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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
GBRB1_RAT, Rattus norvegicus (Norway rat) Gabrb1 GABA(A) receptor subunit beta-1 Functions
wild_type
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Protein Domains
mutant
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Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Gamma-aminobutyric acid receptor subunit beta-1;
Alternative name(s):
 GABA(A) receptor subunit beta-1
Protein IDs
(Accession numbers)
UniProtKB
 P15431
NCBI RefSeq

NP_037088.1, NM_012956.1.
Organism
Latin Name/
(Common Name)
Rattus norvegicus (Rat).
Taxonomic Identifier (NCBI)
 10116
Gene Names
 Gabrb1 [GenPool]
GeneID

25450
Genome
Annotation (Ensembl)

ENSRNOT00000003170, ENSRNOP00000003170; ENSRNOG00000002327
Protein Sequence
 
SEQUENCE   474 AA;  54072 MW;  986277FDBD66377A CRC64;
MWTVQNRESL GLLSFPVMVA MVCCAHSSNE PSNMSYVKET VDRLLKGYDI RLRPDFGGPP
VDVGMRIDVA SIDMVSEVNM DYTLTMYFQQ SWKDKRLSYS GIPLNLTLDN RVADQLWVPD
TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE
SYGYTTDDIE FYWNGGEGAV TGVNKIELPQ FSIVDYKMVS KKVEFTTGAY PRLSLSFRLK
RNIGYFILQT YMPSTLITIL SWVSFWINYD ASAARVALGI TTVLTMTTIS THLRETLPKI
PYVKAIDIYL MGCFVFVFLA LLEYAFVNYI FFGKGPQKKG ASKQDQSANE KNKLEMNKVQ
VDAHGNILLS TLEIRNETSG SEVLTGVSDP KATMYSYDSA SIQYRKPLSS REGFGRGLDR
HGVPGKGRIR RRASQLKVKI PDLTDVNSID KWSRMFFPIT FSLFNVVYWL YYVH
General annotation
Function
 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Cofactor
Subunit structure
 Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity).
Subcellular location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Tissue specificity
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "GABAA receptor beta subunit heterogeneity: functional expression ofcloned cDNAs.";,Ymer S., Schofield P.R., Draguhn A., Werner P., Koehler M.,Seeburg P.H.;,EMBO J. 8:1665-1670(1989)., PubMeb:2548852

  • "GABAA-receptor expressed from rat brain alpha- and beta-subunit cDNAsdisplays potentiation by benzodiazepine receptor ligands.";,Malherbe P., Draguhn A., Multhaup G., Beyreuther K., Mohler H.;,Brain Res. Mol. Brain Res. 8:199-208(1990)., PubMeb:1977069 DOI:10.1016/0169-328X(90)90017-8

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR006028, GABAA_rcpt.

IPR002289, GABAAb_rcpt.

IPR006202, Neur_chan_lig-bd.

IPR006201, Neur_channel.

IPR006029, Neurotrans-gated_channel_TM.

IPR018000, Neurotransmitter_ion_chnl_CS.
Gene3D

G3DSA:2.70.170.10, Neur_chan_lig_bd; 1.
PANTHER

PTHR18945, Neur_channel; 1.
Pfam

PF02931, Neur_chan_LBD; 1.

PF02932, Neur_chan_memb; 1.
PRINTS

PR01160, GABAARBETA.

PR00253, GABAARECEPTR.

PR00252, NRIONCHANNEL.
SUPFAM

SSF90112, Neu_channel_TM; 1.

SSF63712, Neur_chan_LBD; 1.
PROSITE

PS00236, NEUROTR_ION_CHANNEL; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Signal sequence 1 - 25 25 Potential.
Polypeptide chain 26 - 474 449 Gamma-aminobutyric acid receptor subunit /FTId=PRO_0000000458.
Topological domain 26 - 245 220 Extracellular (Probable).
Topological domain 328 - 451 124 Cytoplasmic (Probable).
Transmembrane region 246 - 267 22 Helical; (Probable).
Transmembrane region 271 - 293 23 Helical; (Probable).
Transmembrane region 305 - 327 23 Helical; (Probable).
Transmembrane region 452 - 473 22 Helical; (Probable).
Posttranslational modification of a residue 448 1 Phosphoserine (By similarity).
Glycosylation site 33 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 105 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 174 1 N-linked (GlcNAc...) (Potential).
Disulfide bond 161 - 175 15 By similarity.
Different sources report differing sequences 420 1 R -> Q (in Ref. 2; no nucleotide entry).
Different sources report differing sequences 428 1 R -> P (in Ref. 2; no nucleotide entry).
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG051707
InParanoid

P15431
OMA

SIQYRRP
OrthoDB

EOG45756F
Proteomics
Database (PRIDE)
Comparative
Toxicogenomics
Database (CTD)

2560
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Email: [email protected]
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262