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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
GILT_RAT, Rattus norvegicus (Norway rat) Ifi30 Interferon gamma inducible protein 30 Functions
wild_type
Starting from $1600,
4 weeks
Protein Domains
mutant
Quote

Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Gamma-interferon-inducible lysosomal thiol reductase;
Alternative name(s):
 Interferon gamma inducible protein 30
Protein IDs
(Accession numbers)
UniProtKB
 Q499T2
NCBI RefSeq

NP_001025197.1, NM_001030026.1.
Organism
Latin Name/
(Common Name)
Rattus norvegicus (Rat).
Taxonomic Identifier (NCBI)
 10116
Gene Names
 Ifi30 [GenPool]
GeneID

290644
Genome
Annotation (Ensembl)

ENSRNOT00000026225, ENSRNOP00000026225; ENSRNOG00000019387
Protein Sequence
 
SEQUENCE   248 AA;  27644 MW;  12A82B9AF6E2E3B4 CRC64;
MSCSPLVPFL SLLLLLFLPE VPRAATASLP QGSSEGAATC KAHDLCLFGP RRLLSAPPVN
VSLYYESLCG ACRYFLVRNL FPTWLMVMEI MNITLVPYGN AQERNVSGTW EFTCQHGELE
CKLNKVEACL LDKLEKEAAF LTIVCMEEME DMEKKLGPCL QLYVPEVSPE SIMECATGKR
GTELMHENAQ LTDALQPPHE YVPWVLVNEK PLTDPSQLLS SVCELYQGTE KPDICSSMAD
APREVCYK
General annotation
Function
 Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II- restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds. Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T cells or crosspresentation (By similarity).
Cofactor
Subunit structure
 Dimer; disulfide-linked (By similarity).
Subcellular location

Secreted (By similarity). Lysosome (By similarity).
Tissue specificity
Induction
Domain
Post-translational modification

N-glycosylated. Sugar chains contain mannose-6-phosphate (Bysimilarity).

Synthesized as a 35 kDa precursor which is then processedinto the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated bymultiple lysosomal proteases (By similarity).
Involvement in disease

References

  • Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;,Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.

  • "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR004911, Interferon-induced_GILT.
Gene3D
PANTHER

PTHR13234, GILT; 1.
Pfam

PF03227, GILT; 1.
PRINTS
SUPFAM
PROSITE
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Signal sequence 1 - 24 24 Potential.
Propeptide 25 - 54 30 Removed in mature form (By similarity). /FTId=PRO_0000406227.
Propeptide 231 - 248 18 Removed in mature form (By similarity). /FTId=PRO_0000406229.
Polypeptide chain 55 - 230 176 Gamma-interferon-inducible lysosomal /FTId=PRO_0000406228.
Glycosylation site 60 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 92 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 105 1 N-linked (GlcNAc...) (Potential).
Disulfide bond 69 - 72 4 Redox-active (By similarity).
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

Q499T2
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG005837
InParanoid

Q499T2
OMA

QPPHEYV
OrthoDB

EOG94TRV3
Proteomics
Database (PRIDE)
Comparative
Toxicogenomics
Database (CTD)

10437
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Email: [email protected]
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262