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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
B4GN1_RAT, Rattus norvegicus (Norway rat) B4galnt1 GalNAc-T Functions
wild_type
Starting from $1920,
5 weeks
Protein Domains
mutant
Quote

Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Beta-1,4 N-acetylgalactosaminyltransferase 1;
Alternative name(s):
 (N-acetylneuraminyl)-galactosylglucosylceramide
GM2/GD2 synthase
GalNAc-T
Protein IDs
(Accession numbers)
UniProtKB
 Q10468
NCBI RefSeq

NP_074051.1, NM_022860.2.
Organism
Latin Name/
(Common Name)
Rattus norvegicus (Rat).
Taxonomic Identifier (NCBI)
 10116
Gene Names
 B4galnt1 [GenPool]
GeneID

64828
Genome
Annotation (Ensembl)

ENSRNOT00000046099, ENSRNOP00000048586; ENSRNOG00000004839
Protein Sequence
 
SEQUENCE   533 AA;  59279 MW;  43EF653FB07EA651 CRC64;
MRLDRRALYA LVLLLACASL GLLYASTRDA PGLPNPLALW SPPQGPPRLD LLDLATEPRY
AHIPVRIKEQ VVGLLAQNNC SCESSGGRFA LPFLRQVRAI DFTKAFDAEE LRAVSISREQ
EYQAFLARSR SLADQLLIAP ANSPLQYPLQ GVEVQPLRSI LVPGLSLQEA SVQEIYQVNL
IASLGTWDVA GEVTGVTLTG EGQSDLTLAS PILDKLNRQL QLVTYSSRSY QANTADTVRF
STKGHEVAFT ILIRHPPNPR LYPPSSLPQG AQYNISALVT VATKTFLRYD RLRALIASIR
RFYPTVTIVI ADDSDKPERI SDPHVEHYFM PFGKGWFAGR NLAVSQVTTK YVLWVDDDFV
FTARTRLEKL VDVLERTPLD LVGGAVREIS GYATTYRQLL SVEPGAPGFG NCLRQKQGFH
HELAGFPNCV VTDGVVNFFL ARTDKVRQVG FDPRLNRVAH LEFFLDGLGS LRVGSCSDVV
VDHASKVKLP WTSKDPGAEL YARYRYPGSL DQSQVAKHRL LFFKHRLQCM TAE
General annotation
Function
 Involved in the biosynthesis of gangliosides GM2, GD2 and asialo-GM2.
Cofactor
Subunit structure
 Homodimer; disulfide-linked (By similarity).
Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein.
Tissue specificity
 Strongly expressed in brain, testis, spleen, and to a lesser extent in liver.
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "Beta-1,4-N-acetylgalactosaminyltransferase can synthesize bothasialoglycosphingolipid GM2 and glycosphingolipid GM2 in vitro and invivo: isolation and characterization of a beta-1,4-N-acetylgalactosaminyltransferase cDNA clone from rat ascites hepatomacell line AH7974F.";,Hidari J.K., Ichikawa S., Furukawa K., Yamasaki M., Hirabayashi Y.;,Biochem. J. 303:957-965(1994)., PubMeb:7980468

  • "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR001173, Glyco_trans_2.

IPR011143, GM2_synthase.
Gene3D
PANTHER
Pfam

PF00535, Glycos_transf_2; 1.
PRINTS
SUPFAM
PROSITE
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Polypeptide chain 1 - 533 533 Beta-1,4 N- /FTId=PRO_0000059102.
Topological domain 1 - 7 7 Cytoplasmic (Potential).
Topological domain 26 - 533 508 Lumenal (Potential).
Transmembrane region 8 - 25 18 Helical; Signal-anchor for type II
Glycosylation site 79 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 274 1 N-linked (GlcNAc...) (Potential).
Disulfide bond 80 1 Interchain (with C-412) (By similarity).
Disulfide bond 82 1 Interchain (with C-529) (By similarity).
Disulfide bond 412 1 Interchain (with C-80) (By similarity).
Disulfide bond 429 - 476 48 By similarity.
Disulfide bond 529 1 Interchain (with C-82) (By similarity).
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

Q10468
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG004812
InParanoid
OMA
OrthoDB

EOG4WH8KK
Proteomics
Database (PRIDE)

Q10468
Comparative
Toxicogenomics
Database (CTD)

2583
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