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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
FEZ1_HUMAN, Homo sapiens (human) FEZ1 Zygin-1 Functions
wild_type
Starting from $1600,
4 weeks
Protein Domains
mutant
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Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Fasciculation and elongation protein zeta-1;
Alternative name(s):
 Zygin I
Zygin-1
Protein IDs
(Accession numbers)
UniProtKB
 Q99689
NCBI RefSeq

NP_005094.1, NM_005103.4.

NP_072043.1, NM_022549.3.
Organism
Latin Name/
(Common Name)
Homo sapiens (Human).
Taxonomic Identifier (NCBI)
 9606
Gene Names
 FEZ1 [GenPool]
GeneID

9638
Genome
Annotation (Ensembl)

ENST00000278919, ENSP00000278919; ENSG00000149557
Protein Sequence
 
SEQUENCE   392 AA;  45119 MW;  4226ED5EA17706F2 CRC64;
MEAPLVSLDE EFEDLRPSCS EDPEEKPQCF YGSSPHHLED PSLSELENFS SEIISFKSME
DLVNEFDEKL NVCFRNYNAK TENLAPVKNQ LQIQEEEETL QDEEVWDALT DNYIPSLSED
WRDPNIEALN GNCSDTEIHE KEEEEFNEKS ENDSGINEEP LLTADQVIEE IEEMMQNSPD
PEEEEEVLEE EDGGETSSQA DSVLLQEMQA LTQTFNNNWS YEGLRHMSGS ELTELLDQVE
GAIRDFSEEL VQQLARRDEL EFEKEVKNSF ITVLIEVQNK QKEQRELMKK RRKEKGLSLQ
SSRIEKGNQM PLKRFSMEGI SNILQSGIRQ TFGSSGTDKQ YLNTVIPYEK KASPPSVEDL
QMLTNILFAM KEDNEKVPTL LTDYILKVLC PT
General annotation
Function
 May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules.
Cofactor
Subunit structure
 Homodimer; difulfide-linked. May form heterodimers with FEZ2. Interacts with the NH2-terminal variable region (V1) of PKC zeta and weakly with that of PKC epsilon (By similarity). Interacts with UBE4B. Interacts with SAP30L. Interacts with SCOC.
Subcellular location

Cytoplasm, cytoskeleton, centrosome. Cell membrane (By similarity). Note=Co-localizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity).
Tissue specificity
 Mainly expressed in brain.
Induction
Domain
Post-translational modification

Phosphorylated by protein kinase C zeta; which enhancesinteraction with UBE4B and polyubiquitination.

Polyubiquitinated in a UBE4B-dependent manner; which does notlead to proteasomal degradation and may be important forneurogenic activity. Polyubiquitin linkage seems to be mainlythrough Lys-26.
Involvement in disease

References

  • "The Caenorhabditis elegans gene unc-76 and its human homologs definea new gene family involved in axonal outgrowth and fasciculation.";,Bloom L., Horvitz H.R.;,Proc. Natl. Acad. Sci. U.S.A. 94:3414-3419(1997)., PubMeb:9096408 DOI:10.1073/pnas.94.7.3414

  • "Zigins: a family of synaptotagmin-interacting proteins related tounc-76.";,Sugita S., von Poser C., Rosahl T.W., Hata Y., Suedhof T.C.;,Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.

  • "Cloning of human full open reading frames in Gateway(TM) system entryvector (pDONR201).";,Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;,Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

  • "Cloning of human full open reading frames in Gateway(TM) system entryvector (pDONR201).";,Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S.,Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W.,Korn B., Zuo D., Hu Y., LaBaer J.;,Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.

  • "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

  • "Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4Bcontributes to neuritogenesis.";,Okumura F., Hatakeyama S., Matsumoto M., Kamura T., Nakayama K.;,J. Biol. Chem. 279:53533-53543(2004).,PubMeb:15466860 DOI:10.1074/jbc.M402916200

  • "FEZ1 dimerization and interaction with transcription regulatoryproteins involves its coiled-coil region.";,Assmann E.M., Alborghetti M.R., Camargo M.E., Kobarg J.;,J. Biol. Chem. 281:9869-9881(2006).,PubMeb:16484223 DOI:10.1074/jbc.M513280200

  • "Over-expression of GFP-FEZ1 causes generation of multi-lobulatednuclei mediated by microtubules in HEK293 cells.";,Lanza D.C., Trindade D.M., Assmann E.M., Kobarg J.;,Exp. Cell Res. 314:2028-2039(2008).,PubMeb:18439996 DOI:10.1016/j.yexcr.2008.02.012

  • "Human FEZ1 protein forms a disulfide bond mediated dimer:implications for cargo transport.";,Alborghetti M.R., Furlan A.S., Silva J.C., Paes Leme A.F.,Torriani I.C., Kobarg J.;,J. Proteome Res. 9:4595-4603(2010).,PubMeb:20812761 DOI:10.1021/pr100314q

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
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Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR011680, FEZ.
Gene3D
PANTHER

PTHR12394, FEZ; 1.
Pfam

PF07763, FEZ; 1.
PRINTS
SUPFAM
PROSITE
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Polypeptide chain 1 - 392 392 Fasciculation and elongation protein /FTId=PRO_0000189525.
Coiled-coil region 230 - 298 69 Potential.
Compositionally biased region 95 - 98 4 Poly-Glu.
Compositionally biased region 140 - 145 6 Poly-Glu.
Compositionally biased region 182 - 186 5 Poly-Glu.
Posttranslational modification of a residue 58 1 Phosphoserine (By similarity).
Posttranslational modification of a residue 316 1 Phosphoserine (By similarity).
Disulfide bond 133 1 Interchain.
Natural variance 105 - 392 288 Missing (in isoform Short). /FTId=VSP_006951.
Natural variance 123 1 D -> E (in dbSNP:rs597570). /FTId=VAR_020461.
Protein-protein
Interaction
Databases
DIP
IntAct

Q99689
MINT

MINT-1403506
STRING

Q99689
Binary Interactions
With
Entry
#Exp.
IntAct
HTTP42858 1EBI-396435, EBI-466029
KIAA1377Q9P2H0 1EBI-396435, EBI-473176
NEK1Q96PY6 1EBI-396435, EBI-373615
TXNDC9O14530 1EBI-396435, EBI-707554
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG005657
InParanoid
OMA

MEAPLVC
OrthoDB

EOG4SF967
Proteomics
Database (PRIDE)

Q99689
Comparative
Toxicogenomics
Database (CTD)

9638
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Email: [email protected]
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262