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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
GLP1R_RAT, Rattus norvegicus (Norway rat) Glp1r Glucagon-like peptide 1 receptor Functions
wild_type
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Protein Domains
mutant
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Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Glucagon-like peptide 1 receptor;
Alternative name(s):
Protein IDs
(Accession numbers)
UniProtKB
 P32301
NCBI RefSeq

NP_036860.1, NM_012728.1.
Organism
Latin Name/
(Common Name)
Rattus norvegicus (Rat).
Taxonomic Identifier (NCBI)
 10116
Gene Names
 Glp1r [GenPool]
GeneID

25051
Genome
Annotation (Ensembl)
Protein Sequence
 
SEQUENCE   463 AA;  52877 MW;  ABE2183E8EBE621F CRC64;
MAVTPSLLRL ALLLLGAVGR AGPRPQGATV SLSETVQKWR EYRHQCQRFL TEAPLLATGL
FCNRTFDDYA CWPDGPPGSF VNVSCPWYLP WASSVLQGHV YRFCTAEGIW LHKDNSSLPW
RDLSECEESK QGERNSPEEQ LLSLYIIYTV GYALSFSALV IASAILVSFR HLHCTRNYIH
LNLFASFILR ALSVFIKDAA LKWMYSTAAQ QHQWDGLLSY QDSLGCRLVF LLMQYCVAAN
YYWLLVEGVY LYTLLAFSVF SEQRIFKLYL SIGWGVPLLF VIPWGIVKYL YEDEGCWTRN
SNMNYWLIIR LPILFAIGVN FLVFIRVICI VIAKLKANLM CKTDIKCRLA KSTLTLIPLL
GTHEVIFAFV MDEHARGTLR FVKLFTELSF TSFQGFMVAV LYCFVNNEVQ MEFRKSWERW
RLERLNIQRD SSMKPLKCPT SSVSSGATVG SSVYAATCQN SCS
General annotation
Function
 This is a receptor for glucagon-like peptide 1. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
Cofactor
Subunit structure
Subcellular location

Cell membrane; Multi-pass membrane protein.
Tissue specificity
 Pancreatic islets, stomach, lung, rat insulinoma cell line.
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "Expression cloning of the pancreatic beta cell receptor for thegluco-incretin hormone glucagon-like peptide 1.";,Thorens B.;,Proc. Natl. Acad. Sci. U.S.A. 89:8641-8645(1992)., PubMeb:1326760 DOI:10.1073/pnas.89.18.8641

  • "Molecular cloning of a cDNA encoding for the GLP-1 receptor expressedin rat lung.";,Lankat-Buttgereit B., Goke R., Fehmann H.C., Richter G., Goke B.;,Exp. Clin. Endocrinol. 102:341-347(1994)., PubMeb:7813606

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
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Protein Domain Databases
InterPro

IPR017981, GPCR_2-like.

IPR001879, GPCR_2_extracellular_dom.

IPR003290, GPCR_2_GLP1/glucagon_rcpt.

IPR003292, GPCR_2_GLP1_rcpt.

IPR000832, GPCR_2_secretin-like.

IPR017983, GPCR_2_secretin-like_CS.
Gene3D
PANTHER

PTHR12011:SF20, Glucgn_like_pep_1_rcpt; 1.
Pfam

PF00002, 7tm_2; 1.

PF02793, HRM; 1.
PRINTS

PR01353, GLUCAGNFAMLY.

PR01355, GLUCAGNLIKER.

PR00249, GPCRSECRETIN.
SUPFAM
PROSITE

PS00649, G_PROTEIN_RECEP_F2_1; 1.

PS00650, G_PROTEIN_RECEP_F2_2; 1.

PS50227, G_PROTEIN_RECEP_F2_3; 1.

PS50261, G_PROTEIN_RECEP_F2_4; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Signal sequence 1 - 21 21 Potential.
Polypeptide chain 22 - 463 442 Glucagon-like peptide 1 receptor. /FTId=PRO_0000012837.
Topological domain 22 - 145 124 Extracellular (Potential).
Topological domain 169 - 176 8 Cytoplasmic (Potential).
Topological domain 197 - 227 31 Extracellular (Potential).
Topological domain 253 - 264 12 Cytoplasmic (Potential).
Topological domain 289 - 303 15 Extracellular (Potential).
Topological domain 330 - 351 22 Cytoplasmic (Potential).
Topological domain 373 - 387 15 Extracellular (Potential).
Topological domain 409 - 463 55 Cytoplasmic (Potential).
Transmembrane region 146 - 168 23 Helical; Name=1; (Potential).
Transmembrane region 177 - 196 20 Helical; Name=2; (Potential).
Transmembrane region 228 - 252 25 Helical; Name=3; (Potential).
Transmembrane region 265 - 288 24 Helical; Name=4; (Potential).
Transmembrane region 304 - 329 26 Helical; Name=5; (Potential).
Transmembrane region 352 - 372 21 Helical; Name=6; (Potential).
Transmembrane region 388 - 408 21 Helical; Name=7; (Potential).
Glycosylation site 63 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 82 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 115 1 N-linked (GlcNAc...) (Potential).
Disulfide bond 46 - 71 26 By similarity.
Disulfide bond 62 - 104 43 By similarity.
Disulfide bond 85 - 126 42 By similarity.
Disulfide bond 226 - 296 71 By similarity.
Different sources report differing sequences 323 1 V -> I (in Ref. 2; AAP31860).
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

P32301
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG008318
InParanoid

P32301
OMA
OrthoDB
Proteomics
Database (PRIDE)

P32301
Comparative
Toxicogenomics
Database (CTD)

2740
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Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
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