Protein Annotations for Stem cell growth factor, CLC11

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THAT AND

Reviewed (UniProtKB/Swiss-Prot)

Name	Gene Symbol	Rec Full Name	Protein Information	Quick Quote	Price, Turnaround
CLC11_RAT, Rattus norvegicus (Norway rat)	Clec11a	Stem cell growth factor	Functions		Starting from $1600, 4 weeks
CLC11_RAT, Rattus norvegicus (Norway rat)	Clec11a	Stem cell growth factor	Protein Domains		Quote

Protein Names

Recommended name:	C-type lectin domain family 11 member A;
Alternative name(s):	Lymphocyte secreted C-type lectin Stem cell growth factor

Protein IDs
(Accession numbers)

UniProtKB	O88201
NCBI RefSeq	NP_001012477.1, NM_001012459.1.

Organism

Latin Name/ (Common Name)	Rattus norvegicus (Rat).
Taxonomic Identifier (NCBI)	10116

Gene Names

Clec11a [GenPool]

GeneID

29313

Genome
Annotation (Ensembl)

ENSRNOT00000025949, ENSRNOP00000025949; ENSRNOG00000019138

Protein Sequence

SEQUENCE   328 AA;  36388 MW;  C115188AC23D6257 CRC64;
MQAAWLLGAL LVPHLLSFGH GARGHGKEWE GVWGGALEEE RDRESLMLKN LQEALGLPTG
VGNKDNLAEN SEGKEVWEAT ETQGEEEEEE TTTTPSSSPT PFPSPSPTSE DTVTYILGRL
ASLDAGLHQL HIRLHVLDTR VVELTQGLRR LRDAASDTRD SVQALKEVQV RSEQEHGRLE
GCLKGLRLGH KCFLLSRDFE TQAAAQARCK ARGGSLAQPA DRQQMDALSR YLRAALAPYN
WPVWLGVHDR RSEGLYLFEN GQRVSFFAWH RALSPESGAQ PSAASHPLSP DQPNGGILEN
CVAQASDDGS WWDHDCERRL YFVCEFPF

General annotation

Function	Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation (By similarity).
Cofactor
Subunit structure
Subcellular location	Cytoplasm (By similarity). Secreted (By similarity).
Tissue specificity
Induction
Domain
Post-translational modification	O-glycosylated. Probably sulfated on the O-glycans (Bysimilarity).
Involvement in disease

References

"Isolation and characterization of a cDNA for human, mouse, and ratfull-length stem cell growth factor, a new member of C-type lectinsuperfamily.";,Mio H., Kagami N., Yokokawa S., Kawai H., Nakagawa S., Takeuchi K.,Sekine S., Hiraoka A.;,Biochem. Biophys. Res. Commun. 249:124-130(1998)., PubMeb:9705843 DOI:10.1006/bbrc.1998.9073
"The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

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Protein Domain Databases

InterPro	IPR001304, C-type_lectin. IPR016186, C-type_lectin-like. IPR018378, C-type_lectin_CS. IPR016187, C-type_lectin_fold.
Gene3D	G3DSA:3.10.100.10, C-type_lectin-like; 1.
PANTHER
Pfam	PF00059, Lectin_C; 1.
PRINTS
SUPFAM	SSF56436, C-type_lectin_fold; 1.
PROSITE	PS00615, C_TYPE_LECTIN_1; 1. PS50041, C_TYPE_LECTIN_2; 1.

3D Structure
Database (PDB)

Entry

Method

Resolution (A)

Chain

Positions

PDBsum

Sequence
Annotation

Feature key	Position(s)	Length	Description
Signal sequence	1 - 21	21	By similarity.
Polypeptide chain	22 - 328	307	C-type lectin domain family 11 member A. /FTId=PRO_0000017470.
Domain	188 - 325	138	C-type lectin.
Disulfide bond	209 - 324	116	By similarity.
Disulfide bond	301 - 316	16	By similarity.

Protein-protein
Interaction
Databases

DIP
IntAct
MINT
STRING	O88201

Binary Interactions

With

Entry

#Exp.

IntAct

Enzyme and Pathway Databases

Pathway Interaction DB
Reactome

Phylogenomic Database

HOVERGEN	HBG052365
InParanoid	O88201
OMA	HGRLEGC
OrthoDB	EOG4PZJ7K

Proteomics
Database (PRIDE)

Comparative
Toxicogenomics
Database (CTD)

6320

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