synthesis we amplified the oligo pool and performed NGS via illumina Hi-Seq. Results are shown in the figure to the left.
Please contact us if you need immediate assistance.
Please contact us (phone: 1-877-436-7274 or email: firstname.lastname@example.org),if you need immediate assistance.