3778

ENST00000406533, ENSP00000385552; ENSG00000156113

SEQUENCE   1236 AA;  137560 MW;  DF9BFEAF374BE553 CRC64;
MANGGGGGGG SSGGGGGGGG SSLRMSSNIH ANHLSLDASS SSSSSSSSSS SSSSSSSSSS
VHEPKMDALI IPVTMEVPCD SRGQRMWWAF LASSMVTFFG GLFIILLWRT LKYLWTVCCH
CGGKTKEAQK INNGSSQADG TLKPVDEKEE AVAAEVGWMT SVKDWAGVMI SAQTLTGRVL
VVLVFALSIG ALVIYFIDSS NPIESCQNFY KDFTLQIDMA FNVFFLLYFG LRFIAANDKL
WFWLEVNSVV DFFTVPPVFV SVYLNRSWLG LRFLRALRLI QFSEILQFLN ILKTSNSIKL
VNLLSIFIST WLTAAGFIHL VENSGDPWEN FQNNQALTYW ECVYLLMVTM STVGYGDVYA
KTTLGRLFMV FFILGGLAMF ASYVPEIIEL IGNRKKYGGS YSAVSGRKHI VVCGHITLES
VSNFLKDFLH KDRDDVNVEI VFLHNISPNL ELEALFKRHF TQVEFYQGSV LNPHDLARVK
IESADACLIL ANKYCADPDA EDASNIMRVI SIKNYHPKIR IITQMLQYHN KAHLLNIPSW
NWKEGDDAIC LAELKLGFIA QSCLAQGLST MLANLFSMRS FIKIEEDTWQ KYYLEGVSNE
MYTEYLSSAF VGLSFPTVCE LCFVKLKLLM IAIEYKSANR ESRILINPGN HLKIQEGTLG
FFIASDAKEV KRAFFYCKAC HDDITDPKRI KKCGCKRPKM SIYKRMRRAC CFDCGRSERD
CSCMSGRVRG NVDTLERAFP LSSVSVNDCS TSFRAFEDEQ PSTLSPKKKQ RNGGMRNSPN
TSPKLMRHDP LLIPGNDQID NMDSNVKKYD STGMFHWCAP KEIEKVILTR SEAAMTVLSG
HVVVCIFGDV SSALIGLRNL VMPLRASNFH YHELKHIVFV GSIEYLKREW ETLHNFPKVS
ILPGTPLSRA DLRAVNINLC DMCVILSANQ NNIDDTSLQD KECILASLNI KSMQFDDSIG
VLQANSQGFT PPGMDRSSPD NSPVHGMLRQ PSITTGVNIP IITELVNDTN VQFLDQDDDD
DPDTELYLTQ PFACGTAFAV SVLDSLMSAT YFNDNILTLI RTLVTGGATP ELEALIAEEN
ALRGGYSTPQ TLANRDRCRV AQLALLDGPF ADLGDGGCYG DLFCKALKTY NMLCFGIYRL
RDAHLSTPSQ CTKRYVITNP PYEFELVPTD LIFCLMQFDH NAGQSRASLS HSSHSSQSSS
KKSSSVHSIP STANRQNRPK SRESRDKQKY VQEERL

• "Cloning and expression of a human large-conductance calcium-activatedpotassium channel.";,Dworetzky S.I., Trojnacki J.T., Gribkoff V.K.;,Brain Res. Mol. Brain Res. 27:189-193(1994)., PubMeb:7877450 DOI:10.1016/0169-328X(94)90203-8

• "A human calcium-activated potassium channel gene expressed invascular smooth muscle.";,McCobb D.P., Fowler N.L., Featherstone T., Lingle C.J., Saito M.,Krause J.E., Salkoff L.;,Am. J. Physiol. 269:H767-H777(1995)., PubMeb:7573516

• "The DNA sequence and comparative analysis of human chromosome 10.";,Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;,Nature 429:375-381(2004).,PubMeb:15164054 DOI:10.1038/nature02462

• Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,Venter J.C.;,Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

• "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

• "Cloning, expression, and distribution of functionally distinctCa(2+)-activated K+ channel isoforms from human brain.";,Tseng-Crank J., Foster C.D., Krause J.D., Mertz R., Godinot N.,DiChiara T.J., Reinhart P.H.;,Neuron 13:1315-1330(1994)., PubMeb:7993625 DOI:10.1016/0896-6273(94)90418-9

• "Calcium-activated potassium channel expression in human myometrium:effect of pregnancy.";,Mazzone J.N., Kaiser R.A., Buxton I.L.O.;,Proc. West. Pharmacol. Soc. 45:184-186(2002).,PubMeb:12434576

• "BK variant from human heart.";,Naruse K.;,Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.

• "Cloning and characterization of human and mouse homologs of theDrosophila calcium-activated potassium channel gene, slowpoke.";,Pallanck L., Ganetzky B.;,Hum. Mol. Genet. 3:1239-1243(1994)., PubMeb:7987297 DOI:10.1093/hmg/3.8.1239

• "Identification of potassium channels in human lens epithelium.";,Rae J.L., Shepard A.R.;,(In) Civan M.M. (eds.);Current topics in membranes. The eye's aqueous humor - from secretionto glaucoma, pp.45:69-104, Academic Press, San Diego (1998).

