Protein Annotations for Homeobox protein Hox-1.4, HXA4

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Name	Gene Symbol	Rec Full Name	Protein Information	Quick Quote	Price, Turnaround
HXA4_CHICK, Gallus gallus (chicken)	HOXA4	Homeobox protein Hox-1.4	Functions		Starting from $1600, 4 weeks
HXA4_CHICK, Gallus gallus (chicken)	HOXA4	Homeobox protein Hox-1.4	Protein Domains		Quote

Protein Names

Recommended name:	Homeobox protein Hox-A4;
Alternative name(s):	Homeobox protein Hox-1.4

Protein IDs
(Accession numbers)

UniProtKB	P17277
NCBI RefSeq	NP_001025517.1, NM_001030346.1.

Organism

Latin Name/ (Common Name)	Gallus gallus (Chicken).
Taxonomic Identifier (NCBI)	9031

Gene Names

HOXA4 [GenPool]

GeneID

395307

Genome
Annotation (Ensembl)

Protein Sequence

SEQUENCE   309 AA;  33478 MW;  8898A41502319341 CRC64;
MTMSSFLINS NYIEPKFPPC EEYTQHSGSA GSSASYHPHH PHPHAPPPPP PPPPPHLHAA
HPGPALPEYF PRPRREPGYQ APAAPPGPPG PPPEALYPAQ APSYPQAPYS YSSAGSAAPG
PEQPPPGASP PPPPPAKGHP GPAQPLLPGH ALQRRCEAAP AAGAGTGPGC ALLPDKSLPG
LKGKEPVVYP WMKKIHVSTV NPNYSGGEPK RSRTAYTRQQ VLELEKEFHF NRYLTRRRRI
EIAHTLCLSE RQVKIWFQNR RMKWKKDHKL PNTKMRSSNQ PSLGQQQAKA QTQGHPRPLD
GAAPNAAAL

General annotation

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to sites in the 5'-flanking sequence of its coding region with various affinities. The consensus sequences of the high and low affinity binding sites are 5'-TAATGA[CG]-3' and 5'-CTAATTTT- 3'.
Cofactor
Subunit structure
Subcellular location	Nucleus.
Tissue specificity
Induction
Domain	The proline stretch works as a part of the transcriptional activation domain.
Post-translational modification
Involvement in disease

References

"Specific DNA binding of the two chicken Deformed family homeodomainproteins, Chox-1.4 and Chox-a.";,Sasaki H., Yokoyama E., Kuroiwa A.;,Nucleic Acids Res. 18:1739-1747(1990)., PubMeb:1970866 DOI:10.1093/nar/18.7.1739
"Isolation and analysis of chick homeobox cDNA clones.";,Scotting P.J., Hewitt M., Keynes R.J.;,Nucleic Acids Res. 18:3999-3999(1990)., PubMeb:1973835 DOI:10.1093/nar/18.13.3999

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Gene & Protein

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Protein Domain Databases

InterPro	IPR001356, Homeobox. IPR001827, Homeobox_Antennapedia_CS. IPR017970, Homeobox_CS. IPR020479, Homeobox_eu. IPR009057, Homeodomain-like. IPR012287, Homeodomain-rel.
Gene3D	G3DSA:1.10.10.60, Homeodomain-rel; 1.
PANTHER
Pfam	PF00046, Homeobox; 1.
PRINTS	PR00024, HOMEOBOX.
SUPFAM	SSF46689, Homeodomain_like; 1.
PROSITE	PS00032, ANTENNAPEDIA; 1. PS00027, HOMEOBOX_1; 1. PS50071, HOMEOBOX_2; 1.

3D Structure
Database (PDB)

Entry

Method

Resolution (A)

Chain

Positions

PDBsum

Sequence
Annotation

Feature key	Position(s)	Length	Description
Polypeptide chain	1 - 309	309	Homeobox protein Hox-A4. /FTId=PRO_0000200052.
DNA-binding region	209 - 268	60	Homeobox.
Sequence motif	188 - 193	6	Antp-type hexapeptide.
Compositionally biased region	38 - 148	111	Pro-rich.

Protein-protein
Interaction
Databases

DIP
IntAct
MINT
STRING

Binary Interactions

With

Entry

#Exp.

IntAct

Enzyme and Pathway Databases

Pathway Interaction DB
Reactome

Phylogenomic Database

HOVERGEN	HBG016849
InParanoid	P17277
OMA
OrthoDB	EOG4GTKF7

Proteomics
Database (PRIDE)

Comparative
Toxicogenomics
Database (CTD)

3201

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