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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
I22R2_MOUSE, Mus musculus (house mouse) Il22ra2 ZcytoR16 Functions
wild_type
Starting from $1600,
4 weeks
Protein Domains
mutant
Quote

Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Interleukin-22 receptor subunit alpha-2;
Alternative name(s):
 Cytokine receptor family type 2, soluble 1
Interleukin-22-binding protein
ZcytoR16
Protein IDs
(Accession numbers)
UniProtKB
 Q80XF5
NCBI RefSeq

NP_839989.2, NM_178258.5.
Organism
Latin Name/
(Common Name)
Mus musculus (Mouse).
Taxonomic Identifier (NCBI)
 10090
Gene Names
 Il22ra2 [GenPool]
GeneID

237310
Genome
Annotation (Ensembl)
Protein Sequence
 
SEQUENCE   230 AA;  26589 MW;  9AEA29768A756A75 CRC64;
MMPKHCLLGL LIILLSSATE IQPARVSLTP QKVRFQSRNF HNILHWQAGS SLPSNNSIYF
VQYKMYGQSQ WEDKVDCWGT TALFCDLTNE TLDPYELYYG RVMTACAGRH SAWTRTPRFT
PWWETKLDPP VVTITRVNAS LRVLLRPPDL PNRNQSGKNA SMETYYGLVY RVFTINNSLE
KEQKAYEGTQ RAVEIEGLIP HSSYCVVAEM YQPMFDRRSP RSKERCVQIP
General annotation
Function
 Receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.
Cofactor
Subunit structure
Subcellular location

Secreted.
Tissue specificity
 Highly expressed in lymph nodes and at lower levels in lung, spleen, and thymus. Not expressed in kidney, liver and heart.
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "Cloning and characterization of mouse IL-22 binding protein.";,Wei C.-C., Ho T.-W., Liang W.-G., Chen G.-Y., Chang M.-S.;,Genes Immun. 4:204-211(2003)., PubMeb:12700595 DOI:10.1038/sj.gene.6363947

  • "Cloning of murine IL-22 receptor alpha 2 and comparison with itshuman counterpart.";,Weiss B., Wolk K., Gruenberg B.H., Volk H.D., Sterry W., Asadullah K.,Sabat R.;,Genes Immun. 5:330-336(2004).,PubMeb:15201862 DOI:10.1038/sj.gene.6364104

  • "Crystal structure of a soluble decoy receptor IL-22BP bound tointerleukin-22.";,de Moura P.R., Watanabe L., Bleicher L., Colau D., Dumoutier L.,Lemaire M.M., Renauld J.C., Polikarpov I.;,FEBS Lett. 583:1072-1077(2009).,PubMeb:19285080 DOI:10.1016/j.febslet.2009.03.006

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR008957, Fibronectin_III_dom.

IPR013783, Ig-like_fold.

IPR015373, Interferon_alpha/beta_rcpt_bsu.
Gene3D

G3DSA:2.60.40.10, Ig-like_fold; 1.
PANTHER
Pfam

PF09294, Interfer-bind; 1.
PRINTS
SUPFAM

SSF49265, FN_III-like; 2.
PROSITE

PS50853, FN3; FALSE_NEG.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Signal sequence 1 - 20 20 By similarity.
Polypeptide chain 21 - 230 210 Interleukin-22 receptor subunit alpha-2. /FTId=PRO_0000011017.
Domain 30 - 128 99 Fibronectin type-III 1.
Domain 129 - 230 102 Fibronectin type-III 2.
Site 66 1 Critical for IL22-binding.
Site 118 1 Critical for IL22-binding.
Disulfide bond 205 - 226 22 By similarity.
Mutagenesis 66 1 Y->A: Abolishes IL22-binding.
Mutagenesis 118 1 R->A: Abolishes IL22-binding.
Different sources report differing sequences 149 1 D -> E (in Ref. 2; CAD88474).
Different sources report differing sequences 228 1 Q -> H (in Ref. 2; CAD88474).
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

Q80XF5
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG052067
InParanoid
OMA
OrthoDB

EOG4RR6JV
Proteomics
Database (PRIDE)

Q80XF5
Comparative
Toxicogenomics
Database (CTD)

116379
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Email: [email protected]
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262