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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
LMX1A_MOUSE, Mus musculus (house mouse) Lmx1a LIM/homeobox protein LMX1A Functions
wild_type
Starting from $1600,
4 weeks
Protein Domains
mutant
Quote

Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 LIM homeobox transcription factor 1-alpha;
Alternative name(s):
 LIM/homeobox protein 1.1
LIM/homeobox protein LMX1A
Protein IDs
(Accession numbers)
UniProtKB
 Q9JKU8
NCBI RefSeq

NP_387501.1, NM_033652.5.
Organism
Latin Name/
(Common Name)
Mus musculus (Mouse).
Taxonomic Identifier (NCBI)
 10090
Gene Names
 Lmx1a [GenPool]
GeneID

110648
Genome
Annotation (Ensembl)

ENSMUST00000028003, ENSMUSP00000028003; ENSMUSG00000026686

ENSMUST00000111377, ENSMUSP00000107008; ENSMUSG00000026686
Protein Sequence
 
SEQUENCE   382 AA;  42857 MW;  6C856843FEAC6706 CRC64;
MLDGLKMEEN FQSAIETSAS FSSLLGRAVS PKSVCEGCQR VISDRFLLRL NDSFWHEQCV
QCASCKEPLE TTCFYRDKKL YCKYHYEKLF AVKCGGCFEA IAPNEFVMRA QKSVYHLSCF
CCCVCERQLQ KGDEFVLKEG QLLCKGDYEK ERELLSLVSP AASDSGKSDD EESLCKSAHG
AGKGASEDGK DHKRPKRPRT ILTTQQRRAF KASFEVSSKP CRKVRETLAA ETGLSVRVVQ
VWFQNQRAKM KKLARRQQQQ QQDQQNTQRL TSAQTNGSGN AGMEGIMNPY TTLPTPQQLL
AIEQSVYNSD PFRQGLTPPQ MPGDHMHPYG AEPLFHDLDS DDTSLSNLGD CFLATSEAGP
LQSRVGNPID HLYSMQNSYF TS
General annotation
Function
 Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.
Cofactor
Subunit structure
Subcellular location

Nucleus (By similarity).
Tissue specificity
Induction
Domain
Post-translational modification

Involvement in disease

Note=Defects in Lmx1a are the cause of the spontaneous neurologic mutant mouse, called 'dreher' (dr) and results from a failure of the roof plate to develop.
References

  • "The mouse Dreher gene Lmx1a controls formation of the roof plate inthe vertebrate CNS.";,Millonig J.H., Millen K.J., Hatten M.E.;,Nature 403:764-769(2000)., PubMeb:10693804 DOI:10.1038/35001573

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR001356, Homeobox.

IPR017970, Homeobox_CS.

IPR009057, Homeodomain-like.

IPR012287, Homeodomain-rel.

IPR001781, Znf_LIM.
Gene3D

G3DSA:1.10.10.60, Homeodomain-rel; 1.

G3DSA:2.10.110.10, Znf_LIM; 2.
PANTHER
Pfam

PF00046, Homeobox; 1.

PF00412, LIM; 2.
PRINTS
SUPFAM

SSF46689, Homeodomain_like; 1.
PROSITE

PS00027, HOMEOBOX_1; 1.

PS50071, HOMEOBOX_2; 1.

PS00478, LIM_DOMAIN_1; 2.

PS50023, LIM_DOMAIN_2; 2.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Polypeptide chain 1 - 382 382 LIM homeobox transcription factor 1- /FTId=PRO_0000075827.
Domain 33 - 92 60 LIM zinc-binding 1.
Domain 92 - 154 63 LIM zinc-binding 2.
DNA-binding region 195 - 254 60 Homeobox.
Compositionally biased region 240 - 274 35 Gln-rich.
Compositionally biased region 257 - 265 9 Poly-Gln.
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

Q9JKU8
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG052335
InParanoid

Q9JKU8
OMA

AAEDGKD
OrthoDB

EOG4QFWDN
Proteomics
Database (PRIDE)

Q9JKU8
Comparative
Toxicogenomics
Database (CTD)

4009
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Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
Fax: 1-732-210-0262