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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
6PGD_HUMAN, Homo sapiens (human) PGD 6-phosphogluconate dehydrogenase, decarboxylating Functions
wild_type
Starting from $1600,
4 weeks
Protein Domains
mutant
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Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 6-phosphogluconate dehydrogenase, decarboxylating;
Alternative name(s):
Protein IDs
(Accession numbers)
UniProtKB
 P52209
NCBI RefSeq

NP_002622.2, NM_002631.2.
Organism
Latin Name/
(Common Name)
Homo sapiens (Human).
Taxonomic Identifier (NCBI)
 9606
Gene Names
 PGD [GenPool]
GeneID

5226
Genome
Annotation (Ensembl)

ENST00000270776, ENSP00000270776; ENSG00000142657
Protein Sequence
 
SEQUENCE   483 AA;  53140 MW;  6CEFC0077D1283E3 CRC64;
MAQADIALIG LAVMGQNLIL NMNDHGFVVC AFNRTVSKVD DFLANEAKGT KVVGAQSLKE
MVSKLKKPRR IILLVKAGQA VDDFIEKLVP LLDTGDIIID GGNSEYRDTT RRCRDLKAKG
ILFVGSGVSG GEEGARYGPS LMPGGNKEAW PHIKTIFQGI AAKVGTGEPC CDWVGDEGAG
HFVKMVHNGI EYGDMQLICE AYHLMKDVLG MAQDEMAQAF EDWNKTELDS FLIEITANIL
KFQDTDGKHL LPKIRDSAGQ KGTGKWTAIS ALEYGVPVTL IGEAVFARCL SSLKDERIQA
SKKLKGPQKF QFDGDKKSFL EDIRKALYAS KIISYAQGFM LLRQAATEFG WTLNYGGIAL
MWRGGCIIRS VFLGKIKDAF DRNPELQNLL LDDFFKSAVE NCQDSWRRAV STGVQAGIPM
PCFTTALSFY DGYRHEMLPA SLIQAQRDYF GAHTYELLAK PGQFIHTNWT GHGGTVSSSS
YNA
General annotation
Function
 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity).
Cofactor
Subunit structure
 Homodimer.
Subcellular location

Cytoplasm (By similarity).
Tissue specificity
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "Identification of a cDNA encoding 6-phosphogluconate dehydrogenasefrom a human heart cDNA library.";,Tsui S.K.W., Chan J.Y., Waye M.M.Y., Fung K.-P., Lee C.-Y.;,Biochem. Genet. 34:367-373(1996)., PubMeb:8978909 DOI:10.1007/BF00554412

  • "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

  • "Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";,Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;,Science 325:834-840(2009).,PubMeb:19608861 DOI:10.1126/science.1175371

  • "Initial characterization of the human central proteome.";,Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;,BMC Syst. Biol. 5:17-17(2011).,PubMeb:21269460 DOI:10.1186/1752-0509-5-17

  • "Structure of human phosphogluconate dehydrogenase in complex withNADPH at 2.53 A.";,Submitted (SEP-2009) to the PDB data bank.

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
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Protein Domain Databases
InterPro

IPR008927, 6-PGluconate_DH_C-like.

IPR006114, 6PGDH_C.

IPR006113, 6PGDH_decarbox.

IPR006115, 6PGDH_NADP-bd.

IPR006184, 6PGdom_BS.

IPR013328, DH_multihelical.

IPR012284, Fibritin/6PGD_C-extension.

IPR016040, NAD(P)-bd_dom.
Gene3D

G3DSA:1.20.5.320, Fibritin/6PGD_C-extension; 1.

G3DSA:3.40.50.720, NAD(P)-bd; 1.

G3DSA:1.10.1040.10, Opine_DH; 1.
PANTHER
Pfam

PF00393, 6PGD; 1.

PF03446, NAD_binding_2; 1.
PRINTS
SUPFAM

SSF48179, 6DGDH_C_like; 1.
PROSITE

PS00461, 6PGD; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
2JKV X-ray 2.53 A A/B/C/D/E/F 1-483 [>>]
Sequence
Annotation
Feature key
Position(s)
Length
Description
Initiator methionine 1 1 Removed (By similarity).
Polypeptide chain 2 - 483 482 6-phosphogluconate dehydrogenase, /FTId=PRO_0000090063.
Nucleotide phosphate-binding region 10 - 15 6 NADP.
Nucleotide phosphate-binding region 33 - 35 3 NADP.
Nucleotide phosphate-binding region 75 - 77 3 NADP.
Nucleotide phosphate-binding region 478 - 481 4 NADP; shared with dimeric partner.
Region 129 - 131 3 Substrate binding (By similarity).
Region 187 - 188 2 Substrate binding (By similarity).
Amino acid(s) 184 1 Proton acceptor (By similarity).
Amino acid(s) 191 1 Proton donor (By similarity).
Binding 103 1 NADP.
Binding 103 1 Substrate (By similarity).
Binding 192 1 Substrate (By similarity).
Binding 261 1 Substrate; via amide nitrogen (By
Binding 288 1 Substrate (By similarity).
Binding 447 1 Substrate; shared with dimeric partner
Binding 453 1 Substrate; shared with dimeric partner
Posttranslational modification of a residue 38 1 N6-acetyllysine.
Posttranslational modification of a residue 59 1 N6-acetyllysine.
Posttranslational modification of a residue 76 1 N6-acetyllysine.
Posttranslational modification of a residue 154 1 N6-acetyllysine.
Posttranslational modification of a residue 309 1 N6-acetyllysine.
Natural variance 268 1 A -> S (in dbSNP:rs11547610). /FTId=VAR_048104.
Different sources report differing sequences 118 1 A -> G (in Ref. 1; AAA75302).
Different sources report differing sequences 135 1 A -> P (in Ref. 1; AAA75302).
Strand 4 - 9 6
Strand 29 - 31 3
Strand 70 - 73 4
Strand 97 - 99 3
Strand 122 - 124 3
Strand 169 - 171 3
Strand 455 - 457 3
Strand 463 - 465 3
Helix 17 - 24 8
Helix 37 - 44 8
Helix 58 - 63 6
Helix 80 - 88 9
Helix 89 - 91 3
Helix 106 - 118 13
Helix 147 - 150 4
Helix 151 - 157 7
Helix 182 - 187 6
Helix 195 - 207 13
Helix 213 - 223 11
Helix 231 - 241 11
Helix 251 - 253 3
Helix 266 - 273 8
Helix 284 - 292 9
Helix 294 - 303 10
Helix 316 - 336 21
Helix 340 - 348 9
Helix 360 - 362 3
Helix 376 - 382 7
Helix 389 - 391 3
Helix 393 - 411 19
Helix 421 - 430 10
Helix 440 - 449 10
Turn 45 - 47 3
Turn 224 - 228 5
Protein-protein
Interaction
Databases
DIP
IntAct

P52209
MINT

MINT-1415782
STRING

P52209
Binary Interactions
With
Entry
#Exp.
IntAct
NAA38O95777 1EBI-372761, EBI-347779
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome

REACT_474, Metabolism of carbohydrates.
Phylogenomic Database
HOVERGEN

HBG000029
InParanoid

P52209
OMA

CIIRAGF
OrthoDB

EOG4C2H9D
Proteomics
Database (PRIDE)

P52209
Comparative
Toxicogenomics
Database (CTD)

5226
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Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262