• "Characterization of and modulation by a beta-subunit of a human maxiKCa channel cloned from myometrium.";,Wallner M., Meera P., Ottolia M., Kaczorowski G.J., Latorre R.,Garcia M.L., Stefani E., Toro L.;,Recept. Channels 3:185-199(1995)., PubMeb:8821792

• "Cloning and characterization of BKCA alpha subunit from humanpulmonary artery.";,Cairns V.R., Aebly M.R., Rusch N.J.;,Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases.

• "Cloning and characterization of glioma BK, a novel BK channel isoformhighly expressed in human glioma cells.";,Liu X., Chang Y., Reinhart P.H., Sontheimer H., Chang Y.;,J. Neurosci. 22:1840-1849(2002).,PubMeb:11880513

• Liu X., Chang Y., Reinhart P.H., Sontheimer H., Chang Y.;,J. Neurosci. 22:1B-1B(2002).

• "Determinant for beta-subunit regulation in high-conductance voltage-activated and Ca(2+)-sensitive K+ channels: an additionaltransmembrane region at the N-terminus.";,Wallner M., Meera P., Toro L.;,Proc. Natl. Acad. Sci. U.S.A. 93:14922-14927(1996)., PubMeb:8962157 DOI:10.1073/pnas.93.25.14922

• "Large conductance voltage- and calcium-dependent K+ channel, adistinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N-terminus,and an intracellular (S9-S10) C-terminus.";,Meera P., Wallner M., Song M., Toro L.;,Proc. Natl. Acad. Sci. U.S.A. 94:14066-14071(1997)., PubMeb:9391153 DOI:10.1073/pnas.94.25.14066

• "Role of the S4 segment in a voltage-dependent calcium-sensitivepotassium (hSlo) channel.";,Diaz L., Meera P., Amigo J., Stefani E., Alvarez O., Toro L.,Latorre R.;,J. Biol. Chem. 273:32430-32436(1998).,PubMeb:9829973 DOI:10.1074/jbc.273.49.32430

• "Molecular basis of fast inactivation in voltage and Ca2+-activated K+channels: a transmembrane beta-subunit homolog.";,Wallner M., Meera P., Toro L.;,Proc. Natl. Acad. Sci. U.S.A. 96:4137-4142(1999)., PubMeb:10097176 DOI:10.1073/pnas.96.7.4137

• "Cloning and functional characterization of novel large conductancecalcium-activated potassium channel beta subunits, hKCNMB3 andhKCNMB4.";,Brenner R., Jegla T.J., Wickenden A., Liu Y., Aldrich R.W.;,J. Biol. Chem. 275:6453-6461(2000)., PubMeb:10692449 DOI:10.1074/jbc.275.9.6453

• "Identification of a novel tetramerization domain in large conductanceK(ca) channels.";,Quirk J.C., Reinhart P.H.;,Neuron 32:13-23(2001).,PubMeb:11604135 DOI:10.1016/S0896-6273(01)00444-5

• "Consequences of the stoichiometry of Slo1 alpha and auxiliary betasubunits on functional properties of large-conductance Ca2+-activatedK+ channels.";,Wang Y.-W., Ding J.-P., Xia X.-M., Lingle C.J.;,J. Neurosci. 22:1550-1561(2002).,PubMeb:11880485

• "Haem can bind to and inhibit mammalian calcium-dependent Slo1 BKchannels.";,Tang X.D., Xu R., Reynolds M.F., Garcia M.L., Heinemann S.H.,Hoshi T.;,Nature 425:531-535(2003).,PubMeb:14523450 DOI:10.1038/nature02003

• "Gating mechanism of BK (Slo1) channels: so near, yet so far.";,Magleby K.L.;,J. Gen. Physiol. 121:81-96(2003).,PubMeb:12566537

• "Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";,Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;,Cell 131:1190-1203(2007).,PubMeb:18083107 DOI:10.1016/j.cell.2007.11.025

• "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column.";,Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.;,Anal. Sci. 24:161-166(2008).,PubMeb:18187866 DOI:10.2116/analsci.24.161

• "LRRC26 auxiliary protein allows BK channel activation at restingvoltage without calcium.";,Yan J., Aldrich R.W.;,Nature 466:513-516(2010).,PubMeb:20613726 DOI:10.1038/nature09162

• "Characterizing the role of Thr352 in the inhibition of the largeconductance Ca2+-activated K+ channels by 1-[1-Hexyl-6-(methyloxy)-1H-indazol-3-yl]-2-methyl-1-propanone.";,Gordon E., Semus S.F., Lozinskaya I.M., Lin Z., Xu X.;,J. Pharmacol. Exp. Ther. 334:402-409(2010).,PubMeb:20430843 DOI:10.1124/jpet.110.166017

• "Calcium-sensitive potassium channelopathy in human epilepsy andparoxysmal movement disorder.";,Du W., Bautista J.F., Yang H., Diez-Sampedro A., You S.-A., Wang L.,Kotagal P., Lueders H.O., Shi J., Cui J., Richerson G.B., Wang Q.K.;,Nat. Genet. 37:733-738(2005).,PubMeb:15937479 DOI:10.1038/ng1585