Protein Annotations for Muscle cadherin, CAD15

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Name	Gene Symbol	Rec Full Name	Protein Information	Quick Quote	Price, Turnaround
CAD15_HUMAN, Homo sapiens (human)	CDH15	Muscle cadherin	Functions		Quote
CAD15_HUMAN, Homo sapiens (human)	CDH15	Muscle cadherin	Protein Domains		Quote

Protein Names

Recommended name:	Cadherin-15;
Alternative name(s):	Cadherin-14 Muscle cadherin

Protein IDs
(Accession numbers)

UniProtKB	P55291
NCBI RefSeq	NP_004924.1, NM_004933.2.

Organism

Latin Name/ (Common Name)	Homo sapiens (Human).
Taxonomic Identifier (NCBI)	9606

Gene Names

CDH15 [GenPool]

GeneID

1013

Genome
Annotation (Ensembl)

ENST00000289746, ENSP00000289746; ENSG00000129910

Protein Sequence

SEQUENCE   814 AA;  88916 MW;  618A817DBF2B3343 CRC64;
MDAAFLLVLG LLAQSLCLSL GVPGWRRPTT LYPWRRAPAL SRVRRAWVIP PISVSENHKR
LPYPLVQIKS DKQQLGSVIY SIQGPGVDEE PRGVFSIDKF TGKVFLNAML DREKTDRFRL
RAFALDLGGS TLEDPTDLEI VVVDQNDNRP AFLQEAFTGR VLEGAVPGTY VTRAEATDAD
DPETDNAALR FSILQQGSPE LFSIDELTGE IRTVQVGLDR EVVAVYNLTL QVADMSGDGL
TATASAIITL DDINDNAPEF TRDEFFMEAI EAVSGVDVGR LEVEDRDLPG SPNWVARFTI
LEGDPDGQFT IRTDPKTNEG VLSIVKALDY ESCEHYELKV SVQNEAPLQA AALRAERGQA
KVRVHVQDTN EPPVFQENPL RTSLAEGAPP GTLVATFSAR DPDTEQLQRL SYSKDYDPED
WLQVDAATGR IQTQHVLSPA SPFLKGGWYR AIVLAQDDAS QPRTATGTLS IEILEVNDHA
PVLAPPPPGS LCSEPHQGPG LLLGATDEDL PPHGAPFHFQ LSPRLPELGR NWSLSQVNVS
HARLRPRHQV PEGLHRLSLL LRDSGQPPQQ REQPLNVTVC RCGKDGVCLP GAAALLAGGT
GLSLGALVIV LASALLLLVL VLLVALRARF WKQSRGKGLL HGPQDDLRDN VLNYDEQGGG
EEDQDAYDIS QLRHPTALSL PLGPPPLRRD APQGRLHPQP PRVLPTSPLD IADFINDGLE
AADSDPSVPP YDTALIYDYE GDGSVAGTLS SILSSQGDED QDYDYLRDWG PRFARLADMY
GHPCGLEYGA RWDHQAREGL SPGALLPRHR GRTA

General annotation

Function	Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
Cofactor
Subunit structure
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Expressed in the brain and cerebellum.
Induction
Domain
Post-translational modification
Involvement in disease	Note=A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in CDH15 are the cause of mental retardation autosomal dominant type 3 (MRD3) [MIM:612580]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.

References

"Identification of human cadherin-14, a novel neurally specific typeII cadherin, by protein interaction cloning.";,Shibata T., Shimoyama Y., Gotoh M., Hirohashi S.;,J. Biol. Chem. 272:5236-5240(1997)., PubMeb:9030594 DOI:10.1074/jbc.272.8.5236
"The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504
"Alterations in CDH15 and KIRREL3 in patients with mild to severeintellectual disability.";,Bhalla K., Luo Y., Buchan T., Beachem M.A., Guzauskas G.F., Ladd S.,Bratcher S.J., Schroer R.J., Balsamo J., DuPont B.R., Lilien J.,Srivastava A.K.;,Am. J. Hum. Genet. 83:703-713(2008).,PubMeb:19012874 DOI:10.1016/j.ajhg.2008.10.020

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Protein Domain Databases

InterPro	IPR002126, Cadherin. IPR015919, Cadherin-like. IPR020894, Cadherin_CS. IPR000233, Cadherin_cytoplasmic-dom.
Gene3D	G3DSA:2.60.40.60, Cadherin; 4.
PANTHER
Pfam	PF00028, Cadherin; 4. PF01049, Cadherin_C; 1.
PRINTS	PR00205, CADHERIN.
SUPFAM	SSF49313, Cadherin; 5.
PROSITE	PS00232, CADHERIN_1; 2. PS50268, CADHERIN_2; 5.

3D Structure
Database (PDB)

Entry

Method

Resolution (A)

Chain

Positions

PDBsum

Sequence
Annotation

Feature key	Position(s)	Length	Description
Signal sequence	1 - 21	21	Potential.
Propeptide	22 - 60	39	Potential. /FTId=PRO_0000003805.
Polypeptide chain	61 - 814	754	Cadherin-15. /FTId=PRO_0000003806.
Topological domain	61 - 606	546	Extracellular (Potential).
Topological domain	627 - 814	188	Cytoplasmic (Potential).
Transmembrane region	607 - 626	20	Helical; (Potential).
Domain	61 - 152	92	Cadherin 1.
Domain	153 - 260	108	Cadherin 2.
Domain	261 - 375	115	Cadherin 3.
Domain	376 - 481	106	Cadherin 4.
Domain	482 - 590	109	Cadherin 5.
Glycosylation site	227	1	N-linked (GlcNAc...) (Potential).
Glycosylation site	531	1	N-linked (GlcNAc...) (Potential).
Glycosylation site	538	1	N-linked (GlcNAc...) (Potential).
Glycosylation site	576	1	N-linked (GlcNAc...) (Potential).
Natural variance	8	1	V -> L (in MRD3; uncertain pathological /FTId=VAR_054966.
Natural variance	60	1	R -> C (in MRD3; affects cell-cell /FTId=VAR_054967.
Natural variance	92	1	R -> W (in MRD3; affects cell-cell /FTId=VAR_054968.
Natural variance	122	1	A -> V (in MRD3; affects cell-cell /FTId=VAR_054969.
Mutagenesis	103	1	K->R: No effect on cell-cell adhesion.
Mutagenesis	109	1	M->T: No effect on cell-cell adhesion.

Protein-protein
Interaction
Databases

DIP
IntAct
MINT
STRING	P55291

Binary Interactions

With

Entry

#Exp.

IntAct

Enzyme and Pathway Databases

Pathway
Interaction DB

Reactome

REACT_20676, Cell junction organization.

REACT_21303, Myogenesis.

Phylogenomic Database

HOVERGEN	HBG106438
InParanoid	P55291
OMA	LDYESCE
OrthoDB	EOG4BRWK5

Proteomics
Database (PRIDE)

P55291

Comparative
Toxicogenomics
Database (CTD)

1013

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