• English
  • Sign In
    Please Sign In
    Sign In
    New to GenScript?
    Register
  • Contact Us
×
Contact us now: +1-877-436-7274
Recombinant Protein & rAb Services
24 hour
Home » Recombinant Protein & rAb Services » PROTBANK™ Protein Database
Email to GenScript

Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

  • THAT AND
  • THAT AND

Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
ITAV_CHICK, Gallus gallus (chicken) ITGAV Vitronectin receptor subunit alpha Functions
wild_type
Quote
Protein Domains
mutant
Quote

Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Integrin alpha-V;
Alternative name(s):
 Vitronectin receptor subunit alpha
Integrin alpha-V heavy chain
Integrin alpha-V light chain
Protein IDs
(Accession numbers)
UniProtKB
 P26008
NCBI RefSeq

NP_990770.1, NM_205439.1.
Organism
Latin Name/
(Common Name)
Gallus gallus (Chicken).
Taxonomic Identifier (NCBI)
 9031
Gene Names
 ITGAV [GenPool]
GeneID

396420
Genome
Annotation (Ensembl)
Protein Sequence
 
SEQUENCE   1034 AA;  114389 MW;  D76B0B8A692DC684 CRC64;
MAALRASLLL SCALTAARAF NLDAERPAVY SGAEGSYFGF AVDFFAPDAS SMFLLVGAPK
ANTSQSNVVE GGQVLQCNWN SNRNCQPIIF DSTGNRDFAP DDPLEFKSHQ WFGASVRSKN
DKILACAPLY HWRTETKQER EPVGTCYLFD GSKSVEYAPC RSTTIDADGQ GFCQGGFSID
FTKGDRVLLG GPGSFYWQGQ LISDRVAEIL AKYDSKVYST KYDDQLATRP ASAAFDDSYL
GYSVAVGDFS GDGIEDFVSG VPRAARTLGM VSIYNGKNMS SMYNFTGEQM AAYFGYSVAT
TDINGDDYTD LFIGAPLFMD RGSDGKLQEV GQVSICLQRA SGGFQIAKLN GFEIFARFGS
AIAPLGDLDQ DGFNDIAVAA PYGGEDKRGL VYIYNGRATG LNAVPSRILE GQWAARTMPP
SFGYSLKGAT DVDKNGYPDL IVGAFGVDTA VLYRARPVIR VNAALEVNPT ILNPENKACS
LADVKVSCFK VKFCLKADGK GKLPNSLNFQ VELLLDKLKQ KGAIRRALFL HSKQPSHSKN
MTITKGGKMN CEELDAFLRD ESEFRDKLTP ITIFMEYRLD YKTAVDATGL HPILNQFIPA
NMSRQAHILL DCGEDNICKP KLEVSVRSDQ KKIYIGDDNP LTLIVTAENQ GEGAYEAELF
VIVPPQADFI GVVRNNEALA RLSCAFKTEN QTRMVVCDLG NPMKAGTKLL AGLRFSVHQQ
SEMDTSVKFD LQIRSSNLFD NLSPVAFYQV DLAISAAVEI RGVSSPDHIF LPIANWQPKE
NPETEDDIGP LVQHIYELRN NGPSAFSKVM MTLQWPYKYK NYTLLYIVQY DIDGPMNCTS
DMEINPLKIK ISAPKEDEKN ETFSREDNRN HRISRRDLTA IEGDVQTLGC GNADCLKIVC
QVGHLERGKS AILYLKSRLW TQTFMNKENQ NHSYSLQSSA SFNVIEFPYK NLSFEDIHNS
TVVTTNITWG IQPQPMPVPV WVIILAVLAG LLLLAVLVLV MYRMGFFKRV RPPQEEQERE
QLQPHENGEG TSEA
General annotation
Function
 The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands.
Cofactor
Subunit structure
 Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8.
Subcellular location

Membrane; Single-pass type I membrane protein.
Tissue specificity
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "Chick integrin alpha V subunit molecular analysis reveals highconservation of structural domains and association with multiple betasubunits in embryo fibroblasts.";,Bossy B., Reichardt L.F.;,Biochemistry 29:10191-10198(1990)., PubMeb:1703004 DOI:10.1021/bi00496a006

Order Custom
Gene & Protein
Secured Online Quotation
Email: [email protected]
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262
Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR013517, FG-GAP.

IPR013519, Int_alpha_beta-p.

IPR000413, Integrin_alpha.

IPR013649, Integrin_alpha-2.

IPR018184, Integrin_alpha_C_CS.
Gene3D
PANTHER
Pfam

PF01839, FG-GAP; 2.

PF00357, Integrin_alpha; 1.

PF08441, Integrin_alpha2; 1.
PRINTS

PR01185, INTEGRINA.
SUPFAM
PROSITE

PS51470, FG_GAP; 7.

PS00242, INTEGRIN_ALPHA; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Signal sequence 1 - 19 19 Potential.
Polypeptide chain 20 - 1034 1015 Integrin alpha-V. /FTId=PRO_0000016307.
Polypeptide chain 20 - 875 856 Integrin alpha-V heavy chain (Potential). /FTId=PRO_0000016308.
Polypeptide chain 877 - 1034 158 Integrin alpha-V light chain (Potential). /FTId=PRO_0000016309.
Topological domain 20 - 978 959 Extracellular (Potential).
Topological domain 1003 - 1034 32 Cytoplasmic (Potential).
Transmembrane region 979 - 1002 24 Helical; (Potential).
Internal sequence repetition 21 - 86 66 FG-GAP 1.
Internal sequence repetition 97 - 158 62 FG-GAP 2.
Internal sequence repetition 161 - 213 53 FG-GAP 3.
Internal sequence repetition 225 - 283 59 FG-GAP 4.
Internal sequence repetition 284 - 345 62 FG-GAP 5.
Internal sequence repetition 346 - 403 58 FG-GAP 6.
Internal sequence repetition 407 - 470 64 FG-GAP 7.
Calcium-binding region 248 - 256 9 Potential.
Calcium-binding region 302 - 310 9 Potential.
Calcium-binding region 367 - 375 9 Potential.
Calcium-binding region 431 - 439 9 Potential.
Sequence motif 1005 - 1009 5 GFFKR motif.
Glycosylation site 62 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 278 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 284 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 540 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 601 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 690 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 821 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 837 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 860 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 931 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 951 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 959 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 966 1 N-linked (GlcNAc...) (Potential).
Disulfide bond 77 - 85 9 By similarity.
Disulfide bond 126 - 146 21 By similarity.
Disulfide bond 160 - 173 14 By similarity.
Disulfide bond 479 - 488 10 By similarity.
Disulfide bond 494 - 551 58 By similarity.
Disulfide bond 612 - 618 7 By similarity.
Disulfide bond 684 - 697 14 By similarity.
Disulfide bond 838 - 890 53 Interchain (between heavy and light
Disulfide bond 895 - 900 6 By similarity.
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

P26008
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG006186
InParanoid

P26008
OMA
OrthoDB

EOG46DM20
Proteomics
Database (PRIDE)
Comparative
Toxicogenomics
Database (CTD)

3685
Order Your Custom Protein
Secured Online Quotation
Email: [email protected]
Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262