• English
  • Sign In
    Please Sign In
    Sign In
    New to GenScript?
    Register
  • Contact Us
×
Contact us now: +1-877-436-7274
Recombinant Protein & rAb Services
24 hour
Home » Recombinant Protein & rAb Services » PROTBANK™ Protein Database
Email to GenScript

Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

  • THAT AND
  • THAT AND

Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
C3AR_HUMAN, Homo sapiens (human) C3AR1 C3a anaphylatoxin chemotactic receptor Functions
wild_type
Quote
Protein Domains
mutant
Quote

Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 C3a anaphylatoxin chemotactic receptor;
Alternative name(s):
Protein IDs
(Accession numbers)
UniProtKB
 Q16581
NCBI RefSeq

NP_004045.1, NM_004054.2.
Organism
Latin Name/
(Common Name)
Homo sapiens (Human).
Taxonomic Identifier (NCBI)
 9606
Gene Names
 C3AR1 [GenPool]
GeneID

719
Genome
Annotation (Ensembl)

ENST00000307637, ENSP00000302079; ENSG00000171860
Protein Sequence
 
SEQUENCE   482 AA;  53864 MW;  287E219D98CED203 CRC64;
MASFSAETNS TDLLSQPWNE PPVILSMVIL SLTFLLGLPG NGLVLWVAGL KMQRTVNTIW
FLHLTLADLL CCLSLPFSLA HLALQGQWPY GRFLCKLIPS IIVLNMFASV FLLTAISLDR
CLVVFKPIWC QNHRNVGMAC SICGCIWVVA FVMCIPVFVY REIFTTDNHN RCGYKFGLSS
SLDYPDFYGD PLENRSLENI VQPPGEMNDR LDPSSFQTND HPWTVPTVFQ PQTFQRPSAD
SLPRGSARLT SQNLYSNVFK PADVVSPKIP SGFPIEDHET SPLDNSDAFL STHLKLFPSA
SSNSFYESEL PQGFQDYYNL GQFTDDDQVP TPLVAITITR LVVGFLLPSV IMIACYSFIV
FRMQRGRFAK SQSKTFRVAV VVVAVFLVCW TPYHIFGVLS LLTDPETPLG KTLMSWDHVC
IALASANSCF NPFLYALLGK DFRKKARQSI QGILEAAFSE ELTRSTHCPS NNVISERNST
TV
General annotation
Function
 Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production.
Cofactor
Subunit structure
Subcellular location

Cell membrane; Multi-pass membrane protein.
Tissue specificity
 Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues.
Induction
Domain
Post-translational modification

Among the sulfation sites Tyr-174 is essential for binding ofC3a anaphylatoxin.
Involvement in disease

References

  • "cDNA cloning of a novel G protein-coupled receptor with a largeextracellular loop structure.";,Roglic A., Prossnitz E.R., Cavanagh S.L., Pan Z., Zou A., Ye R.D.;,Biochim. Biophys. Acta 1305:39-43(1996)., PubMeb:8605247 DOI:10.1016/0167-4781(95)00209-X

  • "Expression cloning of the human C3a anaphylatoxin receptor (C3aR)from differentiated U-937 cells.";,Crass T., Raffetseder U., Martin U., Grove M., Klos A., Koehl J.,Bautsch W.;,Eur. J. Immunol. 26:1944-1950(1996)., PubMeb:8765043 DOI:10.1002/eji.1830260840

  • Bautsch W.;,Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases.

  • "Molecular cloning and characterization of the human anaphylatoxin C3areceptor.";,Ames R.S., Li Y., Sarau H.M., Nuthulaganti P., Foley J.J., Ellis C.,Zeng Z., Su K., Jurewicz A.J., Hertzberg R.P., Bergsma D.J., Kumar C.;,J. Biol. Chem. 271:20231-20234(1996)., PubMeb:8702752 DOI:10.1074/jbc.271.34.20231

  • "Genome-wide discovery and analysis of human seven transmembrane helixreceptor genes.";,Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;,Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.

  • "cDNA clones of human proteins involved in signal transductionsequenced by the Guthrie cDNA resource center (www.cdna.org).";,Kopatz S.A., Aronstam R.S., Sharma S.V.;,Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.

  • Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.

  • "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

  • "Sulfation of tyrosine 174 in the human C3a receptor is essential forbinding of C3a anaphylatoxin.";,Gao J., Choe H., Bota D., Wright P.L., Gerard C., Gerard N.P.;,J. Biol. Chem. 278:37902-37908(2003).,PubMeb:12871936 DOI:10.1074/jbc.M306061200

Order Custom
Gene & Protein
Secured Online Quotation
Email: [email protected]
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262
Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR000276, 7TM_GPCR_Rhodpsn.

IPR002234, Anphylx_rcpt.

IPR001644, C3A_anaphtx_rcpt.

IPR017452, GPCR_Rhodpsn_supfam.
Gene3D
PANTHER
Pfam

PF00001, 7tm_1; 2.
PRINTS

PR01104, ANPHYLATOXNR.

PR01060, C3ANPHYLTXNR.

PR00237, GPCRRHODOPSN.
SUPFAM
PROSITE

PS00237, G_PROTEIN_RECEP_F1_1; 1.

PS50262, G_PROTEIN_RECEP_F1_2; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Polypeptide chain 1 - 482 482 C3a anaphylatoxin chemotactic receptor. /FTId=PRO_0000069202.
Topological domain 1 - 23 23 Extracellular (Potential).
Topological domain 47 - 57 11 Cytoplasmic (Potential).
Topological domain 81 - 96 16 Extracellular (Potential).
Topological domain 119 - 139 21 Cytoplasmic (Potential).
Topological domain 161 - 340 180 Extracellular (Potential).
Topological domain 361 - 377 17 Cytoplasmic (Potential).
Topological domain 401 - 417 17 Extracellular (Potential).
Topological domain 439 - 482 44 Cytoplasmic (Potential).
Transmembrane region 24 - 46 23 Helical; Name=1; (Potential).
Transmembrane region 58 - 80 23 Helical; Name=2; (Potential).
Transmembrane region 97 - 118 22 Helical; Name=3; (Potential).
Transmembrane region 140 - 160 21 Helical; Name=4; (Potential).
Transmembrane region 341 - 360 20 Helical; Name=5; (Potential).
Transmembrane region 378 - 400 23 Helical; Name=6; (Potential).
Transmembrane region 418 - 438 21 Helical; Name=7; (Potential).
Posttranslational modification of a residue 174 1 Sulfotyrosine.
Posttranslational modification of a residue 184 1 Sulfotyrosine.
Posttranslational modification of a residue 318 1 Sulfotyrosine.
Glycosylation site 9 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 194 1 N-linked (GlcNAc...) (Potential).
Disulfide bond 95 - 172 78 By similarity.
Natural variance 136 1 V -> A (in dbSNP:rs11567806). /FTId=VAR_019164.
Different sources report differing sequences 151 1 F -> C (in Ref. 4; AAC50657).
Different sources report differing sequences 203 1 P -> R (in Ref. 1; AAC50374).
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

Q16581
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome

REACT_14797, Signaling by GPCR.
Phylogenomic Database
HOVERGEN

HBG002433
InParanoid

Q16581
OMA

LWVAGLK
OrthoDB

EOG4PC9S8
Proteomics
Database (PRIDE)

Q16581
Comparative
Toxicogenomics
Database (CTD)

719
Order Your Custom Protein
Secured Online Quotation
Email: [email protected]
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262