10699

ENST00000273857, ENSP00000273857; ENSG00000145244

ENST00000502252, ENSP00000424212; ENSG00000145244

ENST00000504534, ENSP00000425684; ENSG00000145244

ENST00000504584, ENSP00000423216; ENSG00000145244

ENST00000505909, ENSP00000425401; ENSG00000145244

SEQUENCE   1042 AA;  116486 MW;  A3F1CB8EBB676F78 CRC64;
MKQSPALAPE ERCRRAGSPK PVLRADDNNM GNGCSQKLAT ANLLRFLLLV LIPCICALVL
LLVILLSYVG TLQKVYFKSN GSEPLVTDGE IQGSDVILTN TIYNQSTVVS TAHPDQHVPA
WTTDASLPGD QSHRNTSACM NITHSQCQML PYHATLTPLL SVVRNMEMEK FLKFFTYLHR
LSCYQHIMLF GCTLAFPECI IDGDDSHGLL PCRSFCEAAK EGCESVLGMV NYSWPDFLRC
SQFRNQTESS NVSRICFSPQ QENGKQLLCG RGENFLCASG ICIPGKLQCN GYNDCDDWSD
EAHCNCSENL FHCHTGKCLN YSLVCDGYDD CGDLSDEQNC DCNPTTEHRC GDGRCIAMEW
VCDGDHDCVD KSDEVNCSCH SQGLVECRNG QCIPSTFQCD GDEDCKDGSD EENCSVIQTS
CQEGDQRCLY NPCLDSCGGS SLCDPNNSLN NCSQCEPITL ELCMNLPYNS TSYPNYFGHR
TQKEASISWE SSLFPALVQT NCYKYLMFFS CTILVPKCDV NTGEHIPPCR ALCEHSKERC
ESVLGIVGLQ WPEDTDCSQF PEENSDNQTC LMPDEYVEEC SPSHFKCRSG QCVLASRRCD
GQADCDDDSD EENCGCKERD LWECPSNKQC LKHTVICDGF PDCPDYMDEK NCSFCQDDEL
ECANHACVSR DLWCDGEADC SDSSDEWDCV TLSINVNSSS FLMVHRAATE HHVCADGWQE
ILSQLACKQM GLGEPSVTKL IQEQEKEPRW LTLHSNWESL NGTTLHELLV NGQSCESRSK
ISLLCTKQDC GRRPAARMNK RILGGRTSRP GRWPWQCSLQ SEPSGHICGC VLIAKKWVLT
VAHCFEGREN AAVWKVVLGI NNLDHPSVFM QTRFVKTIIL HPRYSRAVVD YDISIVELSE
DISETGYVRP VCLPNPEQWL EPDTYCYITG WGHMGNKMPF KLQEGEVRII SLEHCQSYFD
MKTITTRMIC AGYESGTVDS CMGDSGGPLV CEKPGGRWTL FGLTSWGSVC FSKVLGPGVY
SNVSYFVEWI KRQIYIQTFL LN

• "Corin, a mosaic transmembrane serine protease encoded by a novel cDNAfrom human heart.";,Yan W., Sheng N., Seto M., Morser J., Wu Q.;,J. Biol. Chem. 274:14926-14935(1999)., PubMeb:10329693 DOI:10.1074/jbc.274.21.14926

• "Generation and annotation of the DNA sequences of human chromosomes 2and 4.";,Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,Waterston R.H., Wilson R.K.;,Nature 434:724-731(2005).,PubMeb:15815621 DOI:10.1038/nature03466

• "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

• "Localization of the mosaic transmembrane serine protease corin toheart myocytes.";,Hooper J.D., Scarman A.L., Clarke B.E., Normyle J.F., Antalis T.M.;,Eur. J. Biochem. 267:6931-6937(2000)., PubMeb:11082206DOI:10.1046/j.1432-1033.2000.01806.x

• "Corin, a transmembrane cardiac serine protease, acts as a pro-atrialnatriuretic peptide-converting enzyme.";,Yan W., Wu F., Morser J., Wu Q.;,Proc. Natl. Acad. Sci. U.S.A. 97:8525-8529(2000)., PubMeb:10880574 DOI:10.1073/pnas.150149097

• "Functional analysis of the transmembrane domain and activationcleavage of human corin: design and characterization of a solublecorin.";,Knappe S., Wu F., Masikat M.R., Morser J., Wu Q.;,J. Biol. Chem. 278:52363-52370(2003).,PubMeb:14559895 DOI:10.1074/jbc.M309991200

• "Role of glycosylation in corin zymogen activation.";,Liao X., Wang W., Chen S., Wu Q.;,J. Biol. Chem. 282:27728-27735(2007).,PubMeb:17660514 DOI:10.1074/jbc.M703687200

• "An integrated genetic and functional analysis of the role of type IItransmembrane serine proteases (TMPRSSs) in hearing loss.";,Guipponi M., Toh M.-Y., Tan J., Park D., Hanson K., Ballana E.,Kwong D., Cannon P.Z.F., Wu Q., Gout A., Delorenzi M., Speed T.P.,Smith R.J.H., Dahl H.-H.M., Petersen M., Teasdale R.D., Estivill X.,Park W.J., Scott H.S.;,Hum. Mutat. 29:130-141(2008).,PubMeb:17918732 DOI:10.1002/humu.20617