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Reviewed (UniProtKB/Swiss-Prot)

Note: Proteins listed in ProtBank™ database are NOT off-the-shelf [catalog] proteins. Customized protein production request can be made for any protein in this database by clicking on the corresponding button under "Quick Quote". Please ensure sequence accuracy and/or make any necessary modifications prior to submitting your quote request

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Reviewed (UniProtKB/Swiss-Prot)


Name Gene Symbol Rec Full Name Protein Information Quick Quote  Price,
Turnaround
MTR1A_HUMAN, Homo sapiens (human) MTNR1A Melatonin receptor type 1A Functions
wild_type
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Protein Domains
mutant
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Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Melatonin receptor type 1A;
Alternative name(s):
Protein IDs
(Accession numbers)
UniProtKB
 P48039
NCBI RefSeq

NP_005949.1, NM_005958.3.
Organism
Latin Name/
(Common Name)
Homo sapiens (Human).
Taxonomic Identifier (NCBI)
 9606
Gene Names
 MTNR1A [GenPool]
GeneID

4543
Genome
Annotation (Ensembl)

ENST00000307161, ENSP00000302811; ENSG00000168412
Protein Sequence
 
SEQUENCE   350 AA;  39375 MW;  DF7C67111D2386ED CRC64;
MQGNGSALPN ASQPVLRGDG ARPSWLASAL ACVLIFTIVV DILGNLLVIL SVYRNKKLRN
AGNIFVVSLA VADLVVAIYP YPLVLMSIFN NGWNLGYLHC QVSGFLMGLS VIGSIFNITG
IAINRYCYIC HSLKYDKLYS SKNSLCYVLL IWLLTLAAVL PNLRAGTLQY DPRIYSCTFA
QSVSSAYTIA VVVFHFLVPM IIVIFCYLRI WILVLQVRQR VKPDRKPKLK PQDFRNFVTM
FVVFVLFAIC WAPLNFIGLA VASDPASMVP RIPEWLFVAS YYMAYFNSCL NAIIYGLLNQ
NFRKEYRRII VSLCTARVFF VDSSNDVADR VKWKPSPLMT NNNVVKVDSV
General annotation
Function
 High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Cofactor
Subunit structure
Subcellular location

Cell membrane; Multi-pass membrane protein.
Tissue specificity
 Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "Cloning and characterization of a mammalian melatonin receptor thatmediates reproductive and circadian responses.";,Reppert S.M., Weaver D.R., Ebisawa T.;,Neuron 13:1177-1185(1994)., PubMeb:7946354 DOI:10.1016/0896-6273(94)90055-8

  • "Alleic variants of human melatonin 1a receptor: function andprevalence in subjects with circadian rhythm sleep disorders.";,Ebisawa T., Kajimura N., Uchiyama M., Katoh M., Sekimoto M.,Watanabe T., Ozeki Y., Ikeda M., Jodoi T., Sugishita M., Iwase T.,Kamei Y., Kim K., Shibui K., Kudo Y., Yamada N., Toyoshima R.,Okawa M., Takahashi K., Yamauchi T.;,Biochem. Biophys. Res. Commun. 262:832-837(1999)., PubMeb:10471411 DOI:10.1006/bbrc.1999.1308

  • Huang Y.-H., Kaighin V.A., Martin A.L., Aronstam R.S.;,Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.

  • "The status, quality, and expansion of the NIH full-length cDNAproject: the Mammalian Gene Collection (MGC).";,Genome Res. 14:2121-2127(2004).,PubMeb:15489334 DOI:10.1101/gr.2596504

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Protein Domain Databases | 3D Structure Database  | Sequence Annotation | Protein-protein Interaction Databases  | 
Binary Interactions | Enzyme and Pathway Databases |  Phylogenomic Database | Proteomics Database | 
Comparative Toxicogenomics Database | Order
Protein Domain Databases
InterPro

IPR000276, 7TM_GPCR_Rhodpsn.

IPR017452, GPCR_Rhodpsn_supfam.

IPR002278, Mel_1A_rcpt.

IPR000025, Melatonin_rcpt.
Gene3D
PANTHER
Pfam

PF00001, 7tm_1; 1.
PRINTS

PR00237, GPCRRHODOPSN.

PR01149, MELATONIN1AR.

PR00857, MELATONINR.
SUPFAM
PROSITE

PS00237, G_PROTEIN_RECEP_F1_1; 1.

PS50262, G_PROTEIN_RECEP_F1_2; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Polypeptide chain 1 - 350 350 Melatonin receptor type 1A. /FTId=PRO_0000069862.
Topological domain 1 - 29 29 Extracellular (Potential).
Topological domain 51 - 63 13 Cytoplasmic (Potential).
Topological domain 85 - 102 18 Extracellular (Potential).
Topological domain 124 - 142 19 Cytoplasmic (Potential).
Topological domain 164 - 187 24 Extracellular (Potential).
Topological domain 209 - 240 32 Cytoplasmic (Potential).
Topological domain 262 - 274 13 Extracellular (Potential).
Topological domain 296 - 350 55 Cytoplasmic (Potential).
Transmembrane region 30 - 50 21 Helical; Name=1; (Potential).
Transmembrane region 64 - 84 21 Helical; Name=2; (Potential).
Transmembrane region 103 - 123 21 Helical; Name=3; (Potential).
Transmembrane region 143 - 163 21 Helical; Name=4; (Potential).
Transmembrane region 188 - 208 21 Helical; Name=5; (Potential).
Transmembrane region 241 - 261 21 Helical; Name=6; (Potential).
Transmembrane region 275 - 295 21 Helical; Name=7; (Potential).
Glycosylation site 4 1 N-linked (GlcNAc...) (Potential).
Glycosylation site 10 1 N-linked (GlcNAc...) (Potential).
Disulfide bond 100 - 177 78 By similarity.
Natural variance 54 1 R -> W (exhibits significantly reduced /FTId=VAR_009260.
Natural variance 157 1 A -> V (similar binding characteristics /FTId=VAR_009261.
Natural variance 212 1 I -> T (in dbSNP:rs7654853). /FTId=VAR_049420.
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING

P48039
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome

REACT_14797, Signaling by GPCR.
Phylogenomic Database
HOVERGEN

HBG052528
InParanoid

P48039
OMA

EYRRIIV
OrthoDB
Proteomics
Database (PRIDE)

P48039
Comparative
Toxicogenomics
Database (CTD)

4543
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