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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
DPYD_RAT, Rattus norvegicus (Norway rat) Dpyd Dihydrouracil dehydrogenase Functions
wild_type
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Protein Domains
mutant
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Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Dihydropyrimidine dehydrogenase [NADP+];
Alternative name(s):
 Dihydrothymine dehydrogenase
Dihydrouracil dehydrogenase
Protein IDs
(Accession numbers)
UniProtKB
 O89000
NCBI RefSeq

NP_112289.1, NM_031027.1.
Organism
Latin Name/
(Common Name)
Rattus norvegicus (Rat).
Taxonomic Identifier (NCBI)
 10116
Gene Names
 Dpyd [GenPool]
GeneID

81656
Genome
Annotation (Ensembl)
Protein Sequence
 
SEQUENCE   1025 AA;  111468 MW;  07859E73D249828C CRC64;
MAGVLSRDAP DIESILALNP RIQAHATLRS TMAKKLDKKH WKRNTDKNCF ICEKLENNFD
DIKHTTLGER GALREAVRCL KCADAPCQKS CPTSLDIKSF ITSIANKNYY GAAKLIFSDN
PLGLTCGMVC PTSDLCVGGC NLHATEEGPI NIGGLQQFAT EVFKAMNIPQ IRSPLLPPPE
HMPEAYSAKI ALFGAGPASI SCASFLARLG YSDITIFEKQ EYVGGLSTSE IPQFRLPYDV
VNFEIELMKD LGVKIICGKS ISTDEMTLST LKENGYKAAF IGIGLPEPKK DHIFQGLTQV
QGFYTSKDFL PLVAKGSKPG MCACHSPLPS VRGAVIVLGA GDTAFDCATS ALRCGARRVF
IVFRKGFANI RAVPEEMELA KEEKCEFLPF LSPRKVIVKD GKIVGMQFVR TEQDETGNWV
EDEEQIVRLK ADVVISPFGS VLDDPKVIEA LSPIKFNRWG LPEVNPETMQ TSEPWVFAGG
DVVGMANTTV ESVNDGKQAS WYIHEYIQAQ YGALVPSQPT LPLFYTPVDL VDISVEMAGL
RFPNPFGLAS ATPATSTPMI RRAFEAGWGF ALTKTFSLDK DIVTNVSPRI IRGTTSGPLY
GPGQSSFLNI ELISEKTAAY WCHSVTELKA DFPDNILIAS IMCSYNKNDW MELSKMAEAS
GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ SVRVPFFAKL TPNVTDIVSI
ARAAKEGGAD GVTATNTVSG LMGLKADGSP WPSVGSGKRT TYGGVSGTTI RPIALRAVTA
IARALPGFPI LATGGIDSAE SGLQFLHSGA SVLQVCSAIQ NQDFTVIEDY CTGLKALLYL
KSIEELSDWD GQSPPTMSHQ KGKPVPHIAE LMGQKLPSFG PYLERRKKIL AASKIRENDQ
NRACSPLQRK HFNSQKPIPA IKDVIGKSLQ YLGTFGELNI MEQVVALIDE EMCINCGKCY
MTCNDSGYQA IQFDPETHLP TVSDTCTGCT LCLSVCPIMD CIRMVSRATP YEPKRGLPLA
VKPVC
General annotation
Function
 Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine (By similarity).
Cofactor
 FMN (By similarity).
Subunit structure
 Homodimer (By similarity).
Subcellular location

Cytoplasm (By similarity).
Tissue specificity
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "Cloning of rat dihydropyrimidine dehydrogenase and correlation of itsmRNA increase in the rat liver with age.";,Kimura M., Fujimoto Sakata S., Matoba Y., Matsuda K., Kontani Y.,Kaneko M., Tamaki N.;,J. Nutr. Sci. Vitaminol. 44:537-546(1998)., PubMeb:9819714

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
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Protein Domain Databases
InterPro

IPR017896, 4Fe4S_Fe-S-bd.

IPR017900, 4Fe4S_Fe_S_CS.

IPR013785, Aldolase_TIM.

IPR005720, Dihydroorotate_DH_1.

IPR012135, Dihydroorotate_DH_1_2.

IPR012285, Fum_reductase_C.

IPR009051, Helical_ferredxn.

IPR023753, Pyr_nucl-diS_OxRdtase_FAD/NAD.
Gene3D

G3DSA:3.20.20.70, Aldolase_TIM; 1.

G3DSA:1.10.1060.10, Fum_reductase_C; 1.
PANTHER
Pfam

PF01180, DHO_dh; 1.

PF07992, Pyr_redox_2; 1.
PRINTS
SUPFAM

SSF46548, Helical_ferredxn; 1.
PROSITE

PS00198, 4FE4S_FER_1; 1.

PS51379, 4FE4S_FER_2; 3.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Polypeptide chain 1 - 1025 1025 Dihydropyrimidine dehydrogenase [NADP+]. /FTId=PRO_0000327502.
Domain 69 - 100 32 4Fe-4S ferredoxin-type 1.
Domain 944 - 976 33 4Fe-4S ferredoxin-type 2.
Domain 978 - 1007 30 4Fe-4S ferredoxin-type 3.
Metal ion 953 1 Iron-sulfur 1 (4Fe-4S) (Potential).
Metal ion 956 1 Iron-sulfur 1 (4Fe-4S) (Potential).
Metal ion 959 1 Iron-sulfur 1 (4Fe-4S) (Potential).
Metal ion 963 1 Iron-sulfur 1 (4Fe-4S) (Potential).
Metal ion 986 1 Iron-sulfur 2 (4Fe-4S) (Potential).
Metal ion 989 1 Iron-sulfur 2 (4Fe-4S) (Potential).
Metal ion 992 1 Iron-sulfur 2 (4Fe-4S) (Potential).
Metal ion 996 1 Iron-sulfur 2 (4Fe-4S) (Potential).
Posttranslational modification of a residue 384 1 N6-acetyllysine (By similarity).
Posttranslational modification of a residue 577 1 Phosphoserine (By similarity).
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

O89000
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG004351
InParanoid

O89000
OMA
OrthoDB
Proteomics
Database (PRIDE)

O89000
Comparative
Toxicogenomics
Database (CTD)

1806
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