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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
GBRB1_BOVIN, Bos taurus (cattle) GABRB1 GABA(A) receptor subunit beta-1 Functions
wild_type
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Protein Domains
mutant
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Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Gamma-aminobutyric acid receptor subunit beta-1;
Alternative name(s):
 GABA(A) receptor subunit beta-1
Protein IDs
(Accession numbers)
UniProtKB
 P08220
NCBI RefSeq

NP_776969.1, NM_174544.2.
Organism
Latin Name/
(Common Name)
Bos taurus (Bovine).
Taxonomic Identifier (NCBI)
 9913
Gene Names
 GABRB1 [GenPool]
GeneID

282239
Genome
Annotation (Ensembl)

ENSBTAT00000023711, ENSBTAP00000023711; ENSBTAG00000017837
Protein Sequence
 
SEQUENCE   474 AA;  54130 MW;  001AE6F7ACEC74C0 CRC64;
MWTVQNRESL GLLSFPVMIA MVCCAHSANE PSNMSYVKET VDRLLKGYDI RLRPDFGGPP
VDVGMRIDVA SIDMVSEVNM DYTLTMYFQQ SWKDKRLSYS GIPLNLTLDN RVADQLWVPD
TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE
SYGYTTDDIE FYWNGGEGAV TGVNKIELPQ FSIVDYKMVS KKVEFTTGAY PRLSLSFRLK
RNIGYFILQT YMPSTLITIL SWVSFWINYD ASAARVALGI TTVLTMTTIS THLRETLPKI
PYVKAIDIYL MGCFVFVFLA LLEYAFVNYI FFGKGPQKKG AGKQDQSANE KNKLEMNKVQ
VDAHGNILLS TLEIRNETSG SEVLTGVGDP KTTMYSYDSA SIQYRKPMSS REGYGRALDR
HGAHSKGRIR RRASQLKVKI PDLTDVNSID KWSRMFFPIT FSLFNVVYWL YYVH
General annotation
Function
 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Cofactor
Subunit structure
 Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity).
Subcellular location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue specificity
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "Sequence and functional expression of the GABA A receptor shows aligand-gated receptor super-family.";,Schofield P.R., Darlison M.G., Fujita N., Burt D.R., Stephenson F.A.,Rodriguez H., Rhee L.M., Ramachandran J., Reale V., Glencorse T.A.,Seeburg P.H., Barnard E.A.;,Nature 328:221-227(1987)., PubMeb:3037384 DOI:10.1038/328221a0

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR006028, GABAA_rcpt.

IPR002289, GABAAb_rcpt.

IPR006202, Neur_chan_lig-bd.

IPR006201, Neur_channel.

IPR006029, Neurotrans-gated_channel_TM.

IPR018000, Neurotransmitter_ion_chnl_CS.
Gene3D

G3DSA:2.70.170.10, Neur_chan_lig_bd; 1.
PANTHER

PTHR18945, Neur_channel; 1.
Pfam

PF02931, Neur_chan_LBD; 1.

PF02932, Neur_chan_memb; 1.
PRINTS

PR01160, GABAARBETA.

PR00253, GABAARECEPTR.

PR00252, NRIONCHANNEL.
SUPFAM

SSF90112, Neu_channel_TM; 1.

SSF63712, Neur_chan_LBD; 1.
PROSITE

PS00236, NEUROTR_ION_CHANNEL; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Signal sequence 1 - 25 25 Potential.
Polypeptide chain 26 - 474 449 Gamma-aminobutyric acid receptor subunit /FTId=PRO_0000000455.
Topological domain 26 - 245 220 Extracellular (Probable).
Topological domain 328 - 451 124 Cytoplasmic (Probable).
Transmembrane region 246 - 267 22 Helical; (Probable).
Transmembrane region 271 - 293 23 Helical; (Probable).
Transmembrane region 305 - 327 23 Helical; (Probable).
Transmembrane region 452 - 473 22 Helical; (Probable).
Posttranslational modification of a residue 448 1 Phosphoserine (By similarity).
Glycosylation site 33 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 105 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 174 1 N-linked (GlcNAc...) (Potential).
Disulfide bond 161 - 175 15 By similarity.
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG051707
InParanoid

P08220
OMA

SIQYRRP
OrthoDB

EOG45756F
Proteomics
Database (PRIDE)

P08220
Comparative
Toxicogenomics
Database (CTD)

2560
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