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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
MPPE1_RAT, Rattus norvegicus (Norway rat) Mppe1 Post-GPI attachment to proteins factor 5 Functions
wild_type
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Protein Domains
mutant
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Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Metallophosphoesterase 1;
Alternative name(s):
 Post-GPI attachment to proteins factor 5
Protein IDs
(Accession numbers)
UniProtKB
 B1WC86
NCBI RefSeq

NP_001101905.1, NM_001108435.2.
Organism
Latin Name/
(Common Name)
Rattus norvegicus (Rat).
Taxonomic Identifier (NCBI)
 10116
Gene Names
 Mppe1 [GenPool]
GeneID

361344
Genome
Annotation (Ensembl)

ENSRNOT00000025164, ENSRNOP00000025164; ENSRNOG00000018648
Protein Sequence
 
SEQUENCE   394 AA;  45654 MW;  C2C8F762424CECE6 CRC64;
MALVRWGLRR QNFHLLRRRR VLLLKLTVVV ISVLLFCEYF IYYLVLFRCH WPEVKMPARG
GRQEPVLKAM FLADTHLLGE IRGHWLDKLR REWQMERAFQ TALWLLQPEV VFILGDVFDE
GKWSSAQAWA DDLHRFQRMF RHGSHVQLKV VIGNHDIGFH YQMSKYRINR FEKVFGSERL
FSLKGVNFVM VNSVAMEGDG CTICSEAEAE LREISRKLNC SQEQVQGSSQ CDHEPRLPLS
APVLLQHYPL YRASDANCSG EDAAPPEERS VPFEEKYDVL SREASQKLLW WLRPRLILSG
HTHSACEVLH PGGAPEVSVP SFSWRNRNNP SFIMGSLTSR DYALSKCYLP CEDTVLTTYC
AAAAFLLVLI LAHFERLPSS FLFGWKLCRS HLRR
General annotation
Function
 Metallophosphoesterase required for transport of GPI- anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins (By similarity).
Cofactor
 Binds 2 manganese ions per subunit (By similarity).
Subunit structure
 Interacts with GPI-anchor proteins. Interacts with TMED10 (By similarity).
Subcellular location

Golgi apparatus, cis-Golgi network membrane; Multi-pass membrane protein (By similarity). Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein (By similarity). Note=Also localizes to endoplasmic reticulum exit site (By similarity).
Tissue specificity
Induction
Domain
Post-translational modification

Involvement in disease

References

  • Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;,Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.

  • "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

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Protein Domain Databases
InterPro

IPR004843, Metallo-dependent_Pase_dom.
Gene3D
PANTHER
Pfam

PF00149, Metallophos; 1.
PRINTS
SUPFAM
PROSITE
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Polypeptide chain 1 - 394 394 Metallophosphoesterase 1. /FTId=PRO_0000355204.
Transmembrane region 27 - 47 21 Helical; (Potential).
Transmembrane region 354 - 374 21 Helical; (Potential).
Compositionally biased region 17 - 20 4 Poly-Arg.
Metal ion 74 1 Divalent metal cation 2 (By similarity).
Metal ion 116 1 Divalent metal cation 1 (By similarity).
Metal ion 116 1 Divalent metal cation 2 (By similarity).
Metal ion 154 1 Divalent metal cation 1 (By similarity).
Metal ion 247 1 Divalent metal cation 1 (By similarity).
Metal ion 301 1 Divalent metal cation 1 (By similarity).
Metal ion 303 1 Divalent metal cation 2 (By similarity).
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG101555
InParanoid
OMA

AVLLFCE
OrthoDB

EOG46Q6SX
Proteomics
Database (PRIDE)
Comparative
Toxicogenomics
Database (CTD)

65258
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