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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
KCAB3_HUMAN, Homo sapiens (human) KCNAB3 Kv-beta-3 Functions
wild_type
Starting from $1600,
4 weeks
Protein Domains
mutant
Quote

Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Voltage-gated potassium channel subunit beta-3;
Alternative name(s):
 K(+) channel subunit beta-3
Kv-beta-3
Protein IDs
(Accession numbers)
UniProtKB
 O43448
NCBI RefSeq

NP_004723.2, NM_004732.2.
Organism
Latin Name/
(Common Name)
Homo sapiens (Human).
Taxonomic Identifier (NCBI)
 9606
Gene Names
 KCNAB3 [GenPool]
GeneID

9196
Genome
Annotation (Ensembl)

ENST00000303790, ENSP00000302719; ENSG00000170049
Protein Sequence
 
SEQUENCE   404 AA;  43670 MW;  57C4FAD8D19D9EBB CRC64;
MQVSIACTEQ NLRSRSSEDR LCGPRPGPGG GNGGPAGGGH GNPPGGGGSG PKARAALVPR
PPAPAGALRE STGRGTGMKY RNLGKSGLRV SCLGLGTWVT FGSQISDETA EDVLTVAYEH
GVNLFDTAEV YAAGKAERTL GNILKSKGWR RSSYVITTKI FWGGQAETER GLSRKHIIEG
LRGSLERLQL GYVDIVFANR SDPNCPMEEI VRAMTYVINQ GLALYWGTSR WGAAEIMEAY
SMARQFNLIP PVCEQAEHHL FQREKVEMQL PELYHKIGVG SVTWYPLACG LITSKYDGRV
PDTCRASIKG YQWLKDKVQS EDGKKQQAKV MDLLPVAHQL GCTVAQLAIA WCLRSEGVSS
VLLGVSSAEQ LIEHLGALQV LSQLTPQTVM EIDGLLGNKP HSKK
General annotation
Function
 Accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. Alters the functional properties of Kv1.5.
Cofactor
Subunit structure
 Forms heteromultimeric complex with alpha subunits.
Subcellular location

Cytoplasm (Potential).
Tissue specificity
 Brain specific. Most prominent expression in cerebellum. Weaker signals detected in cortex, occipital lobe, frontal lobe and temporal lobe. Not detected in spinal cord, heart, lung, liver, kidney, pancreas, placenta and skeletal muscle.
Induction
Domain
 Alteration of functional properties of alpha subunit is mediated through N-terminal domain of beta subunit (Probable).
Post-translational modification

Involvement in disease

References

  • "Coexpression of the KCNA3B gene product with Kv1.5 leads to a novelA-type potassium channel.";,Leicher T., Baehring R., Isbrandt D., Pongs O.;,J. Biol. Chem. 273:35095-35101(1998)., PubMeb:9857044 DOI:10.1074/jbc.273.52.35095

  • "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

  • "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";,Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;,Cell 127:635-648(2006).,PubMeb:17081983 DOI:10.1016/j.cell.2006.09.026

  • "Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";,Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;,Science 325:834-840(2009).,PubMeb:19608861 DOI:10.1126/science.1175371

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR001395, Aldo/ket_red.

IPR005983, K_chnl_volt-dep_bsu_KCNAB.

IPR005399, K_chnl_volt-dep_bsu_KCNAB-rel.

IPR005402, K_chnl_volt-dep_bsu_KCNAB3.

IPR023210, NADP_OxRdtase_dom.
Gene3D

G3DSA:3.20.20.100, Aldo/ket_red; 1.
PANTHER

PTHR11732, Aldo/ket_red; 1.

PTHR11732:SF14, KCNAB_channel; 1.
Pfam

PF00248, Aldo_ket_red; 1.
PRINTS

PR01580, KCNAB3CHANEL.

PR01577, KCNABCHANNEL.
SUPFAM

SSF51430, Aldo/ket_red; 1.
PROSITE
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Polypeptide chain 1 - 404 404 Voltage-gated potassium channel subunit /FTId=PRO_0000148750.
Posttranslational modification of a residue 184 1 Phosphoserine.
Posttranslational modification of a residue 315 1 N6-acetyllysine.
Different sources report differing sequences 57 1 L -> V (in Ref. 1; AAB92499).
Different sources report differing sequences 60 1 R -> G (in Ref. 1; AAB92499).
Different sources report differing sequences 65 1 A -> G (in Ref. 1; AAB92499).
Different sources report differing sequences 68 1 L -> V (in Ref. 1; AAB92499).
Different sources report differing sequences 86 - 88 3 SGL -> CGV (in Ref. 1; AAB92499).
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

O43448
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG052216
InParanoid

O43448
OMA

RATIKGY
OrthoDB

EOG476K0F
Proteomics
Database (PRIDE)

O43448
Comparative
Toxicogenomics
Database (CTD)

9196
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Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
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