Protease Target Solutions
Approximately 500 putative proteases have been identified in human genome. Through controlling complex proteolytic activities, proteases participate in a wide range of physiological processes. Many of them have been utilized as targets for therapeutic intervention, such as Dipeptidyl Peptidase IV (DPP-IV) and HIV-1 protease for diabetes and AIDS, respectively. However, precise roles of many proteases remain unknown in many diseases.
To speed up the drug discovery process that involves protease targets, GenScript has developed a protease assay panel for compound screening. Moreover, custom assay development service is available to facilitate your drug screening against protease targets of your interest.
- Assay development for high throughput screening
- Protease substrate determination based on peptide library
- High throughput compound screening with full panel 72 proteases
Assay Setup Showcases
Reference Compound: NNGH
Measured Product: Mca-peptides
Detection Technique: Fluorimetry
Name: Factor Xa
Reference Compound: PPACK
Measured Product: pNA
Detection Technique: Colorimetry
GenScript has assembled the largest protease panel in the industry which covers over 70 proteases. Our comprehensive protease panel profiling will boost your capability in evaluating structure-activity relationship (SAR) in drug development process.
If you can't find protease of interest in ready catalog assays, please feel free to contact us for support.
|DPP (Dipeptidyl Peptidases)||DPP3|
|MMPs (Matrix Metalloproteinases)||MMP1|
|Other Proteases||IDE (insulysin)|
|Tissue plasminogen activator|
|DPP (Dipeptidyl Peptidases)||DPP-4|
|Complement Proteases||Complement C1r Subcomponent|
|Complement C1s Subcomponent|
|Complement MASP3 Catalytic Domain|
|Other Proteases||Airway trypsin-like protease/HAT|
|Matriptase/ST14 Catalytic Domain|
|Prolyl oligopeptidase PreP|